F-15599
- Product Name
- F-15599
- CAS No.
- 635323-95-4
- Chemical Name
- F-15599
- Synonyms
- F15;F-15;F 15;NLX101;NLX 101;F-15599;NLX-101;NLX-101 ，S3510;NLX-101 F-15599;F-15599, 10 mM in DMSO
- CBNumber
- CB83175541
- Molecular Formula
- C19H21ClF2N4O
- Formula Weight
- 394.85
- MOL File
- 635323-95-4.mol
F-15599 Property
- Melting point:
- 195 °C
- Boiling point:
- 534.7±50.0 °C(Predicted)
- Density
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:200.0(Max Conc. mg/mL);506.5(Max Conc. mM)
- form
- Solid
- pka
- 8.20±0.20(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-6813
- Product name
- F-15599
- Purity
- 99.61%
- Packaging
- 1mg
- Price
- $1224
- Updated
- 2021/12/16
- Product number
- CS-6813
- Product name
- F-15599
- Purity
- 99.61%
- Packaging
- 5mg
- Price
- $2436
- Updated
- 2021/12/16
- Product number
- CS-6813
- Product name
- F-15599
- Purity
- 99.61%
- Packaging
- 10mg
- Price
- $4140
- Updated
- 2021/12/16
- Product number
- CS-6813
- Product name
- F-15599
- Purity
- 99.61%
- Packaging
- 20mg
- Price
- $7308
- Updated
- 2021/12/16
- Product number
- DC26175
- Product name
- NLX-101（F-15599）
- Packaging
- 100mg
- Price
- $500
- Updated
- 2021/12/16
F-15599 Chemical Properties,Usage,Production
Uses
F-15599 is a highly selective G-protein biased 5-HT1A receptor agonist, with Ki of 3.4 nM.
in vivo
F15599 (0.06 or 0.12 mg/kg) significantly reduces l-DOPA-induced dyskinesia (LID), without affecting motor performance of rats. Rats treated with F15599 manifest less LID and mild 5-HT syndrome with the high dose of 30 μg/μL[1]. F15599 (0.0625, 0.125, 0.25, 0.5 and 1.0 mg/kg, i,p,) results in a significant and dose-dependent (MED?=?0.125 mg/kg) delay in the latency to attack, and a potent reduction (ID50?=?0.095 mg/kg) in the amount of aggressive behaviour directed towards the intruder rat. Starting from the 0.25 mg/kg dose, F15599 induces clear signs of the so-called serotonin syndrome characterized by flat body posture, head-waving, lower lip retraction and hindlimb abduction, leading to increased behavioural inactivity scores and social disengagement[2]. F15599 increases the discharge rate of pyramidal neurones in medial prefrontal cortex (mPFC) from 0.2 μg/kg i.v and reduces that of dorsal raphe 5-hydroxytryptaminergic neurones at doses >10-fold higher (minimal effective dose 8.2 μg/kg i.v.). F15599 increases dopamine output in mPFC (an effect dependent on the activation of postsynaptic 5-HT1A receptors) with an ED50 of 30 μg/kg i.p., whereas it reduces hippocampal 5-HT release (an effect dependent exclusively on 5-HT1A autoreceptor activation) with an ED50 of 240 μg/kg i.p[3].
IC 50
5-HT1A Receptor: 3.4 nM (Ki)
References
[1] Meadows SM, et al. Characterizing the differential roles of striatal 5-HT1A auto- and hetero-receptors in the reduction of l-DOPA-induced dyskinesia. Exp Neurol. 2017 Jun;292:168-178. DOI:10.1016/j.expneurol.2017.03.013
[2] de Boer SF, et al. Anti-aggressive effects of the selective high-efficacy 'biased' 5-HT?A receptor agonists F15599 and F13714 in male WTG rats. Psychopharmacology (Berl). 2016 Mar;233(6):937-47. DOI:10.1007/s00213-015-4173-x
[3] Lladó-Pelfort L, et al. Preferential in vivo action of F15599, a novel 5-HT(1A) receptor agonist, at postsynaptic 5-HT(1A) receptors. Br J Pharmacol. 2010 Aug;160(8):1929-40. DOI:10.1111/j.1476-5381.2010.00738.x
F-15599 Preparation Products And Raw materials
Raw materials
Preparation Products
F-15599 Suppliers
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- +1-708-310-1919 +1-13798911105
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- 708-557-7486
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- United States
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- Country
- United States
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