BCX-4161

Product Name: BCX-4161
CAS No.: 918407-35-9
Chemical Name: BCX-4161
Synonyms: BCX-4161;Avoralstat;Avoralstat(BCX-4161);Avoralstat Impurity 1;Avoralstat, 10 mM in DMSO;BCX-4161; BCX 4161; BCX4161; AVORALSTAT;3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinic acid;2-Pyridinecarboxylic acid, 3-[2-[[[4-(aminoiminomethyl)phenyl]amino]carbonyl]-4-ethenyl-5-methoxyphenyl]-6-[[(cyclopropylmethyl)amino]carbonyl]-;Serine proteases,Avoralstat,BCX 4161,hereditary,bradykinin,Threonine proteases,angioedema,Inhibitor,Serine endopeptidases,BCX-4161,inhibit,Ser/Thr Protease,oral
CBNumber: CB83312863
Molecular Formula: C28H27N5O5
Formula Weight: 513.54
MOL File: 918407-35-9.mol

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BCX-4161 Property

Density: 1.38±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO:50.0(Max Conc. mg/mL);97.36(Max Conc. mM)
form: A solid
pka: 2.99±0.36(Predicted)
color: White to yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Alichem

Product number: 918407359
Product name: 3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinicacid
Packaging: 25mg
Price: $609.56
Updated: 2021/12/16

Alichem

Product number: 918407359
Product name: 3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinicacid
Packaging: 100mg
Price: $1617.2
Updated: 2021/12/16

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BCX-4161 Chemical Properties,Usage,Production

Uses

Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2].

References

[1] Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5. DOI:10.1016/j.jaci.2016.03.043
[2] Cornpropst M, et al. Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study. Allergy. 2016;71(12):1676-1683. DOI:10.1111/all.12930

BCX-4161 Preparation Products And Raw materials

Raw materials

Preparation Products

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BCX-4161 Suppliers

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918407-35-9, BCX-4161Related Search:

Avoralstat

BCX-4161

Avoralstat(BCX-4161)

BCX-4161; BCX 4161; BCX4161; AVORALSTAT

2-Pyridinecarboxylic acid, 3-[2-[[[4-(aminoiminomethyl)phenyl]amino]carbonyl]-4-ethenyl-5-methoxyphenyl]-6-[[(cyclopropylmethyl)amino]carbonyl]-

Serine proteases,Avoralstat,BCX 4161,hereditary,bradykinin,Threonine proteases,angioedema,Inhibitor,Serine endopeptidases,BCX-4161,inhibit,Ser/Thr Protease,oral

3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinic acid

Avoralstat Impurity 1

Avoralstat, 10 mM in DMSO

918407-35-9