BCX-4161
- Product Name
- BCX-4161
- CAS No.
- 918407-35-9
- Chemical Name
- BCX-4161
- Synonyms
- BCX-4161;Avoralstat;Avoralstat(BCX-4161);Avoralstat Impurity 1;Avoralstat, 10 mM in DMSO;BCX-4161; BCX 4161; BCX4161; AVORALSTAT;3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinic acid;2-Pyridinecarboxylic acid, 3-[2-[[[4-(aminoiminomethyl)phenyl]amino]carbonyl]-4-ethenyl-5-methoxyphenyl]-6-[[(cyclopropylmethyl)amino]carbonyl]-;Serine proteases,Avoralstat,BCX 4161,hereditary,bradykinin,Threonine proteases,angioedema,Inhibitor,Serine endopeptidases,BCX-4161,inhibit,Ser/Thr Protease,oral
- CBNumber
- CB83312863
- Molecular Formula
- C28H27N5O5
- Formula Weight
- 513.54
- MOL File
- 918407-35-9.mol
BCX-4161 Property
- Density
- 1.38±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:50.0(Max Conc. mg/mL);97.36(Max Conc. mM)
- form
- A solid
- pka
- 2.99±0.36(Predicted)
- color
- White to yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 918407359
- Product name
- 3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinicacid
- Packaging
- 25mg
- Price
- $609.56
- Updated
- 2021/12/16
- Product number
- 918407359
- Product name
- 3-(2-((4-Carbamimidoylphenyl)carbamoyl)-5-methoxy-4-vinylphenyl)-6-((cyclopropylmethyl)carbamoyl)picolinicacid
- Packaging
- 100mg
- Price
- $1617.2
- Updated
- 2021/12/16
BCX-4161 Chemical Properties,Usage,Production
Uses
Avoralstat (BCX4161), a potent and orally active plasma kallikrein (PKK) inhibitor, is used for hereditary angioedema research[1][2].
References
[1] Aygoren-Pursun E, et al. Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat. J Allergy Clin Immunol. 2016 Sep;138(3):934-936.e5. DOI:10.1016/j.jaci.2016.03.043
[2] Cornpropst M, et al. Safety, pharmacokinetics, and pharmacodynamics of avoralstat, an oral plasma kallikrein inhibitor: phase 1 study. Allergy. 2016;71(12):1676-1683. DOI:10.1111/all.12930
BCX-4161 Preparation Products And Raw materials
Raw materials
Preparation Products
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