H-TYR-GLY-PHE-GLY-GLY-OH

Product Name: H-TYR-GLY-PHE-GLY-GLY-OH
CAS No.: 105250-85-9
Chemical Name: H-TYR-GLY-PHE-GLY-GLY-OH
Synonyms: historphin;OGP (10-14);Tyr-Gly-Phe-Gly-gly;H-TYR-GLY-PHE-GLY-GLY-OH;osteogénico (OGP10-14, YGFGG);OSTEOGENIC GROWTH PEPTIDE (10-14);Tyrosyl-glycyl-phenylalanyl-glycyl-glycine;Osteogenic Growth Peptide (10-14)、OGP(10-14);Glycine, L-tyrosylglycyl-L-phenylalanylglycyl-;Glycine, N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl)-
CBNumber: CB8376455
Molecular Formula: C24H29N5O7
Formula Weight: 499.52
MOL File: 105250-85-9.mol

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H-TYR-GLY-PHE-GLY-GLY-OH Property

Boiling point:: 1028.0±65.0 °C(Predicted)
Density: 1.352±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 3.32±0.10(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0027162
Product name: OsteogenicGrowthPeptide10-14
Packaging: 1mg
Price: $250
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: PEP0010255
Product name: TYR-GLY-PHE-GLY-GLY-OH
Purity: 95.00%
Packaging: 5MG
Price: $501.49
Updated: 2021/12/16

ChemScene

Product number: CS-0027162
Product name: OsteogenicGrowthPeptide10-14
Packaging: 5mg
Price: $630
Updated: 2021/12/16

ChemScene

Product number: CS-0027162
Product name: OsteogenicGrowthPeptide10-14
Packaging: 10mg
Price: $1050
Updated: 2021/12/16

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H-TYR-GLY-PHE-GLY-GLY-OH Chemical Properties,Usage,Production

Uses

Osteogenic Growth Peptide (10-14) (OGP(10-14)), the C-terminal truncated pentapeptide of osteogenic growth peptide (OGP), retains the full OGP-like activity. Osteogenic Growth Peptide (10-14) is responsible for the binding to the OGP receptor and activates an intracellular Gi-protein-MAP kinase signaling pathway. Osteogenic Growth Peptide (10-14) is a potent mitogen and stimulator of osteogenesis and hematopoiesis. Osteogenic Growth Peptide (10-14) acts as a Src inhibitor[1][2][3][4].

in vivo

Osteogenic Growth Peptide (10-14) (OGP(10-14)) increases bone formation and trabecular bone density and stimulates fracture healing when administered to mice and rats^[1].

References

[1] Chen YC, et al. Bioactive pseudopeptidic analogues and cyclostereoisomers of osteogenic growth peptide C-terminal pentapeptide, OGP(10-14). J Med Chem. 2002;45(8):1624-1632. DOI:10.1021/jm010479l
[2] Chen Z, et al. Regulation of endochondral ossification by osteogenic growth peptide C-terminal pentapeptide [OGP(10-14)]. Protein Pept Lett. 2009;16(9):1074-1080. DOI:10.2174/092986609789055395
[3] Fazzi R, et al. Bone and bone-marrow interactions: haematological activity of osteoblastic growth peptide (OGP)-derived carboxy-terminal pentapeptide. Mobilizing properties on white blood cells and peripheral blood stem cells in mice. Leuk Res. 2002;26(1) DOI:10.1016/s0145-2126(01)00091-1
[4] Battolla B, et al. The small peptide OGP(10-14) reduces proliferation and induces differentiation of TPO-primed M07-e cells through RhoA/TGFbeta1/SFK pathway. Med Sci Monit. 2011;17(1):SC1-SC5. DOI:10.12659/msm.881309

H-TYR-GLY-PHE-GLY-GLY-OH Preparation Products And Raw materials

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Preparation Products

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H-TYR-GLY-PHE-GLY-GLY-OH Suppliers

China 42 United States 5 Global 47

GL Biochem (Shanghai) Ltd

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Nanjing Peptide Biotech Ltd.

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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105250-85-9, H-TYR-GLY-PHE-GLY-GLY-OHRelated Search:

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OSTEOGENIC GROWTH PEPTIDE (10-14)

OGP (10-14)

H-TYR-GLY-PHE-GLY-GLY-OH

historphin

Glycine, N-(N-(N-(N-L-tyrosylglycyl)-L-phenylalanyl)glycyl)-

Tyr-Gly-Phe-Gly-gly

Tyrosyl-glycyl-phenylalanyl-glycyl-glycine

Glycine, L-tyrosylglycyl-L-phenylalanylglycyl-

osteogénico (OGP10-14, YGFGG)

Osteogenic Growth Peptide (10-14)、OGP(10-14)

105250-85-9