ChemicalBook > CAS DataBase List > 2-Chloro-6-fluorobenzothiazole

2-Chloro-6-fluorobenzothiazole

Product Name
2-Chloro-6-fluorobenzothiazole
CAS No.
399-74-6
Chemical Name
2-Chloro-6-fluorobenzothiazole
Synonyms
IFLAB-BB F1910-0016;2-CHLORO-6-FLUOROBENZOTHIAZOLE;2-CHLORO-6-FLUOROBENZO[D]THIAZOLE;Benzothiazole, 2-chloro-6-fluoro-;2-CHLORO-6-FLUORO-1,3-BENZOTHIAZOLE;Benzothiazole, 2-chloro-6-fluoro- (8CI,9CI);JR-8570, 2-Chloro-6-fluorobenzo[d]thiazole, 97%
CBNumber
CB8380946
Molecular Formula
C7H3ClFNS
Formula Weight
187.62
MOL File
399-74-6.mol
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2-Chloro-6-fluorobenzothiazole Property

Melting point:
91-95 °C
Boiling point:
253.0±13.0 °C(Predicted)
Density 
1.532±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
powder to crystal
pka
-0.39±0.10(Predicted)
color 
White to Light yellow
CAS DataBase Reference
399-74-6(CAS DataBase Reference)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
HS Code 
29342000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
667358
Product name
2-Chloro-6-fluorobenzothiazole
Purity
97%
Packaging
1g
Price
$57.4
Updated
2023/06/20
Sigma-Aldrich
Product number
667358
Product name
2-Chloro-6-fluorobenzothiazole
Purity
97%
Packaging
5g
Price
$245
Updated
2023/06/20
TCI Chemical
Product number
C2607
Product name
2-Chloro-6-fluorobenzothiazole
Purity
>98.0%(GC)
Packaging
1g
Price
$100
Updated
2025/07/31
TCI Chemical
Product number
C2607
Product name
2-Chloro-6-fluorobenzothiazole
Purity
>98.0%(GC)
Packaging
5g
Price
$396
Updated
2025/07/31
TRC
Product number
C584905
Product name
2-Chloro-6-fluorobenzo[d]thiazole
Packaging
500mg
Price
$65
Updated
2021/12/16
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2-Chloro-6-fluorobenzothiazole Chemical Properties,Usage,Production

Chemical Properties

White solid

Biological Activity

2-Chloro-6-fluorobenzothiazole is a potent inhibitor of diacylglycerol acyltransferase, an enzyme involved in the biosynthesis of triglycerides. It has been shown to inhibit the enzymatic activity of this enzyme and decrease triglyceride levels by inhibiting the production of fatty acids.

Synthesis

348-40-3

399-74-6

General procedure for the synthesis of 2-chloro-6-fluorobenzothiazole from 2-amino-6-fluorobenzothiazole: In a round-bottomed flask, 2-amino-6-fluorobenzothiazole (1.0017 g, 5.96 mmol, Sigma-Aldrich Chemical Company, Inc.), copper(II) chloride (1.201 g, 8.93 mmol, Sigma-Aldrich Chemical Company, Inc.) and tert-butyl nitrite (1.063 mL, 8.93 mmol, Acros Organics) in acetonitrile (ACN). The reaction mixture was heated to 65 °C and kept at this temperature for 2 hours. After completion of the reaction, the reaction mixture was diluted with 1N hydrochloric acid and extracted with ethyl acetate (EtOAc). The organic phase was washed sequentially with water and saturated sodium chloride solution, dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure to afford the target product 2-chloro-6-fluorobenzothiazole (0.9249 g, 4.93 mmol, 83% yield). The structure of the product was confirmed by 1H NMR (400 MHz, DMSO-d6): δ 7.45 (td, J = 9.10, 2.74 Hz, 1H), 7.97-8.07 (m, 2H).

References

[1] Patent: US2013/225552, 2013, A1. Location in patent: Paragraph 0976
[2] Patent: WO2012/69503, 2012, A1. Location in patent: Page/Page column 18-19
[3] Patent: US2013/172326, 2013, A1. Location in patent: Paragraph 0081; 0082
[4] Journal of the Indian Chemical Society, 1933, vol. 10, p. 465,469
[5] Farmaco, Edizione Scientifica, 1977, vol. 32, p. 348 - 354

2-Chloro-6-fluorobenzothiazole Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-6-fluorobenzothiazole manufacturers

Honest Joy Holdings Limited
Product
2-Chloro-6-fluorobenzo[d]thiazole 399-74-6
Price
US $0.00/KG
Min. Order
1KG
Purity
99.4%
Supply Ability
100 tons
Release date
2022-01-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
2-Chloro-6-fluorobenzothiazole 399-74-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-11
Career Henan Chemical Co
Product
2-Chloro-6-fluorobenzothiazole 399-74-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-24

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