5-(3-Chlorophenyl)-3-hydroxypicolinic acid
- Product Name
- 5-(3-Chlorophenyl)-3-hydroxypicolinic acid
- CAS No.
- 1415226-40-2
- Chemical Name
- 5-(3-Chlorophenyl)-3-hydroxypicolinic acid
- Synonyms
- 5-(3-Chlorophenyl)-3-hydroxypicolinic acid;5-(3-Chlorophenyl)-3-hydroxy-2-pyridinecarboxylic acid;5-(3-chlorophenyl)-3-hydroxypyridine-2-carboxylic acid;2-Pyridinecarboxylic acid, 5-(3-chlorophenyl)-3-hydroxy-
- CBNumber
- CB84196589
- Molecular Formula
- C12H8ClNO3
- Formula Weight
- 249.65
- MOL File
- 1415226-40-2.mol
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Property
- Boiling point:
- 543.3±50.0 °C(Predicted)
- Density
- 1.461±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 1.01±0.50(Predicted)
- InChI
- InChI=1S/C12H8ClNO3/c13-9-3-1-2-7(4-9)8-5-10(15)11(12(16)17)14-6-8/h1-6,15H,(H,16,17)
- InChIKey
- KMZAXKDGIXGPOF-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)=NC=C(C2=CC=CC(Cl)=C2)C=C1O
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 3368DT
- Product name
- 5-(3-Chlorophenyl)-3-hydroxypyridine-2-carboxylicacid
- Packaging
- 10g
- Price
- $1518
- Updated
- 2021/12/16
- Product number
- CM249306
- Product name
- 5-(3-Chlorophenyl)-3-hydroxypicolinicacid
- Purity
- 97%
- Packaging
- 10g
- Price
- $1636
- Updated
- 2021/12/16
- Product number
- A261647
- Product name
- 5-(3-Chlorophenyl)-3-hydroxypicolinicacid
- Purity
- 97%
- Packaging
- 100mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- A261647
- Product name
- 5-(3-Chlorophenyl)-3-hydroxypicolinicacid
- Purity
- 97%
- Packaging
- 250mg
- Price
- $134
- Updated
- 2021/12/16
- Product number
- A261647
- Product name
- 5-(3-Chlorophenyl)-3-hydroxypicolinicacid
- Purity
- 97%
- Packaging
- 1g
- Price
- $261
- Updated
- 2021/12/16
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Chemical Properties,Usage,Production
Uses
5-(3-Chlorophenyl)-3-hydroxy-2-pyridinecarboxylic Acid can be used for hydroxylase enzyme inhibitors.
Synthesis
1415226-39-9
1415226-40-2
The general procedure for the synthesis of 5-(3-chlorophenyl)-3-methoxypicolinonitrile as a raw material for 5-(3-chlorophenyl)-3-hydroxypyridine carboxylic acid was as follows: to a 20 L reactor equipped with a mechanical stirrer, condenser tube, thermometer and nitrogen inlet was added 5-(3-chlorophenyl)-3-methoxy-2-cyano-pyridine (440.6 g, 1.8 mol) and 37% hydrochloric acid aqueous solution (5302g). The reaction mixture was heated to 102 °C under stirring and maintained for 24 hours. Subsequently, 37% aqueous hydrochloric acid solution (2653 g) was added and stirring was continued at 104 °C for 18 hours. After completion of the reaction, the mixture was cooled to 5 °C, water (4410 g) was added and stirred at 0 °C for 16 hours. The precipitated product was separated by filtration and washed with water until the filtrate had a pH of 6 (about 8000 L of water was consumed). The filter cake was dried under reduced pressure for 2 hours. Afterwards, the filter cake was retransferred to a reactor and ground with THF (1958 g, 2201 mL) for 2 hours at room temperature. The solid product was again separated by filtration and washed with THF (778 g, 875 mL), and finally dried under reduced pressure for 48 h at 5 °C to give an off-white solid product of 385 g (89% yield). HPLC analysis showed the product purity to be 96.2%.1H NMR (DMSO-d6) data were as follows: δ 8.52 (d, 1H), 7.99 (d, 1H) 7.95 (s, 1H), 7.81 (t, 1H), 7.57 (s, 1H), 7.55 (s, 1H).
References
[1] Patent: US2012/309977, 2012, A1. Location in patent: Page/Page column 20-21
[2] Patent: WO2016/153996, 2016, A1. Location in patent: Paragraph 00130
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Preparation Products And Raw materials
Raw materials
Preparation Products
5-(3-Chlorophenyl)-3-hydroxypicolinic acid Suppliers
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- Country
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View Lastest Price from 5-(3-Chlorophenyl)-3-hydroxypicolinic acid manufacturers
- Product
- 5-(3-chlorophenyl)-3-hydroxypicolinic acid
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 1
- Release date
- 2025-08-22