N-DESMETHYL ROSIGLITAZONE

Product Name: N-DESMETHYL ROSIGLITAZONE
CAS No.: 257892-31-2
Chemical Name: N-DESMETHYL ROSIGLITAZONE
Synonyms: SB 237216;N-DESMETHYL ROSIGLITAZONE;N-Desmethyl Rosiglitazone Solution, 100ppm;5-[[4-[2-(2-pyridinylamino]ethoxy]phenyl]methyl]-2,4-thiazolidinedione;2,4-Thiazolidinedione, 5-[[4-[2-(2-pyridinylamino)ethoxy]phenyl]methyl]-;N-Desmethyl RosiglitazoneQ: What is N-Desmethyl Rosiglitazone Q: What is the CAS Number of N-Desmethyl Rosiglitazone Q: What is the storage condition of N-Desmethyl Rosiglitazone Q: What are the applications of N-Desmethyl Rosiglitazone
CBNumber: CB8433330
Molecular Formula: C17H17N3O3S
Formula Weight: 343.4
MOL File: 257892-31-2.mol

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N-DESMETHYL ROSIGLITAZONE Property

Melting point:: 177-179°C
storage temp.: -20°C Freezer
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
color: Off-White to Pale Beige

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22103
Product name: N-desmethyl Rosiglitazone
Purity: ≥98%
Packaging: 1mg
Price: $104
Updated: 2024/03/01

Cayman Chemical

Product number: 22103
Product name: N-desmethyl Rosiglitazone
Purity: ≥98%
Packaging: 5mg
Price: $395
Updated: 2024/03/01

Cayman Chemical

Product number: 22103
Product name: N-desmethyl Rosiglitazone
Purity: ≥98%
Packaging: 10mg
Price: $656
Updated: 2024/03/01

Usbiological

Product number: D3218-50
Product name: N-Desmethyl Rosiglitazone |
Packaging: 1mg
Price: $460
Updated: 2021/12/16

TRC

Product number: D292165
Product name: N-DesmethylRosiglitazone
Packaging: 2.5mg
Price: $155
Updated: 2021/12/16

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N-DESMETHYL ROSIGLITAZONE Chemical Properties,Usage,Production

Description

N-desmethyl Rosiglitazone is a major metabolite of rosiglitazone (Item Nos. 71740 | 71742 | 11884), a potent and selective PPARγ ligand present in formulations that have been used to treat type 2 diabetes. Rosiglitazone is metabolized by the cytochrome P450 (CYP) isoform CYP2C8 to form N-desmethyl rosiglitazone.

Chemical Properties

White Solid

Uses

A metabolite of Rosiglitazone.

Definition

ChEBI: N-desmethylrosiglitazone is an aromatic ether.

References

[1] J M LEHMANN. An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma).[J]. The Journal of Biological Chemistry, 1995, 270 22: 12953-12956. DOI: 10.1074/jbc.270.22.12953
[2] KWON-BOK KIM . Simultaneous quantification of rosiglitazone and its two major metabolites, N-desmethyl and p-hydroxy rosiglitazone in human plasma by liquid chromatography/tandem mass spectrometry: Application to a pharmacokinetic study[J]. Journal of Chromatography B, 2009, 877 20: Pages 1951-1956. DOI: 10.1016/j.jchromb.2009.05.001

N-DESMETHYL ROSIGLITAZONE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-DESMETHYL ROSIGLITAZONE Suppliers

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257892-31-2, N-DESMETHYL ROSIGLITAZONERelated Search:

5-(4-Fluorobenzyl)-2,4-thiazolidinedione 5-Hydroxy rosiglitazone-d4 5-[[4-[1,1,2,2-tetradeuterio-2-[(5-hydroxypyridin-2-yl)-methylamino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione Rosiglitazone maleate 5-[4-[N-(2-Pyridylamino)ethoxy]benzylidene]thiazolidine-2,4-dione 5-[[4-[2-[pyridin-2-yl(trideuteriomethyl)amino]ethoxy]phenyl]methyl]-1,3-thiazolidine-2,4-dione 5-HYDROXY ROSIGLITAZONE Rosiglitazone 5-(4-(2-(Methyl(pyridin-2-yl)amino)ethoxy)benzyl)thiazolidine-2,4-dione sodium salt 2,4-Thiazolidinedione DESMETHYL ROSIGLITAZONE-D4 AKOS 92116 ROSIGLITAZONE-5-SULFOXY ROSIGLITAZONE D-TARTRATE N-DESMETHYL ROSIGLITAZONE

SB 237216

N-Desmethyl Rosiglitazone Solution, 100ppm

N-DESMETHYL ROSIGLITAZONE

5-[[4-[2-(2-pyridinylamino]ethoxy]phenyl]methyl]-2,4-thiazolidinedione

2,4-Thiazolidinedione, 5-[[4-[2-(2-pyridinylamino)ethoxy]phenyl]methyl]-

N-Desmethyl RosiglitazoneQ: What is N-Desmethyl Rosiglitazone Q: What is the CAS Number of N-Desmethyl Rosiglitazone Q: What is the storage condition of N-Desmethyl Rosiglitazone Q: What are the applications of N-Desmethyl Rosiglitazone

257892-31-2

Various Metabolites and Impurities

Intermediates & Fine Chemicals

Metabolites & Impurities

Pharmaceuticals

Aromatics

Heterocycles

Sulfur & Selenium Compounds