ChemicalBook > CAS DataBase List > ECHINULIN

ECHINULIN

Product Name: ECHINULIN
CAS No.: 1859-87-6
Chemical Name: ECHINULIN
Synonyms: ECHINULIN;echinuline;2-(1,1-Dimethyl-2-propenyl)-5,7-diisopentenylcyclo(L-Trp-L-Ala-);(3S,6S)-3-[[2-(1,1-dimethylallyl)-5,7-bis(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]-6-methyl-piperazine-2,5-quinone;(3S,6S)-3-methyl-6-[[2-(2-methylbut-3-en-2-yl)-5,7-bis(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]piperazine-2,5-dione;(3S,6S)-3-[[2-(1,1-Dimethyl-2-propenyl)-5,7-bis(3-methyl-2-butenyl)-1H-indol-3-yl]methyl]-6-methyl-2,5-piperazinedione;2,5-Piperazinedione,3-[[2-(1,1-dimethyl-2-propen-1-yl)-5,7-bis(3-methyl-2-buten-1-yl)-1H-indol-3-yl]methyl]-6-methyl-,(3S,6S)-
CBNumber: CB8444608
Molecular Formula: C29H39N3O2
Formula Weight: 461.64
MOL File: 1859-87-6.mol

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ECHINULIN Property

Melting point:: 242-243°
alpha: D20 -26.0° (chloroform)
Boiling point:: 695.3±55.0 °C(Predicted)
Density: 1.068±0.06 g/cm3(Predicted)
solubility: Methanol: soluble
form: A solid
pka: 13.05±0.60(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P403+P233Store in a well-ventilated place. Keep container tightly closed.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 22711
Product name: Echinulin
Purity: ≥95%
Packaging: 1mg
Price: $242
Updated: 2024/03/01

Cayman Chemical

Product number: 22711
Product name: Echinulin
Purity: ≥95%
Packaging: 5mg
Price: $906
Updated: 2024/03/01

TRC

Product number: E325595
Product name: Echinulin
Packaging: 1mg
Price: $200
Updated: 2021/12/16

AK Scientific

Product number: W1039
Product name: Echinulin
Packaging: 1mg
Price: $368
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: MTB0000888
Product name: ECHINULIN
Purity: 95.00%
Packaging: 5MG
Price: $502.45
Updated: 2021/12/16

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ECHINULIN Chemical Properties,Usage,Production

Description

Echinulin is a diketopiperazine metabolite found in fungi that, when administered to rabbits, at a dose of 10 mg/kg, leads to liver and lung damage. It has no activity at the δ, κ, or μ-opioid receptors or the cannabinoid CB₁ and CB₂ receptors.

Uses

Echinulin is a metabolite of diketopiperazine.

Definition

ChEBI: Echinulin is an indole alkaloid with formula C29H39N3O2. It is a fungal metabolite found in several Aspergillus species. It has a role as an Aspergillus metabolite, a marine metabolite and a plant metabolite. It is a member of indoles, a member of 2,5-diketopiperazines, an olefinic compound and an indole alkaloid.

IC 50

NF-κB

References

[1] MUSLIM ALI . Toxicity of echinulin from Aspergillus chevalieri in rabbits[J]. Toxicology letters, 1989, 48 3: Pages 235-241. DOI: 10.1016/0378-4274(89)90049-0
[2] JIANGTAO GAO. Benzyl Derivatives with in Vitro Binding Affinity for Human Opioid and Cannabinoid Receptors from the Fungus Eurotium repens[J]. Journal of Natural Products , 2011, 74 7: 1636-1639. DOI: 10.1021/np200147c

ECHINULIN Preparation Products And Raw materials

Raw materials

Preparation Products

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1859-87-6, ECHINULINRelated Search:

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ECHINULIN

echinuline

(3S,6S)-3-[[2-(1,1-Dimethyl-2-propenyl)-5,7-bis(3-methyl-2-butenyl)-1H-indol-3-yl]methyl]-6-methyl-2,5-piperazinedione

2-(1,1-Dimethyl-2-propenyl)-5,7-diisopentenylcyclo(L-Trp-L-Ala-)

(3S,6S)-3-[[2-(1,1-dimethylallyl)-5,7-bis(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]-6-methyl-piperazine-2,5-quinone

(3S,6S)-3-methyl-6-[[2-(2-methylbut-3-en-2-yl)-5,7-bis(3-methylbut-2-enyl)-1H-indol-3-yl]methyl]piperazine-2,5-dione

2,5-Piperazinedione,3-[[2-(1,1-dimethyl-2-propen-1-yl)-5,7-bis(3-methyl-2-buten-1-yl)-1H-indol-3-yl]methyl]-6-methyl-,(3S,6S)-

1859-87-6

C29H39N3O2