ChemicalBook > CAS DataBase List > Danicopan

Danicopan

Product Name
Danicopan
CAS No.
1903768-17-1
Chemical Name
Danicopan
Synonyms
ACH-4471;Danicopan;ACH-0144471;Danicopan（ACH-4471）;Danicopan (ACH-4471) ，S0803;ACH4471,Complement System,ACH 4471,Danicopan,inhibit,Inhibitor;(2S,4R)-1-(2-(3-Acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide;2-Pyrrolidinecarboxamide, 1-[2-[3-acetyl-5-(2-methyl-5-pyrimidinyl)-1H-indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoro-, (2S,4R)-
CBNumber
CB84667810
Molecular Formula
C26H23BrFN7O3
Formula Weight
580.41
MOL File
1903768-17-1.mol
More
Less

Danicopan Property

Boiling point:
841.7±65.0 °C(Predicted)
Density 
1.61±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:175.0(Max Conc. mg/mL);301.51(Max Conc. mM)
form 
A solid
pka
11.48±0.40(Predicted)
color 
White to off-white
InChIKey
PIBARDGJJAGJAJ-NQIIRXRSSA-N
SMILES
N1(C(CN2C3=C(C=C(C4=CN=C(C)N=C4)C=C3)C(C(C)=O)=N2)=O)C[C@H](F)C[C@H]1C(NC1=NC(Br)=CC=C1)=O
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0068562
Product name
Danicopan
Purity
99.91%
Packaging
5mg
Price
$330
Updated
2021/12/16
ChemScene
Product number
CS-0068562
Product name
Danicopan
Purity
99.91%
Packaging
25mg
Price
$860
Updated
2021/12/16
DC Chemicals
Product number
DC11082
Product name
Danicopan(ACH-4471)
Purity
>98%
Packaging
100mg
Price
$950
Updated
2021/12/16
DC Chemicals
Product number
DC11082
Product name
Danicopan(ACH-4471)
Purity
>98%
Packaging
250mg
Price
$1500
Updated
2021/12/16
More
Less

Danicopan Chemical Properties,Usage,Production

Uses

Danicopan (ACH-4471), a selective and orally active small-molecule factor D inhibitor, shows high binding affinity to human Factor D with Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits alternative pathway of complement (APC) activity, has potential to block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS)[1].

References

[1] Yuan X, et al. Small-molecule factor D inhibitors selectively block the alternative pathway of complement in paroxysmal nocturnal hemoglobinuria and atypical hemolytic uremic syndrome. Haematologica. 2017 Mar;102(3):466-475. DOI:10.3324/haematol.2016.153312
[2] Boyer DD, Ko YP, Podos SD, et al. Danicopan, an Oral Complement Factor D Inhibitor, Exhibits High and Sustained Exposure in Ocular Tissues in Preclinical Studies. Transl Vis Sci Technol. 2022;11(10):37. DOI:10.1167/tvst.11.10.37

Danicopan Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Danicopan Suppliers

China 80 India 2 United States 5 Global 87
More
Less

View Lastest Price from Danicopan manufacturers

Shanghai Joiny Pharmaceutical Co.,LTD
Product
Danicopan 1903768-17-1
Price
US $0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1000kg
Release date
2025-11-12

1903768-17-1, DanicopanRelated Search:


  • ACH-0144471
  • Danicopan
  • ACH-4471
  • Danicopan（ACH-4471）
  • 2-Pyrrolidinecarboxamide, 1-[2-[3-acetyl-5-(2-methyl-5-pyrimidinyl)-1H-indazol-1-yl]acetyl]-N-(6-bromo-2-pyridinyl)-4-fluoro-, (2S,4R)-
  • (2S,4R)-1-(2-(3-Acetyl-5-(2-methylpyrimidin-5-yl)-1H-indazol-1-yl)acetyl)-N-(6-bromopyridin-2-yl)-4-fluoropyrrolidine-2-carboxamide
  • ACH4471,Complement System,ACH 4471,Danicopan,inhibit,Inhibitor
  • Danicopan (ACH-4471) ，S0803
  • 1903768-17-1
  • C26H23BrFN7O3