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TMI 1

Product Name
TMI 1
CAS No.
287403-39-8
Chemical Name
TMI 1
Synonyms
TMI 1;TMI 1,TMI1;TMI-1 >=98% (HPLC);(S)-4-((4-(But-2-yn-1-yloxy)phenyl)sulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide;(3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide;3-Thiomorpholinecarboxamide, 4-[[4-(2-butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-, (3S)-
CBNumber
CB84727413
Molecular Formula
C17H22N2O5S2
Formula Weight
398.5
MOL File
287403-39-8.mol
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TMI 1 Property

Density 
1.325±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
DMSO: 25 mg/ml
form 
powder
pka
9.25±0.23(Predicted)
color 
white to beige
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
PZ0336
Product name
TMI-1
Purity
≥98% (HPLC)
Packaging
5mg
Price
$108
Updated
2024/03/01
Sigma-Aldrich
Product number
PZ0336
Product name
TMI-1
Purity
≥98% (HPLC)
Packaging
25mg
Price
$174
Updated
2024/03/01
Cayman Chemical
Product number
29713
Product name
TMI 1
Packaging
5mg
Price
$153
Updated
2024/03/01
Cayman Chemical
Product number
29713
Product name
TMI 1
Packaging
10mg
Price
$275
Updated
2024/03/01
Tocris
Product number
5960
Product name
TMI1
Purity
≥98%(HPLC)
Packaging
10
Price
$265
Updated
2021/12/16
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TMI 1 Chemical Properties,Usage,Production

Description

TMI 1 is an inhibitor of disintegrin and metalloproteinase domain-containing protein 17 (ADAM17/TACE; IC50 = 8.4 nM in a cell-free enzyme assay). It inhibits matrix metalloproteinase-1 (MMP-1), -2, -7, -9, -13, and -14, as well as ADAM-TS-4 in vitro (IC50s = 6.6, 4.7, 26, 12, 3, 26, and 100 nM, respectively). It also inhibits ADAM8, -10, -12, and -17/TACE in cell-free enzyme assays with Ki values of 21, 16, 1.8, and 0.079 nM, respectively, with slow-binding inhibition of ADAM17/TACE but not the other ADAM enzymes. TMI 1 inhibits LPS-induced TNF-α secretion in Raw and THP-1 cells (IC50s = 40 and 200 nM, respectively), as well as in isolated human monocytes and whole blood (IC50s = 190 and 300 nM, respectively). It inhibits the production of TNF-α ex vivo in synovium isolated from the inflamed joints of patients with rheumatoid arthritis with IC50 values of less than 100 nM without inhibiting TNF-α expression in vitro. TMI 1 inhibits LPS-induced TNF-α production in mice (ED50 = 5 mg/kg) and reduces disease severity in mouse models of collagen-induced arthritis. It also decreases cell viability of (ED50s = 1.3-8.1 μM), and induces caspase-3/7 activity in, a variety of cancer cell lines and induces tumor apoptosis and reduces tumor growth in an MMTV-ErbB2/neu mouse model of breast cancer when administered at a dose of 100 mg/kg.

Uses

TMI 1 is a dual TACE/MMP inhibitor, which represents a unique class of orally bioavailable small molecule TNF inhibitors that may be effective and beneficial for treating rhuematoid arthritis.

storage

Store at -20°C

TMI 1 Preparation Products And Raw materials

Raw materials

Preparation Products

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TMI 1 Suppliers

China 20 Japan 1 United Kingdom 1 United States 6 Global 28
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9804
Advantage
58
Shanghai Hongye Biotechnology Co. Ltd
Tel
400-9205774
Email
sales@glpbio.cn
Country
China
ProdList
6777
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11218
Advantage
58
Energy Chemical
Tel
021-58432009 400-005-6266
Fax
021-58436166
Email
marketing@energy-chemical.com
Country
China
ProdList
44918
Advantage
58
Nantong Hi-Future Biotechnology Co., Ltd
Tel
18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3021
Advantage
58
Bide Pharmatech Ltd.
Tel
400-1647117 13681763483
Email
product02@bidepharm.com
Country
China
ProdList
62075
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2666
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58
Shanghai Aladdin Biochemical Technology Co.,Ltd.
Tel
400-6206333 18021050169
Email
market@aladdin-e.com
Country
China
ProdList
48460
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9266
Advantage
58
Tel
4008-099-669
Email
23419001name@qq.com
Country
CHINA
ProdList
73043
Advantage
58
R&D Systems, Inc
Tel
18003437475
Email
rdname@qq.com
Country
China
ProdList
35733
Advantage
58
Nantong HI-FUTURE Biology Co., Ltd.
Tel
+undefined18051384581
Email
sales@chemhifuture.com
Country
China
ProdList
3135
Advantage
58
Neobioscience Co., Ltd.
Tel
--
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Email
info@neobioscience.com
Country
CHINA
ProdList
6681
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
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Email
1985563437@qq.com
Country
CHINA
ProdList
6158
Advantage
58
Shanghai Haoyang Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
596799915@QQ.COM
Country
CHINA
ProdList
2905
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58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6025
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58
Xiamen Huijia Biological Technology Co., Ltd.
Tel
--
Fax
--
Country
CHINA
ProdList
6973
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58
Beijing Baiao Innovation Technology Co., Ltd.
Tel
--
Fax
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Email
3007606172@qq.com
Country
CHINA
ProdList
6002
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58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6648
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58

287403-39-8, TMI 1Related Search:


  • TMI 1
  • (3S)-4-[[4-(2-Butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-3-thiomorpholinecarboxamide
  • 3-Thiomorpholinecarboxamide, 4-[[4-(2-butyn-1-yloxy)phenyl]sulfonyl]-N-hydroxy-2,2-dimethyl-, (3S)-
  • TMI-1 >=98% (HPLC)
  • TMI 1,TMI1
  • (S)-4-((4-(But-2-yn-1-yloxy)phenyl)sulfonyl)-N-hydroxy-2,2-dimethylthiomorpholine-3-carboxamide
  • 287403-39-8