Difenidol
- Product Name
- Difenidol
- CAS No.
- 972-02-1
- Chemical Name
- Difenidol
- Synonyms
- Nometic;Vontrol;SKF 478;SK&F-478;Cephadol;DIFENIDOL;DIPHENIDOL;SK&F No. 478-A;Difenidol USP/EP/BP;1-Piperidinebutanol, α,α-diphenyl-
- CBNumber
- CB8474607
- Molecular Formula
- C21H27NO
- Formula Weight
- 309.45
- MOL File
- 972-02-1.mol
Difenidol Property
- Melting point:
- 104-105°
- Boiling point:
- 449.71°C (rough estimate)
- Density
- 1.0350 (rough estimate)
- refractive index
- 1.5614 (estimate)
- NIST Chemistry Reference
- Diphenidol(972-02-1)
Safety
- Hazardous Substances Data
- 972-02-1(Hazardous Substances Data)
- Toxicity
- LD50 s.c. in rats: 50 mg/kg (Goldenthal)
N-Bromosuccinimide Price
- Product number
- CHM0079965
- Product name
- DIFENIDOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $921.69
- Updated
- 2021/12/16
Difenidol Chemical Properties,Usage,Production
Originator
Vontrol,SKF,US,1967
Uses
Anti-emetic.
Definition
ChEBI: A tertiary alcohol that is butan-1-ol substituted by two phenyl groups at position 1 and a piperidin-1-yl group at position 4.
Manufacturing Process
2.6 grams magnesium, activated by means of iodine, is introduced into 20 cc
of absolute ether and is caused to react with 0.6 cc of ethyl
omide. While
warming gently, 16.2 grams (0.1 mol) of N-[1-chloropropyl-(3)]-piperidine in
40 cc of absolute ether are added and, after adding a further 0.5 cc of ethyl
omide, 14.5 grams (0.08 mol) of benzophenone in 50 cc of anhydrous ether
are added in portions. The magnesium is used up fairly quickly and, after 10
hours, only traces are left. In working up, both with hydrochloric acid and with
ammonium chloride, the hydrochloride of diphenyl-3-piperidinopropyl carbinol
is precipitated as a dense precipitate. It is purified by recrystallization from
chloroform-ethyl acetate. MP 212-214°C.
Therapeutic Function
Antinauseant
Trade name
Vontrol (Smith Kline & French), Cephadol (Nippon Shinyaku).
Difenidol Preparation Products And Raw materials
Raw materials
Preparation Products
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