ChemicalBook > CAS DataBase List > 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Product Name
4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
CAS No.
1957236-36-0
Chemical Name
4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Synonyms
Pomalidomide-NH2;Pomalidomide-C8-NH2;Thalidomide-NH-C8-NH2;Thalidomide-4-NH-C8-NH2;4-[(8-Aminooctyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione;4-((8-aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione;4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl;1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-;4-[(8-aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione;4-((8-aminooctyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
CBNumber
CB84796321
Molecular Formula
C21H28N4O4
Formula Weight
400.47
MOL File
1957236-36-0.mol
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Acrotein
Product number
AS00957
Product name
4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dioneHCl
Purity
97%
Packaging
1g
Price
$1466.67
Updated
2021/12/16
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4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties,Usage,Production

Description

Thalidomide-NH-C8-NH2 is a Thalidomide -based cereblon ligand with a linker, which is a useful precursor for synthesis of PROTAC degraders. Targeted protein degradation (TPD) is an emerging therapeutic modality with the potential to tackle disease-causing proteins that have historically been highly challenging to target with conventional small molecules. PROTAC degraders are usually heterobifunctional small molecules consisting of two ligands joined by a linker: one ligand recruits and binds a protein of interest (POI) while the other recruits and binds an E3 ubiquitin ligase. Simultaneous binding of the POI and ligase by the PROTAC induces ubiquitylation of the POI and its subsequent degradation by the ubiquitin–proteasome system (UPS), after which the PROTAC is recycled to target another copy of the POI.

4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Suppliers

China 18 United States 1 Global 19
Alfa Chemistry
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1-516-927-0118
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1957236-36-0, 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HClRelated Search:

POMALIDOMIDE-C9-CO2H Butanoic acid, 4-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]- 4-[(2-Aminoethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Pomalidomide-C3-NH2 Pomalidomide-C6-NH2?hydrochloride Heptanoic acid, 7-[[2-(2,6-dioxo-3-piperidinyl)-2,3-dihydro-1,3-dioxo-1H-isoindol-4-yl]amino]-

  • 4-[(8-Aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
  • 1H-Isoindole-1,3(2H)-dione, 4-[(8-aminooctyl)amino]-2-(2,6-dioxo-3-piperidinyl)-
  • Pomalidomide-NH2
  • Pomalidomide-C8-NH2
  • 4-((8-aminooctyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione hydrochloride
  • Thalidomide-NH-C8-NH2
  • 4-[(8-Aminooctyl)amino]-2-(2,6-dioxo-3-piperidyl)isoindoline-1,3-dione
  • Thalidomide-4-NH-C8-NH2
  • 4-[(8-aminooctyl)amino]-2-(2,6-dioxopiperidin-3-yl)-2,3-dihydro-1H-isoindole-1,3-dione
  • 4-((8-aminohexyl)amino)-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione
  • 1957236-36-0