ChemicalBook > CAS DataBase List > GT 949

GT 949

Product Name
GT 949
CAS No.
460330-27-2
Chemical Name
GT 949
Synonyms
GT 949;GT 949, 10 mM in DMSO;3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one;2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-
CBNumber
CB84844846
Molecular Formula
C30H37N7O2
Formula Weight
527.66
MOL File
460330-27-2.mol
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GT 949 Property

Boiling point:
770.7±60.0 °C(Predicted)
Density 
1.32±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mM; Ethanol: 10 mM, heated
form 
A solid
pka
10.55±0.70(Predicted)
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML2823
Product name
GT949
Purity
≥98% (HPLC)
Packaging
5 mg
Price
$78.18
Updated
2025/07/31
Sigma-Aldrich
Product number
SML2823
Product name
GT949
Purity
≥98% (HPLC)
Packaging
25 mg
Price
$268
Updated
2025/07/31
Tocris
Product number
6578
Product name
GT949
Purity
≥98%(HPLC)
Packaging
10
Price
$195
Updated
2021/12/16
Tocris
Product number
6578
Product name
GT949
Purity
≥98%(HPLC)
Packaging
50
Price
$806
Updated
2021/12/16
TRC
Product number
G800510
Product name
GT949
Packaging
2.5mg
Price
$200
Updated
2021/12/16
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GT 949 Chemical Properties,Usage,Production

Uses

GT 949 is a selective EAAT2 positive allosteric modulator (EC50 = 0.26 nM). Enhances the glutamate translocation rate, with no effect on substrate interaction. Increases glutamate removal by 70%. Exhibits no effect on DAT, SERT and NET or NMDA receptors.

Biological Activity

GT949 is a potent and selective positive allosteric modulator (PAM) of the excitatory amino acid transporter EAAT2 (glutamate uptake EC50 = 0.26 nM; COS-7 EAAT2 transfectant), but not EAAT1 or EAAT3. GT949 enhances glutamate uptake of cultured r at astrocytes (EC50 = 1 nM, Emax = 158%) with no potency toward human serotonin (SERT), noradrenaline (NET) and dopamine (DAT) transporters, nor NMDA receptors (murine primary cortical neurons).

IC 50

EAAT2

storage

Store at -20°C

GT 949 Preparation Products And Raw materials

Raw materials

Preparation Products

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GT 949 Suppliers

China 29 United Kingdom 1 United States 5 Global 35
Tocris Bioscience
Tel
--
Fax
--
Email
customerservice@tocris.co.uk
Country
United Kingdom
ProdList
5726
Advantage
77

460330-27-2, GT 949Related Search:


  • GT 949
  • 3-((4-Cyclohexylpiperazin-1-yl)(1-phenethyl-1H-tetrazol-5-yl)methyl)-6-methoxyquinolin-2(1H)-one
  • 2(1H)-Quinolinone, 3-[(4-cyclohexyl-1-piperazinyl)[1-(2-phenylethyl)-1H-tetrazol-5-yl]methyl]-6-methoxy-
  • GT 949, 10 mM in DMSO
  • 460330-27-2