MALAT1 inhibitor 5 (Malat1 inhibitor 5)

Product Name: MALAT1 inhibitor 5 (Malat1 inhibitor 5)
CAS No.: 827327-28-6
Chemical Name: MALAT1 inhibitor 5 (Malat1 inhibitor 5)
Synonyms: TC SL C5;MALAT1-IN-5;MALAT1 inhibitor 1;MALAT1 inhibitor 5;MALAT1-IN-1, 10 mM in DMSO;MALAT1 inhibitor 5 (Malat1 inhibitor 5);MALAT1 IN 1,inhibit,MALAT1IN1,Inhibitor,MALAT-1-IN-1;N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine;5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-imidazol-2-amine;1H-Imidazol-2-amine, 5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-
CBNumber: CB84845010
Molecular Formula: C19H21N3O2
Formula Weight: 323.39
MOL File: 827327-28-6.mol

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MALAT1 inhibitor 5 (Malat1 inhibitor 5) Property

Boiling point:: 534.0±60.0 °C(Predicted)
Density: 1.14±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO: 125 mg/mL (386.53 mM)
pka: 7.50±0.25(Predicted)
form: Solid
color: Light yellow to khaki

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Tocris

Product number: 6884
Product name: TCSLC5
Purity: ≥98%(HPLC)
Packaging: 10
Price: $89
Updated: 2021/12/16

Arctom

Product number: AS709140
Product name: N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine
Purity: 98%
Packaging: 10mg
Price: $134
Updated: 2021/12/16

Ambeed

Product number: A1216706
Product name: N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine
Purity: 98%
Packaging: 10mg
Price: $135
Updated: 2021/12/16

Arctom

Product number: AS709140
Product name: N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine
Purity: 98%
Packaging: 25mg
Price: $317
Updated: 2021/12/16

Ambeed

Product number: A1216706
Product name: N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine
Purity: 98%
Packaging: 25mg
Price: $320
Updated: 2021/12/16

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MALAT1 inhibitor 5 (Malat1 inhibitor 5) Chemical Properties,Usage,Production

Uses

MALAT1-IN-1 (compounds 5) is a potent and specific Malat1 (Metastasis-associated lung adenocarcinoma transcript 1) inhibitor. MALAT1-IN-1 modulated Malat1 downstream genes in a dose-dependent manner without affecting expression of nuclear enriched abundant transcript 1 (Neat1) [1].

Biological Activity

MALAT1-IN-5 reduces the long noncoding (lnc) RNA metastasis-associated lung adenocarcinoma transcript 1 (Malat1) level (by 54% in 7 days at 1 μM; MMTV-PyMT tumors organoids) via specific interaction with Malat1 triple-helical configuration of 3μ-terminal element for nuclear expression (ENE KD = 2.9 μM under physiologic ionic conditions), but not the homologous 3μ-end triple-helix of Neat1 (MENβ) lncRNA. MALAT1-IN-5 decreases MMTV-PyMT organoid branching morphogenesis (by 38% in 7 days at 1 μM) and modulates the levels of Malat1-targeted mRNAs Krt16 & Csn2.

storage

Store at -20°C

References

[1] Abulwerdi FA, et al. Selective Small-Molecule Targeting of a Triple Helix Encoded by the Long Noncoding RNA, MALAT1. ACS Chem Biol. 2019 Feb 15;14(2):223-235. DOI:10.1021/acschembio.8b00807

MALAT1 inhibitor 5 (Malat1 inhibitor 5) Preparation Products And Raw materials

Raw materials

Preparation Products

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MALAT1 inhibitor 5 (Malat1 inhibitor 5) Suppliers

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827327-28-6, MALAT1 inhibitor 5 (Malat1 inhibitor 5)Related Search:

MALAT1 inhibitor 5 (Malat1 inhibitor 5)

TC SL C5

MALAT1 inhibitor 1

1H-Imidazol-2-amine, 5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-

MALAT1 inhibitor 5

N-(3-Methoxybenzyl)-5-(4-methoxyphenyl)-1-methyl-1H-imidazol-2-amine

MALAT1 IN 1,inhibit,MALAT1IN1,Inhibitor,MALAT-1-IN-1

5-(4-methoxyphenyl)-N-[(3-methoxyphenyl)methyl]-1-methyl-1H-imidazol-2-amine

MALAT1-IN-1, 10 mM in DMSO

MALAT1-IN-5

827327-28-6