ChemicalBook > CAS DataBase List > N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Product Name
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
CAS No.
1421448-26-1
Chemical Name
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Synonyms
GN 44028;4-dihydroindeno[1;2-c]pyrazol-3-amine;4-benzodioxin-6-yl)-1;GN44028, 10 mM in DMSO;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H,4H-indeno[1,2-c]pyrazol-3-amine;N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-;N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;GN 44028,colorectal cancer,HIFs,Hypoxia,HeLa,ME23,GSCs,HIF/HIF Prolyl-Hydroxylase,inhibit,GN-44028,HCT116,cancer,heterodimerization,HIF-PH,GN44028,Hypoxia-inducible factors,PN12,Inhibitor
CBNumber
CB84902788
Molecular Formula
C18H15N3O2
Formula Weight
305.33
MOL File
1421448-26-1.mol
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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Property

Melting point:
144 - 148oC
Boiling point:
543.7±50.0 °C(Predicted)
Density 
1.421±0.06 g/cm3(Predicted)
storage temp. 
-20°C Freezer, Under inert atmosphere
solubility 
Chloroform (Slightly), Methanol (Slightly)
pka
14.30±0.20(Predicted)
form 
Solid
color 
Pale Brown
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris
Product number
5655
Product name
GN44028
Purity
≥98%(HPLC)
Packaging
10
Price
$210
Updated
2021/12/16
TRC
Product number
G766315
Product name
GN44028
Packaging
1mg
Price
$100
Updated
2021/12/16
TRC
Product number
G766315
Product name
GN44028
Packaging
5mg
Price
$375
Updated
2021/12/16
ChemScene
Product number
CS-0033132
Product name
GN44028
Purity
>99.0%
Packaging
5mg
Price
$280
Updated
2021/12/16
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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Chemical Properties,Usage,Production

Uses

GN 44028 is a potent HIF-1α inhibitor.

Biological Activity

Cell permeable: yes', 'Primary Target
HIF-1α', 'Reversible: yes', 'Secondary Target
VEGF', 'Target IC50: 14 nM in HRE-Luc HeLa cells

in vivo

GN44028 (10 mg/kg, oral gavage) extends the survival rate of animals in mice bearing a mixed orthotopic tumor with PN12 and ME23 cells[3].
GN44028 (5 mg/kg, tail vein injection, twice a week) suppresses tumor growth in a subcutaneous colorectal cancer model[2].

Animal Model:Mice bearing a mixed orthotopic tumor with PN12 and ME23 cells[3]
Dosage:10 mg/kg
Administration:Oral gavage
Result:Reduced both proneural and mesenchymal markers.
Animal Model:Subcutaneous colorectal cancer model (HCT116)[2]
Dosage:5 mg/kg
Administration:Tail vein injection, twice a week
Result:Reduced pulmonary nodules in tumor-bearing mice, and enhanced the outcome of chemotherapy.

storage

Store at +4°C

N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Suppliers

China 30 United Kingdom 1 United States 4 Global 35
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1421448-26-1, N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amineRelated Search:


  • N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
  • GN 44028
  • Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-
  • 2-c]pyrazol-3-amine
  • 4-benzodioxin-6-yl)-1
  • 4-dihydroindeno[1
  • GN 44028,colorectal cancer,HIFs,Hypoxia,HeLa,ME23,GSCs,HIF/HIF Prolyl-Hydroxylase,inhibit,GN-44028,HCT116,cancer,heterodimerization,HIF-PH,GN44028,Hypoxia-inducible factors,PN12,Inhibitor
  • N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
  • N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H,4H-indeno[1,2-c]pyrazol-3-amine
  • GN44028, 10 mM in DMSO
  • 1421448-26-1