N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

Product Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
CAS No.: 1421448-26-1
Chemical Name: N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
Synonyms: GN 44028;4-dihydroindeno[1;2-c]pyrazol-3-amine;4-benzodioxin-6-yl)-1;GN44028, 10 mM in DMSO;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H,4H-indeno[1,2-c]pyrazol-3-amine;N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-;N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;GN 44028,colorectal cancer,HIFs,Hypoxia,HeLa,ME23,GSCs,HIF/HIF Prolyl-Hydroxylase,inhibit,GN-44028,HCT116,cancer,heterodimerization,HIF-PH,GN44028,Hypoxia-inducible factors,PN12,Inhibitor
CBNumber: CB84902788
Molecular Formula: C18H15N3O2
Formula Weight: 305.33
MOL File: 1421448-26-1.mol

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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Property

Melting point:: 144 - 148oC
Boiling point:: 543.7±50.0 °C(Predicted)
Density: 1.421±0.06 g/cm3(Predicted)
storage temp.: -20°C Freezer, Under inert atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: 14.30±0.20(Predicted)
form: Solid
color: Pale Brown

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Tocris

Product number: 5655
Product name: GN44028
Purity: ≥98%(HPLC)
Packaging: 10
Price: $210
Updated: 2021/12/16

TRC

Product number: G766315
Product name: GN44028
Packaging: 1mg
Price: $100
Updated: 2021/12/16

TRC

Product number: G766315
Product name: GN44028
Packaging: 5mg
Price: $375
Updated: 2021/12/16

ChemScene

Product number: CS-0033132
Product name: GN44028
Purity: >99.0%
Packaging: 5mg
Price: $280
Updated: 2021/12/16

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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Chemical Properties,Usage,Production

Uses

GN 44028 is a potent HIF-1α inhibitor.

Biological Activity

Cell permeable: yes', 'Primary Target
HIF-1α', 'Reversible: yes', 'Secondary Target
VEGF', 'Target IC50: 14 nM in HRE-Luc HeLa cells

in vivo

GN44028 (10 mg/kg, oral gavage) extends the survival rate of animals in mice bearing a mixed orthotopic tumor with PN12 and ME23 cells^[3].
GN44028 (5 mg/kg, tail vein injection, twice a week) suppresses tumor growth in a subcutaneous colorectal cancer model^[2].

Animal Model:	Mice bearing a mixed orthotopic tumor with PN12 and ME23 cells^[3]
Dosage:	10 mg/kg
Administration:	Oral gavage
Result:	Reduced both proneural and mesenchymal markers.

Animal Model:	Subcutaneous colorectal cancer model (HCT116)^[2]
Dosage:	5 mg/kg
Administration:	Tail vein injection, twice a week
Result:	Reduced pulmonary nodules in tumor-bearing mice, and enhanced the outcome of chemotherapy.

storage

Store at +4°C

N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Suppliers

China 30 United Kingdom 1 United States 4 Global 35

ShangHai Caerulum Pharma Discovery Co., Ltd.

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TargetMol Chemicals Inc.

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Hebei Weite Medical Technology Co., Ltd

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Beijing Jin Ming Biotechnology Co., Ltd.

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Wuhan Augda Biotechnology Co., Ltd

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1421448-26-1, N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amineRelated Search:

N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

GN 44028

Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-

2-c]pyrazol-3-amine

4-benzodioxin-6-yl)-1

4-dihydroindeno[1

GN 44028,colorectal cancer,HIFs,Hypoxia,HeLa,ME23,GSCs,HIF/HIF Prolyl-Hydroxylase,inhibit,GN-44028,HCT116,cancer,heterodimerization,HIF-PH,GN44028,Hypoxia-inducible factors,PN12,Inhibitor

N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine

N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H,4H-indeno[1,2-c]pyrazol-3-amine

GN44028, 10 mM in DMSO

1421448-26-1