ChemicalBook > CAS DataBase List > N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
- Product Name
- N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
- CAS No.
- 1421448-26-1
- Chemical Name
- N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine
- Synonyms
- GN 44028;4-dihydroindeno[1;2-c]pyrazol-3-amine;4-benzodioxin-6-yl)-1;GN44028, 10 mM in DMSO;N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H,4H-indeno[1,2-c]pyrazol-3-amine;N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;Indeno[1,2-c]pyrazol-3-amine, N-(2,3-dihydro-1,4-benzodioxin-6-yl)-1,4-dihydro-;N-(2,3-Dihydrobenzo[b][1,4]dioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine;GN 44028,colorectal cancer,HIFs,Hypoxia,HeLa,ME23,GSCs,HIF/HIF Prolyl-Hydroxylase,inhibit,GN-44028,HCT116,cancer,heterodimerization,HIF-PH,GN44028,Hypoxia-inducible factors,PN12,Inhibitor
- CBNumber
- CB84902788
- Molecular Formula
- C18H15N3O2
- Formula Weight
- 305.33
- MOL File
- 1421448-26-1.mol
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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Property
- Melting point:
- 144 - 148oC
- Boiling point:
- 543.7±50.0 °C(Predicted)
- Density
- 1.421±0.06 g/cm3(Predicted)
- storage temp.
- -20°C Freezer, Under inert atmosphere
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 14.30±0.20(Predicted)
- form
- Solid
- color
- Pale Brown
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N-Bromosuccinimide Price
Tocris
- Product number
- 5655
- Product name
- GN44028
- Purity
- ≥98%(HPLC)
- Packaging
- 10
- Price
- $210
- Updated
- 2021/12/16
TRC
- Product number
- G766315
- Product name
- GN44028
- Packaging
- 1mg
- Price
- $100
- Updated
- 2021/12/16
TRC
- Product number
- G766315
- Product name
- GN44028
- Packaging
- 5mg
- Price
- $375
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0033132
- Product name
- GN44028
- Purity
- >99.0%
- Packaging
- 5mg
- Price
- $280
- Updated
- 2021/12/16
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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Chemical Properties,Usage,Production
Uses
GN 44028 is a potent HIF-1α inhibitor.
Biological Activity
Cell permeable: yes', 'Primary Target
HIF-1α', 'Reversible: yes', 'Secondary Target
VEGF', 'Target IC50: 14 nM in HRE-Luc HeLa cells
in vivo
GN44028 (10 mg/kg, oral gavage) extends the survival rate of animals in mice bearing a mixed orthotopic tumor with PN12 and ME23 cells[3].
GN44028 (5 mg/kg, tail vein injection, twice a week) suppresses tumor growth in a subcutaneous colorectal cancer model[2].
| Animal Model: | Mice bearing a mixed orthotopic tumor with PN12 and ME23 cells[3] |
| Dosage: | 10 mg/kg |
| Administration: | Oral gavage |
| Result: | Reduced both proneural and mesenchymal markers. |
| Animal Model: | Subcutaneous colorectal cancer model (HCT116)[2] |
| Dosage: | 5 mg/kg |
| Administration: | Tail vein injection, twice a week |
| Result: | Reduced pulmonary nodules in tumor-bearing mice, and enhanced the outcome of chemotherapy. |
storage
Store at +4°C
N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Preparation Products And Raw materials
Raw materials
Preparation Products
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N-(2,3-Dihydro-1,4-benzodioxin-6-yl)-1,4-dihydroindeno[1,2-c]pyrazol-3-amine Suppliers
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