ChemicalBook > CAS DataBase List > Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

Product Name
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
CAS No.
1606974-33-7
Chemical Name
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
Synonyms
BPN14770;Zatolmilast;Zatolmilast (BPN14770);Zatolmilast, 10 mM in DMSO;Zatolmilast (BPN14770) ，S6844;Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit;2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid;Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
CBNumber
CB85552252
Molecular Formula
C21H15ClF3NO2
Formula Weight
405.8
MOL File
1606974-33-7.mol
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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Property

Boiling point:
514.4±50.0 °C(Predicted)
Density 
1.351±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 260 mg/mL (640.71 mM)
pka
4.27±0.10(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon3148
Product name
BPN14770
Purity
99%
Packaging
5mg
Price
$132
Updated
2021/12/16
Axon Medchem
Product number
Axon3148
Product name
BPN14770
Purity
99%
Packaging
2x5mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0066529
Product name
BPN14770
Purity
99.39%
Packaging
5mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-0066529
Product name
BPN14770
Purity
99.39%
Packaging
10mg
Price
$520
Updated
2021/12/16
ChemScene
Product number
CS-0066529
Product name
BPN14770
Purity
99.39%
Packaging
25mg
Price
$990
Updated
2021/12/16
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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Chemical Properties,Usage,Production

Uses

Zatolmilast is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor for the treatment of fragile X syndrome and other brain disorders.

in vivo

Zatolmilast increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].
Zatolmilast (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].

Animal Model:C57Bl6 mice[2]
Dosage:0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:p.o.; 24hours
Result:Significantly improved novel object discrimination at doses above 0.3 mg/kg.

IC 50

PDE4D3: 7.4 nM (IC50); PDE4D7: 7.8 nM (IC50)

Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Suppliers

China 41 United States 3 Global 44
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1136
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64
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185;
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3505
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58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4810
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55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2536
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55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
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58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71615
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9023
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Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29661
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68
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32469
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58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1115
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58
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View Lastest Price from Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
BPN14770 1606974-33-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2025-08-31

1606974-33-7, Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-Related Search:


  • Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
  • BPN14770
  • Zatolmilast
  • Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit
  • 2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid
  • Zatolmilast, 10 mM in DMSO
  • Zatolmilast (BPN14770)
  • Zatolmilast (BPN14770) ，S6844
  • 1606974-33-7
  • C21H15ClF3NO2