ChemicalBook > CAS DataBase List > Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-

Product Name
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
CAS No.
1606974-33-7
Chemical Name
Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
Synonyms
BPN14770;Zatolmilast;Zatolmilast (BPN14770);Zatolmilast, 10 mM in DMSO;Zatolmilast (BPN14770) ，S6844;Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit;2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid;Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
CBNumber
CB85552252
Molecular Formula
C21H15ClF3NO2
Formula Weight
405.8
MOL File
1606974-33-7.mol
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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Property

Boiling point:
514.4±50.0 °C(Predicted)
Density 
1.351±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 260 mg/mL (640.71 mM)
pka
4.27±0.10(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Axon Medchem
Product number
Axon3148
Product name
BPN14770
Purity
99%
Packaging
5mg
Price
$132
Updated
2021/12/16
Axon Medchem
Product number
Axon3148
Product name
BPN14770
Purity
99%
Packaging
2x5mg
Price
$220
Updated
2021/12/16
ChemScene
Product number
CS-0066529
Product name
BPN14770
Purity
99.39%
Packaging
5mg
Price
$280
Updated
2021/12/16
ChemScene
Product number
CS-0066529
Product name
BPN14770
Purity
99.39%
Packaging
10mg
Price
$520
Updated
2021/12/16
ChemScene
Product number
CS-0066529
Product name
BPN14770
Purity
99.39%
Packaging
25mg
Price
$990
Updated
2021/12/16
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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Chemical Properties,Usage,Production

Uses

Zatolmilast is a selective phosphodiesterase 4D (PDE4D) allosteric inhibitor for the treatment of fragile X syndrome and other brain disorders.

in vivo

Zatolmilast increases brain cAMP, increases phosphorylation of CREB and increases production of brain-derived neurotrophic factor (BDNF) in hippocampus[1].
? Zatolmilast (0.1-30 mg/kg; p.o.; 24 hours) provides cognitive benefit in the mouse novel object recognition (NOR) at doses above 0.3 mg/kg[2].

Animal Model:C57Bl6 mice[2]
Dosage:0.1, 0.3, 1, 3, 10, 30 mg/kg
Administration:p.o.; 24?hours
Result:Significantly improved novel object discrimination at doses above 0.3 mg/kg.

IC 50

PDE4D3: 7.4 nM (IC50); PDE4D7: 7.8 nM (IC50)

Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- Suppliers

China 41 United States 3 Global 44
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd.
Tel
17702719238 18971495150;
Email
sales@sun-shinechem.com
Country
China
ProdList
1077
Advantage
64
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3506
Advantage
58
Shanghai Lollane Biological Technology Co.,Ltd.
Tel
021-52996696，15000506266 15000506266
Fax
+86-21-52996696
Country
China
ProdList
4757
Advantage
55
Shanghai Beckham Medical Technology Co., Ltd
Tel
13816613772
Fax
QQ: 12922499
Email
huahero21@sina.com
Country
China
ProdList
2391
Advantage
55
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9803
Advantage
58
Shanghai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847; 18021002903
Fax
QQ:3008007432
Email
3008007409@qq.com
Country
China
ProdList
71826
Advantage
60
Shanghai Chaolan Chemical Technology Center
Tel
021-QQ：65489617 15618227136
Fax
21-5161 9052
Email
Sales@ATKchemical.com
Country
China
ProdList
9126
Advantage
58
Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973130 18101056239
Email
3193328036@qq.com
Country
China
ProdList
29760
Advantage
68
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
Shanghai Dongyang Biotechnology Co., Ltd.
Tel
0512-0512-13601744364 13601744364
Email
chemsharker@126.com
Country
China
ProdList
1010
Advantage
58
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View Lastest Price from Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]- manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
BPN14770 1606974-33-7
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2025-08-31

1606974-33-7, Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-Related Search:


  • Benzeneacetic acid, 4-[[2-(3-chlorophenyl)-6-(trifluoromethyl)-4-pyridinyl]methyl]-
  • BPN14770
  • Zatolmilast
  • Zatolmilast,Phosphodiesterase (PDE),BPN-14770,Inhibitor,BPN 14770,inhibit
  • 2-(4-{[2-(3-chlorophenyl)-6-(trifluoromethyl)pyridin-4-yl]methyl}phenyl)acetic acid
  • Zatolmilast, 10 mM in DMSO
  • Zatolmilast (BPN14770)
  • Zatolmilast (BPN14770) ，S6844
  • 1606974-33-7
  • C21H15ClF3NO2