ChemicalBook > CAS DataBase List > 4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE

4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE

Product Name: 4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE
CAS No.: 1511-16-6
Chemical Name: 4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE
Synonyms: HALOPERIDOL HYDROCHLORIDE;4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE;4-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one hydrochloride;1-Butanone,4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-,hydrochloride
CBNumber: CB8698775
Molecular Formula: C21H24Cl2FNO2
Formula Weight: 412.33
MOL File: Mol file

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4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE Property

Melting point:: 226-227.5°
storage temp.: Store at -20°C
solubility: insoluble in H2O; ≥10.31 mg/mL in DMSO; ≥2.96 mg/mL in EtOH with gentle warming and ultrasonic
form: solid

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H301Toxic if swalloed

H315Causes skin irritation

H317May cause an allergic skin reaction

H319Causes serious eye irritation

H335May cause respiratory irritation

H361Suspected of damaging fertility or the unborn child

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P272Contaminated work clothing should not be allowed out of the workplace.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P321Specific treatment (see … on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Tocris

Product number: 0931
Product name: Haloperidolhydrochloride
Purity: ≥99%(HPLC)
Packaging: 100
Price: $87
Updated: 2021/12/16

TRC

Product number: H103760
Product name: HaloperidolHydrochloride
Packaging: 10g
Price: $1050
Updated: 2021/12/16

ApexBio Technology

Product number: B1242
Product name: Haloperidolhydrochloride
Packaging: 1g
Price: $137
Updated: 2021/12/16

ApexBio Technology

Product number: B1242
Product name: Haloperidolhydrochloride
Packaging: 10mM(in 1mL DMSO)
Price: $50
Updated: 2021/12/16

ApexBio Technology

Product number: B1242
Product name: Haloperidolhydrochloride
Packaging: 500mg
Price: $73
Updated: 2021/12/16

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4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE Chemical Properties,Usage,Production

Uses

Haloperidol Hydrochloride is the salt analogue of Haloperidol (H103700) a dopamine inverse agonist, antidyskinetic and antipsychotic agent.

Biological Activity

haloperidol hydrochloride is an antipsychotic drug that has similar actions to the antipsychotic medicine phenothiazine [1].haloperidol hydrochloride has been reported to play a role as an inverse agonist of dopamine. in addition, haloperidol hydrochloride has been found to be highlt potent neuroleptic by relieving nervous through the depression of nerve function. besides, haloperidol hydrochloride has shown about 50-fold potency than chiorpromazine, the other antipsychotic drug. haloperidol hydrochloride has shown beneficial effects in the treatment of delusions and hallucinations. these effects are mainly achieved through blockage of dopamine receptors in the mesocortex and limbic system. haloperidol hydrochloride has been revealed to prevent the effects of dopamine in the nigrostriatal pathways, which probably explains the associated side effects such as akathisia and dystonias[1].

in vivo

Haloperidol (1 mg) intra-arterially attenuates the dopamine-induced pancreatic secretion. Haloperidol (3 mg) completely inhibits the action of 10 μg of dopamine in the pancreas of the dogs^[1]. Haloperidol (10 mg/kg) as well as chlorpromazine (CPZ, 15 mg/kg) blocks mescaline-induced altered behavior within 7 to 10 minutes when injected into the mice 45 minutes after 50 mg/kg (2 μc) of mescaline. Haloperidol has no effect on mescaline disappearance^[2].

IC 50

D₂ Receptor

storage

Room temperature

References

[1] dr ananya mandal, md .haloperidol pharmacology.

4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE Preparation Products And Raw materials

Raw materials

Preparation Products

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4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE Suppliers

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1511-16-6, 4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDERelated Search:

Haloperidol β-D-Glucuronide Haloperidol PIPERAZINE DIHYDROCHLORIDE Flavoxate hydrochloride

4-[4-(4-CHLOROPHENYL)-4-HYDROXY-1-PIPERIDINYL]-1-(4-FLUOROPHENYL)-1-BUTANONE HYDROCHLORIDE

HALOPERIDOL HYDROCHLORIDE

4-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-1-(4-fluorophenyl)butan-1-one hydrochloride

1-Butanone,4-[4-(4-chlorophenyl)-4-hydroxy-1-piperidinyl]-1-(4-fluorophenyl)-,hydrochloride

1511-16-6

C21H24Cl2FNO2

Aromatics, Heterocycles, Pharmaceuticals, Intermediates & Fine Chemicals