ChemicalBook > CAS DataBase List > 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE

1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE

Product Name
1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE
CAS No.
33941-15-0
Chemical Name
1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE
Synonyms
AZA-18-CROWN-6;1-AZA-18-CROWN-6;Aza-18-crown-6,98%;1-AZA-18-CROWN 6-ETHER;1-Aza-18-crown-6, ≥98%;1-Aza-18-crown 6-Ether >1-Aza-18-crown-6 >=98.0% (NT);PENTAOXA-16-AZACYCLOOCTADECANE;4,7,10,13,16-Pentaoxa-1-azacyclooctadecane;1-Aza-4,7,10,13,16-pentaoxacyclooctadecane
CBNumber
CB8723167
Molecular Formula
C12H25NO5
Formula Weight
263.33
MOL File
33941-15-0.mol
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1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE Property

Melting point:
46-49 °C (lit.)
Boiling point:
406.57°C (rough estimate)
Density 
1.1122 (rough estimate)
refractive index 
1.4287 (estimate)
Flash point:
>230 °F
storage temp. 
Keep in dark place,Inert atmosphere,Room temperature
pka
8.69±0.20(Predicted)
form 
powder to crystaline
color 
White to Light yellow to Light orange
Water Solubility 
Insoluble in water.
Sensitive 
Air Sensitive
BRN 
1074079
CAS DataBase Reference
33941-15-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
F 
3-10
HS Code 
29349990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
11382
Product name
1-Aza-18-crown-6
Purity
≥98.0% (NT)
Packaging
1g
Price
$429
Updated
2025/07/31
Sigma-Aldrich
Product number
11382
Product name
1-Aza-18-crown-6
Purity
≥98.0% (NT)
Packaging
5g
Price
$1830
Updated
2025/07/31
TCI Chemical
Product number
A1324
Product name
1-Aza-18-crown 6-Ether
Purity
>98.0%(GC)
Packaging
1g
Price
$276
Updated
2025/07/31
TCI Chemical
Product number
A1324
Product name
1-Aza-18-crown 6-Ether
Purity
>98.0%(GC)
Packaging
5g
Price
$1084
Updated
2025/07/31
TRC
Product number
P227453
Product name
1,4,7,10,13-Pentaoxa-16-azacyclooctadecane
Packaging
50mg
Price
$60
Updated
2021/12/16
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1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystals or crystalline mass

Uses

1-Aza-18-crown-6 is used as building block for the synthesis of bis-crown ethers, lariat ethers and other monofunctionalized macrocycles. It is also used as pharmaceutical intermediate.

Synthesis

37860-51-8

111-42-2

33941-15-0

To a 3L three-necked round-bottomed flask was sequentially added a magnetic stirrer, 1.50 L of tert-butanol (tBuOH) and potassium tert-butanol (KOtBu, 30.7 g, 274 mmol). The mixture was heated to 40 °C with continuous stirring for 30 min to ensure complete dissolution of KOtBu. Subsequently, tetraethylene glycol di-p-toluenesulfonate (46 g, 91.5 mmol, dissolved in 100 mL of dioxane) and diethanolamine (9.6 g, 91.3 mmol, dissolved in 100 mL of tBuOH), respectively, were slowly added dropwise to the reaction system over a period of 2 hours through two different dropping funnels. Note: The rate of titration has a significant effect on the reaction yield, and slow titration helps to increase the yield. After dropwise addition, the reaction mixture was continued to be stirred for 1 hour and subsequently cooled to room temperature. The reaction mixture was filtered through a Brinell funnel and the solvent was removed by rotary evaporator. To the residual brown viscous mass was added 100 mL of deionized water and extracted first with hexane (1 x 60 mL, discarding the hexane phase) and then with dichloromethane (CH2Cl2, 5 x 60 mL). The dichloromethane phases were combined, dried with anhydrous magnesium sulfate (MgSO4) and the solvent was again removed by rotary evaporator. The resulting dark brown residue was distilled under high vacuum through a ball-bulb distillation apparatus using a hot air gun for assisted heating, resulting in the colorless liquid-like product az-18-crown ether-6 (8.4 g, 35% yield). The nuclear magnetic resonance (NMR) spectrum of the product was consistent with the data reported in the literature. It was found that the tBuOH used in the reaction could be recovered by distillation and used in the subsequent synthesis of aza-crown ether even though it contained a small amount of dioxane (<5%).

References

[1] Bulletin of the Chemical Society of Japan, 1983, vol. 56, # 1, p. 212 - 218
[2] Polyhedron, 2018, vol. 141, p. 385 - 392
[3] Phosphorus, Sulfur and Silicon and the Related Elements, 2006, vol. 181, # 1, p. 219 - 225
[4] Journal of the Chemical Society, Chemical Communications, 1981, # 10, p. 471 - 472

1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE Preparation Products And Raw materials

Raw materials

Preparation Products

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1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE Suppliers

Americas 1 Belgium 1 China 82 Europe 1 Germany 2 India 4 Japan 3 South Korea 1 Switzerland 1 The Netherlands 1 United Kingdom 6 United States 6 Global 109
J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
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China
ProdList
96815
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Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
4006356688 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
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China
ProdList
40228
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Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
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China
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24529
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Beijing HwrkChemical Technology Co., Ltd
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18515581800 18501085097
Fax
010-89508210
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sales.bj@hwrkchemical.com
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China
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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44801
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Shanghai Hanhong Scientific Co.,Ltd.
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021-54306202 13764082696
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info@hanhongsci.com
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China
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42934
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Shandong Xiya Chemical Co., Ltd
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4009903999 13355009207
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0539-6365991
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3007715519@qq.com
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China
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18729
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Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
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China
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12984
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Tianjin heowns Biochemical Technology Co., Ltd.
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400 638 7771
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sales@heowns.com
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China
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View Lastest Price from 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
PENTAOXA-16-AZACYCLOOCTADECANE 33941-15-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
20T
Release date
2024-08-15
Career Henan Chemical Co
Product
1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE 33941-15-0
Price
US $3.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
100kg
Release date
2019-07-09

33941-15-0, 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANERelated Search:

Aza-15-crown-5 18-Crown-6 Isobutyl iodide 4,13-Diaza-18-crown 6-ether 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE 2-[2-(2-AMINOETHOXY)ETHOXY]ETHANOL 1-AMINO-3,6,9-TRIOXAUNDECANYL-11-OL N-METHOXYMETHYLAZA-18-CROWN-6, 96 (14R*,18R*)-14,18-dimethyl-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 16-[2-(2-Methoxyethoxy)ethyl]-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 16-(2-Methoxyethyl)-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 16,16'-Pentamethylenebis(1,4,7,10,13-pentaoxa-16-azacyclooctadecane) 16-[(4-methylphenyl)sulfonyl]-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 16,16'-[Oxybis(ethylene)]bis[1,4,7,10,13-pentaoxa-16-azacyclooctadecane] 16-Heptyl-1,4,7,10,13-pentaoxa-16-azacyclooctadecane (14S,18S)-14,18-Dimethyl-1,4,7,10,13-pentaoxa-16-azacyclooctadecane 1,4,7,10,13-pentaoxa-16-azacyclooctadecane-16-carbonitrile 6-AMINO-1-(1,4,7,10,13-PENTAOXA-16-AZA-CYCLOOCTADEC-16-YL)-HEXAN-1-ONE

  • 1,4,7,10,13-PENTAOXA-16-AZACYCLOOCTADECANE
  • 1-AZA-18-CROWN-6
  • 1-AZA-18-CROWN 6-ETHER
  • AZA-18-CROWN-6
  • 1-Aza-4,7,10,13,16-pentaoxacyclooctadecane
  • 4,7,10,13,16-Pentaoxa-1-azacyclooctadecane
  • Aza-18-crown-6,98%
  • 1-Aza-18-crown-6 >=98.0% (NT)
  • 1-Aza-18-crown 6-Ether &gt
  • 1-Aza-18-crown-6, ≥98%
  • PENTAOXA-16-AZACYCLOOCTADECANE
  • 33941-15-0
  • 3941-15-0
  • 33914-15-0
  • C12H25NO5
  • Chelation/Complexation Compounds
  • Azacrown Ethers
  • Macrocycles for Host-Guest Chemistry
  • Crown Ethers
  • Synthetic Reagents
  • Azacrown Ethers
  • Crown Ethers
  • Functional Materials
  • Macrocycles for Host-Guest Chemistry
  • organic building block