PROTAC IRAK4 degrader-1

Product Name: PROTAC IRAK4 degrader-1
CAS No.: 2360533-90-8
Chemical Name: PROTAC IRAK4 degrader-1
Synonyms: PROTAC IRAK4 degrader-1;2-{2-[(cyclopropylmethyl)amino]pyridin-4-yl}-N-{1-[4-({3-[4-({[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}methyl)-1H-imidazol-1-yl]propyl}carbamoyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-1,3-oxazole-4-carboxamide
CBNumber: CB88054605
Molecular Formula: C44H39F3N12O7
Formula Weight: 904.85
MOL File: Mol file

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PROTAC IRAK4 degrader-1 Property

Density: 1.61±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
pka: 10.74±0.40(Predicted)
form: Solid
color: White to yellow

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Hazard and Precautionary Statements (GHS)

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PROTAC IRAK4 degrader-1 Chemical Properties,Usage,Production

Biological Activity

PROTAC IRAK4 degrader-1 is a PROTAC interleukin-1 receptor-associated kinase 4 (IRAK4) degrader extracted from patent US20190192668A1 Compound I-210, makes 20-50%, and >50% IRAK4 degradation at 0.01, 0.1, and 1 μM in OCI-LY-10 cells, respectively[1].

References

[1]. Nello Mainolfi, et al. Irak degraders and uses thereof. US20190192668A1.

PROTAC IRAK4 degrader-1 Preparation Products And Raw materials

Raw materials

Preparation Products

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PROTAC IRAK4 degrader-1 Suppliers

China 5 United States 1 Global 6

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7887
Advantage: 56

Jilin Province Woda Biotechnology Co., Ltd.

Tel: 13504435624
Email: 1927928688@qq.com
Country: China
ProdList: 1456
Advantage: 58

Changzhou Bojia Biomedical Technology Co., Ltd.

Tel: 2122619822
Email: czbjpharma@126.com
Country: China
ProdList: 18478
Advantage: 58

ShenZhen Trendseen Biological Technology Co.,Ltd.

Tel: 13417589054 13417589054
Email: trendseenbio@gmail.com
Country: China
ProdList: 9470
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Nantong QuanYi Biotechnology Co., Ltd

Tel: 0513-66337626 18051384581
Email: sales@chemhifuture.com
Country: China
ProdList: 4933
Advantage: 58

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PROTAC IRAK4 degrader-1

2-{2-[(cyclopropylmethyl)amino]pyridin-4-yl}-N-{1-[4-({3-[4-({[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl]amino}methyl)-1H-imidazol-1-yl]propyl}carbamoyl)phenyl]-3-(trifluoromethyl)-1H-pyrazol-4-yl}-1,3-oxazole-4-carboxamide

2360533-90-8