ChemicalBook > CAS DataBase List > 1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-

1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-

Product Name
1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-
CAS No.
1807758-81-1
Chemical Name
1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-
Synonyms
SIRT7 inhibitor 97491;SIRT7 inhibitor 97491, 10 mM in DMSO;N1-(5-(4-Chlorophenyl)oxazol-2-yl)benzene-1,3-diamine;1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-;3-N-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine;SIRT7,inhibit,SIRT7 inhibitor 97491,p53 K373/382,Sirtuin,tumor,SIRT-7 inhibitor 97491,deacetylase,Apoptosis,Inhibitor
CBNumber
CB88200837
Molecular Formula
C15H12ClN3O
Formula Weight
285.73
MOL File
1807758-81-1.mol
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1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Property

Boiling point:
489.9±55.0 °C(Predicted)
Density 
1.354±0.06 g/cm3(Predicted)
pka
4.30±0.10(Predicted)
form 
Solid
color 
Off-white to light yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
5mg
Price
$400
Updated
2021/12/16
Axon Medchem
Product number
Axon2968
Product name
SIRT7inhibitor97491
Purity
99%
Packaging
50mg
Price
$522.5
Updated
2021/12/16
ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
10mg
Price
$680
Updated
2021/12/16
ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
50mg
Price
$1900
Updated
2021/12/16
ChemScene
Product number
CS-0116136
Product name
SIRT7inhibitor97491
Purity
98.05%
Packaging
100mg
Price
$2900
Updated
2021/12/16
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1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Chemical Properties,Usage,Production

Uses

SIRT7 inhibitor 97491, a potent SIRT7 inhibitor with an IC50 of 325 nM, reduces deacetylase activity of SIRT7 in a dose-dependent manner. SIRT7 inhibitor 97491 prevents tumor progression by increasing p53 stability through acetylation at K373/382. SIRT7 inhibitor 97491 promotes apoptosis through caspase pathway.[1].

in vivo

SIRT7 inhibitor 97491 (2 mg/kg; intraperitoneally injected; for 3 weeks, except on weekends) inhibits tumor growth in xenograft mice[1].

Animal Model:Balb/c nude mice (18-20 g; 6-8 weeks old) with MES-SA cells[1]
Dosage:2 mg/kg
Administration:Intraperitoneally injected; for 3 weeks, except on weekends.
Result:Inhibited cancer growth in vivo.

IC 50

SIRT7: 325 nM (IC50)

References

[1] Ji-Hye Kim, et al. Identification of a Novel SIRT7 Inhibitor as Anticancer Drug Candidate. Biochem Biophys Res Commun. 2019 Jan 8;508(2):451-457. DOI:10.1016/j.bbrc.2018.11.120

1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]- Suppliers

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1807758-81-1, 1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-Related Search:


  • 1,3-Benzenediamine, N1-[5-(4-chlorophenyl)-2-oxazolyl]-
  • SIRT7 inhibitor 97491
  • N1-(5-(4-Chlorophenyl)oxazol-2-yl)benzene-1,3-diamine
  • SIRT7,inhibit,SIRT7 inhibitor 97491,p53 K373/382,Sirtuin,tumor,SIRT-7 inhibitor 97491,deacetylase,Apoptosis,Inhibitor
  • SIRT7 inhibitor 97491, 10 mM in DMSO
  • 3-N-[5-(4-chlorophenyl)-1,3-oxazol-2-yl]benzene-1,3-diamine
  • 1807758-81-1