((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE
- Product Name
- ((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE
- CAS No.
- 52685-51-5
- Chemical Name
- ((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE
- Synonyms
- 4-Iodobut-3-en-2-yl(trimethyl)silane;((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE;Silane, [(1E)-3-iodo-1-methyl-1-propen-1-yl]trimethyl-
- CBNumber
- CB8850795
- Molecular Formula
- C7H15ISi
- Formula Weight
- 254.18
- MOL File
- 52685-51-5.mol
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Property
- Boiling point:
- 188.9±23.0 °C(Predicted)
- Density
- 1.323±0.06 g/cm3(Predicted)
- solubility
- freely sol organic solvents.
N-Bromosuccinimide Price
- Product number
- ORS0003597
- Product name
- ((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.63
- Updated
- 2021/12/16
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Chemical Properties,Usage,Production
Physical properties
bp 60 °C/20 mmHg.
Uses
(E)-1-Iodo-3-trimethylsilyl-2-butene can be used as annulation reagent; alkylative equivalent of 3-buten-2-one; 3-ketobutyl synthon.
Preparation
the first reported preparation of this reagent lacked full experimental details. The preparation given is a compilation of thework of several groups; the various steps have been selected to give optimum yields. 2-Propyn-1-ol is converted3 into its 3-(trimethylsilyl) derivative (1), which is then reduced4 using sodium bis(2-methoxyethoxy)aluminum hydride (Red-Al). The intermediate vinylaluminum is reacted with iodine to produce the (Z)-iodoalkene (2). Treatment of this with lithium dimethylcuprate gives the allylic alcohol (3);. transformation into (E)-(3-chloro-1-methyl-1-propenyl)trimethylsilane (4) followed by halogen exchange with sodium iodide then gives reagent (5).
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Preparation Products And Raw materials
Raw materials
Preparation Products
((E)-3-IODO-1-METHYLPROPENYL)-TRIMETHYLSILANE Suppliers
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