ChemicalBook > CAS DataBase List > 1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-

1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-

Product Name
1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-
CAS No.
1207660-00-1
Chemical Name
1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-
Synonyms
HIT ID;Indophagolin;Indophagolin, 10 mM in DMSO;5-Bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(cyclopropanecarbonyl)indoline-6-sulfonamide;1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-;inhibit,formation,Inhibitor,Indophagolin,5-hydroxytryptamine Receptor,autophagosome,Serotonin Receptor,P2XRs,P2X Receptor,5-HT Receptor,membrane-bound,indoline-based,class,Autophagy
CBNumber
CB88530848
Molecular Formula
C19H15BrClF3N2O3S
Formula Weight
523.75
MOL File
1207660-00-1.mol
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1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Property

Boiling point:
664.5±65.0 °C(Predicted)
Density 
1.740±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO:250.0(Max Conc. mg/mL);477.33(Max Conc. mM)
pka
6.84±0.20(Predicted)
form 
Solid
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
10mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
25mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
50mg
Price
$1450
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
100mg
Price
$2250
Updated
2021/12/16
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1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Chemical Properties,Usage,Production

Uses

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

IC 50

P2X1: 2.4 μM (IC50); P2X4: 2.71 μM (IC50); P2Y11: 3.4 μM (IC50); P2X3: 3.49 μM (IC50); P2Y4: 4.89 μM (IC50); P2Y6: 15.4 μM (IC50); Autophagy: 140 nM (IC50); 5-HT6 Receptor: 1.0 μM (IC50)

References

[1] Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1. DOI:10.1016/j.chembiol.2021.02.017

1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Suppliers

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1207660-00-1, 1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-Related Search:


  • 1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-
  • HIT ID
  • Indophagolin
  • 5-Bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(cyclopropanecarbonyl)indoline-6-sulfonamide
  • inhibit,formation,Inhibitor,Indophagolin,5-hydroxytryptamine Receptor,autophagosome,Serotonin Receptor,P2XRs,P2X Receptor,5-HT Receptor,membrane-bound,indoline-based,class,Autophagy
  • Indophagolin, 10 mM in DMSO
  • 1207660-00-1
  • C19H15BrClF3N2O3S