ChemicalBook > CAS DataBase List > 1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-

1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-

Product Name
1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-
CAS No.
1207660-00-1
Chemical Name
1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-
Synonyms
HIT ID;Indophagolin;Indophagolin, 10 mM in DMSO;5-Bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(cyclopropanecarbonyl)indoline-6-sulfonamide;1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-;inhibit,formation,Inhibitor,Indophagolin,5-hydroxytryptamine Receptor,autophagosome,Serotonin Receptor,P2XRs,P2X Receptor,5-HT Receptor,membrane-bound,indoline-based,class,Autophagy
CBNumber
CB88530848
Molecular Formula
C19H15BrClF3N2O3S
Formula Weight
523.75
MOL File
1207660-00-1.mol
More
Less

1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Property

Boiling point:
664.5±65.0 °C(Predicted)
Density 
1.740±0.06 g/cm3(Predicted)
storage temp. 
4°C, protect from light
solubility 
DMSO:250.0(Max Conc. mg/mL);477.33(Max Conc. mM)
pka
6.84±0.20(Predicted)
form 
Solid
color 
White to off-white
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More
Less

N-Bromosuccinimide Price

ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
5mg
Price
$300
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
10mg
Price
$480
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
25mg
Price
$950
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
50mg
Price
$1450
Updated
2021/12/16
ChemScene
Product number
CS-0158720
Product name
Indophagolin
Packaging
100mg
Price
$2250
Updated
2021/12/16
More
Less

1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Chemical Properties,Usage,Production

Uses

Indophagolin is a potent, indoline-containing autophagy inhibitor (IC50=140 nM). Indophagolin antagonizes the purinergic receptor P2X4 as well as P2X1 and P2X3 with IC50s of 2.71, 2.40 and 3.49 μM, respectively. Indophagolin also antagonizes the Gq-protein-coupled P2Y4, P2Y6, and P2Y11 receptors (IC50s =3.4~15.4 μM). Indophagolin has a strong antagonistic effect on serotonin receptor 5-HT6 (IC50=1.0 μM) and a moderate effect on receptors 5-HT1B, 5-HT2B, 5-HT4e, and 5-HT7[1].

IC 50

P2X1: 2.4 μM (IC50); P2X4: 2.71 μM (IC50); P2Y11: 3.4 μM (IC50); P2X3: 3.49 μM (IC50); P2Y4: 4.89 μM (IC50); P2Y6: 15.4 μM (IC50); Autophagy: 140 nM (IC50); 5-HT6 Receptor: 1.0 μM (IC50)

References

[1] Carnero Corrales MA, et al. Thermal proteome profiling identifies the membrane-bound purinergic receptor P2X4 as a target of the autophagy inhibitor indophagolin [published online ahead of print, 2021 Mar 9]. Cell Chem Biol. 2021;S2451-9456(21)00102-1. DOI:10.1016/j.chembiol.2021.02.017

1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro- Suppliers

China 29 United States 4 Global 33
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58

1207660-00-1, 1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-Related Search:


  • 1H-Indole-6-sulfonamide, 5-bromo-N-[4-chloro-3-(trifluoromethyl)phenyl]-1-(cyclopropylcarbonyl)-2,3-dihydro-
  • HIT ID
  • Indophagolin
  • 5-Bromo-N-(4-chloro-3-(trifluoromethyl)phenyl)-1-(cyclopropanecarbonyl)indoline-6-sulfonamide
  • inhibit,formation,Inhibitor,Indophagolin,5-hydroxytryptamine Receptor,autophagosome,Serotonin Receptor,P2XRs,P2X Receptor,5-HT Receptor,membrane-bound,indoline-based,class,Autophagy
  • Indophagolin, 10 mM in DMSO
  • 1207660-00-1
  • C19H15BrClF3N2O3S