ChemicalBook > CAS DataBase List > 4-Methylumbelliferyl-beta-D-glucopyranoside

4-Methylumbelliferyl-beta-D-glucopyranoside

Product Name
4-Methylumbelliferyl-beta-D-glucopyranoside
CAS No.
18997-57-4
Chemical Name
4-Methylumbelliferyl-beta-D-glucopyranoside
Synonyms
MUD;MUG;MU-Glu;MUGGAL;MU-GAL;7-(B2;4-MU-GLU;GLC1-B-4MU;MUGLUCOSIDE;4-MU-β-Gluc
CBNumber
CB8853266
Molecular Formula
C16H18O8
Formula Weight
338.31
MOL File
18997-57-4.mol
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4-Methylumbelliferyl-beta-D-glucopyranoside Property

Melting point:
258-263 °C (dec.)
Boiling point:
394.46°C (rough estimate)
Density 
1.522
refractive index 
1.4430 (estimate)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
DMF: 5 mg/ml; DMSO: 50 mg/ml
pka
12.73±0.70(Predicted)
form 
Powder
color 
White to off-white
Water Solubility 
Soluble in DMF or water
λmax
320nm(Buffer)(lit.)
BRN 
94672
InChI
InChI=1/C16H18O8/c1-7-4-12(18)23-10-5-8(2-3-9(7)10)22-16-15(21)14(20)13(19)11(6-17)24-16/h2-5,11,13-17,19-21H,6H2,1H3/t11-,13+,14+,15-,16-/s3
InChIKey
YUDPTGPSBJVHCN-ZDHZLMEDNA-N
SMILES
C12OC(C=C(C)C=1C=CC(O[C@H]1[C@H](O)[C@H]([C@@H](O)[C@@H](CO)O1)O)=C2)=O |&1:11,12,14,15,17,r|
CAS DataBase Reference
18997-57-4(CAS DataBase Reference)
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Safety

Hazard Codes 
T+
Risk Statements 
26/27/28
Safety Statements 
22-24/25
WGK Germany 
3
F 
3-10-21
HS Code 
29389090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
M3633
Product name
4-Methylumbelliferyl β-D-glucopyranoside
Purity
β-glucosidase substrate
Packaging
1g
Price
$467.5
Updated
2025/07/31
Sigma-Aldrich
Product number
M3633
Product name
4-Methylumbelliferyl β-D-glucopyranoside
Purity
β-glucosidase substrate
Packaging
5g
Price
$1930
Updated
2025/07/31
TCI Chemical
Product number
M3022
Product name
4-Methylumbelliferyl β-D-Glucopyranoside
Purity
>98.0%(HPLC)
Packaging
250mg
Price
$26
Updated
2025/07/31
TCI Chemical
Product number
M3022
Product name
4-Methylumbelliferyl β-D-Glucopyranoside
Purity
>98.0%(HPLC)
Packaging
1g
Price
$73
Updated
2025/07/31
Cayman Chemical
Product number
20948
Product name
4-Methylumbelliferyl β-D-Glucopyranoside
Purity
≥98%
Packaging
250mg
Price
$32
Updated
2024/03/01
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4-Methylumbelliferyl-beta-D-glucopyranoside Chemical Properties,Usage,Production

Description

4-Methylumbelliferyl-β-D-Glucopyranoside (4-MUG) is a fluorogenic substrate of β-glucosidase and β-glucocerebrosidase (also known as glucosylceramidase). In addition to its use in characterizing novel β-glucosidases, 4-MUG is used in assays to evaluate deficiency in β- glucocerebrosidase activity related to Gaucher disease. Hydrolysis of 4-MUG releases the fluorescent product 4-MU, which has an emission maximum at 445-454 nm. The excitation maximum for 4-MU is pH-dependent: 330, 370, and 385 nm at pH 4.6, 7.4, and 10.4, respectively.

Chemical Properties

White Powder

Uses

A fluorogenic substrate in the assay of ?-glucosidase. Fluorescence: max. Abs. 316nm; max. Em. 372nm; e x 10-3: 15

Uses

4-Methylumbelliferyl β-D-glucopyranoside has been used as substrate:

  • in glucosylceramidase β enzyme activity assay in lysosome-enriched fractions from primary hippocampal neurons
  • in β-glucosidase assay during yeast fermentation
  • to assay glucocerebrosidase 1 (GBA1)-related glucosidase activity in macrophage cell line (RAW)

Uses

A fluorogenic substrate in the assay of ?-glucosidase.Fluorescence: max. Abs. 316nm; max. Em. 372nm; e x 10-3: 15

Definition

ChEBI: A beta-D-glucoside having a 4-methylumbelliferyl substituent at the anomeric position.

Biochem/physiol Actions

4-Methylumbelliferyl β-D-glucopyranoside is a synthetic enzymatic substrate for glycosidase. It has been used as substrate for the β- glucosidase from enterococci.

Purification Methods

4-Methylumbellifer-7-yl--Dglucopyranoside crystallises as the half hydrate from hot H2O. [Constantzas & Kocourek Collect Czech Chem Commun 24 1099 1959, De Re et al. Ann Chim (Rome) 4 9 2089 1959, Courtin-Duchateau & Veyrière Carbohydr Research 65 23, 29 1978, Beilstein 18 III/IV 5152, 8 IV 433, 18/7 V 616.]

References

[1] ALICIA HERNáNDEZ-GUZMáN. Purification and characterization of an extracellular β-glucosidase from Sporothrix schenckii[J]. FEBS Open Bio, 2016, 6 11: 1067-1077. DOI: 10.1002/2211-5463.12108
[2] RADOS?AW KWAPISZEWSKI. A microfluidic device with fluorimetric detection for intracellular components analysis[J]. Biomedical Microdevices, 2011, 13 3: 431-440. DOI: 10.1007/s10544-011-9511-0
[3] MEERA SHANMUGANATHAN  Philip B M. Inhibitor screening of pharmacological chaperones for lysosomal β-glucocerebrosidase by capillary electrophoresis[J]. Analytical and Bioanalytical Chemistry, 2011, 399 8: 2843-2853. DOI: 10.1007/s00216-011-4671-6

4-Methylumbelliferyl-beta-D-glucopyranoside Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-Methylumbelliferyl-beta-D-glucopyranoside manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
4-Methylumbelliferyl-beta-D-glucopyranoside 18997-57-4
Price
US $0.00/G
Min. Order
10G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-15
Zhuozhou Wenxi import and Export Co., Ltd
Product
4-Methylumbelliferyl-beta-D-glucopyranoside 18997-57-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Career Henan Chemical Co
Product
4-Methylumbelliferyl-beta-D-glucopyranoside 18997-57-4
Price
US $1.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
100KG
Release date
2018-12-18

18997-57-4, 4-Methylumbelliferyl-beta-D-glucopyranosideRelated Search:

4-Methylumbelliferyl-beta-D-glucopyranoside 4-Methylumbelliferyl-beta-D-glucuronide 3,4-DIMETHYLUMBELLIFERONE 6-Hexadecanoylamido-4-methylumbelliferyl-beta-D-galactopyranoside 4-CHLOROMETHYL-6,8-DIFLUOROUMBELLIFERYL-BETA-D-GALACTOPYRANOSIDE 4-Methylumbelliferyl 3,4,6-Tri-O-acetyl-2-O-(2,3,4-tri-O-benzoyl-a-L-fucopyranosyl)-b-D-galactopyranoside 4-(TRIFLUOROMETHYL)UMBELLIFERYL-BETA-D-GALACTOPYRANOSIDE 4-Methylumbelliferylb-D-gentiotrioside 4-Methylumbelliferylbeta-D-galactopyranoside-6-sulfatesodiumsalt 4-METHYLUMBELLIFERYL 3,4,6-TRI-O-ACETYL-B-D-GALACTOPYRANOSIDE 4-Methylumbelliferyl 4,6-O-Benzylidene-b-D-galactopyranoside 4-METHYLUMBELLIFERYL-BETA-D-LACTOSIDE 4-(TRIFLUOROMETHYL)UMBELLIFERYL-BETA-D-GLUCOPYRANOSIDE 4-Methylumbelliferyl 2,3,6-Tri-O-benzoyl-b-D-galactopyranoside 4-TRIFLUOROMETHYL-7-HYDROXYCOUMARIN GLUCURONIDE POTASSIUM SALT 4-Methylumbelliferyl 4-O-(a-L-Fucopyranosyl)-b-D-galactopyranoside 4-METHYLUMBELLIFERYL-BETA-D-CELLOBIOPYRANOSIDE 4-Methylumbelliferyl2-O-(a-L-fucopyranosyl)-b-D-galactopyranoside

  • 4-METHYLUMBELLIFERYL-BETA-D-GLUCO-PYRANOSIDE FOR FLUORESCENCE 99+%
  • 4-METHYLUMBELLIFERYL BETA-D-GLUCOSIDE CRYSTALLINE
  • 4-METHYLUMBELLIFERYL-b-D-GLUCOPYRANOSIDE extrapure
  • 4-methylumberiferryl-beta-D-glucopyranoside
  • 4-Methylumbelliferryl-β-D-glucoside
  • 7-(β-D-Glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
  • 7-(β-D-Glucopyranosyloxy)-4-methylcoumarin
  • 4-Methylumbelliferyl-beta-D-glucopyranoside,99%
  • 4-Methylumbellifery-β-D-glucopyranoside
  • 4-Methylumbelliferyl β-D-glucopyranoside ,98%
  • MU-Glu
  • 3-MethyluMbelliferyl β-D-glucopyranoside
  • 4-MethyluMbelliferyl-beta-D-glucopyranoside, 99% 500MG
  • 4-MethyluMbelliferyl Glucopyranoside
  • 4-Methylumbelliferyl β-D-glucopyranosid
  • 4-Methylumbelliferyl-beta-D-glucoside *CAS 18997-57-4*
  • 4-Methylumbelliferyl β-D-glucopyranoside,MUD
  • 4-Methyl-7-(((2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxyMethyl)tetrahydro-2H-pyran-2-yl)oxy)-2H-chroMen-2-one
  • 4-methyl-7-[[(2S,3R,4S,5S,6R)-3,4,5-trihydroxy-6-(hydroxymethyl)-2-oxanyl]oxy]-1-benzopyran-2-one
  • 4-methylumbelliferylglucoside
  • 7-(beta-d-glucopyranosyloxy)-4-methyl-2h-1-benzopyran-2-on
  • MUD
  • MUGGAL
  • MUGLUCOSIDE
  • MUG
  • MU-GAL
  • MUGALACTOSIDE
  • METHYLUMBELLIFERYL-B-D-GALACTOPYRANOSIDE, 4-
  • METHYLUMBELLIFERYL-B-D-GLUCOPYRANOSIDE, 4-
  • GLC1-B-4MU
  • 4-METHYLUMBELLIFERYL BETA-D-GLUCOSIDE
  • 4-METHYLUMBELLIFERYL B-D-GALACTOPYRANOSIDE
  • 4-METHYLUMBELLIFERYL-B-D-GALACTOSIDE
  • 4-MU-BETA-D-GLC
  • 4-MU-BETA-D-GAL
  • 7-HYDROXY-4-METHYLCUMARIN-BETA-D-GALACTOPYRANOSID
  • 7-HYDROXY-4-METHYLCUMARIN-BETA-D-GLUCOPYRANOSID
  • 4-METHYLUMBELLIFERYL-B-D-GLUCOPYRANOSIDE
  • 4-METHYLUMBELLIFERYL-B-D-GLUCOSIDE
  • 4'-METHYLUMBELLIFERYL-BETA-D-GLUCOPYRANOSIDE
  • 4-METHYLUMBELLIFERYL-BETA-D-GLUCOPYRANOSIDE
  • 3-Methylumbelliferyl
  • 7-(beta-D-glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
  • 4-METHYLUMBELLIFERYL-SS-D-GLUCOPYRANOSIDE
  • 2H-1-Benzopyran-2-one, 7-(β-D-glucopyranosyloxy)-4-methyl-
  • 4-Methylumbelliferyl β-D-glucopyranoside
  • 4-Methylumbelliferyl-beta-D-glucopyranoside USP/EP/BP
  • 4-Methylumbelliferyl β-D-Glucoside
  • 7-(B2
  • -D-glucopyranosyloxy)-4-methyl-2H-1-benzopyran-2-one
  • 4-Methylumbelliferyl-β-D- Glucopyranoside extrapure
  • 2H-1-Benzopyran-2-one,7-(b-D-glucopyranosyloxy)-4-methyl-
  • 4-MU-GLU
  • 4-MU-β-Gluc
  • fluorogenic,substrate,4 Methylumbelliferyl β D Glucopyranoside,Inhibitor,chromogenic,4MethylumbelliferylβDGlucopyranoside,inhibit,4-methylumbelliferyl,fluorescent
  • 4-Methylumbelliferone- β- D-glucoside
  • MU-GLU, Fluorogenic beta-glucosidase substrate
  • 4-Methylumbelliferyl β-<sc>D</sc>-glucopyranoside