ChemicalBook > CAS DataBase List > Ethyl cyanoformate

Ethyl cyanoformate

Product Name
Ethyl cyanoformate
CAS No.
623-49-4
Chemical Name
Ethyl cyanoformate
Synonyms
NSC 65347;C2H5OC(O)CN;cyanoformate;ETHYL CYANOFORMATE;Ethylcyanoformate,99%;ethyl carbonocyanidate;Ethyl cyanoformate 99%;Ethoxycarbonyl Cyanide;Ethyl cyanocarboxylate;Ethyl Cyanoformate >
CBNumber
CB8854001
Molecular Formula
C4H5NO2
Formula Weight
99.09
MOL File
623-49-4.mol
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Ethyl cyanoformate Property

Boiling point:
115-116 °C (lit.)
Density 
1.003 g/mL at 25 °C (lit.)
refractive index 
n20/D 1.381(lit.)
Flash point:
76 °F
storage temp. 
Inert atmosphere,2-8°C
solubility 
Miscible with chloroform and methanol.
form 
Liquid
Specific Gravity
1.01
color 
Clear colorless
Sensitive 
Moisture Sensitive
BRN 
635955
Exposure limits
NIOSH: IDLH 25 mg/m3
CAS DataBase Reference
623-49-4(CAS DataBase Reference)
NIST Chemistry Reference
NCCOOC2H5(623-49-4)
EPA Substance Registry System
Carbonocyanidic acid, ethyl ester (623-49-4)
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Safety

Hazard Codes 
T,F
Risk Statements 
10-23/24/25-34-36/37/38
Safety Statements 
26-36/37/39-45-24/25-16-7/9
RIDADR 
UN 3275 6.1/PG 2
WGK Germany 
3
F 
10-19-21
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
II
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H226Flammable liquid and vapour

H314Causes severe skin burns and eye damage

Precautionary statements

P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
E18859
Product name
Ethyl cyanoformate
Purity
99%
Packaging
10g
Price
$86.5
Updated
2024/03/01
Sigma-Aldrich
Product number
E18859
Product name
Ethyl cyanoformate
Purity
99%
Packaging
50g
Price
$114
Updated
2024/03/01
TCI Chemical
Product number
C1266
Product name
Ethyl Cyanoformate
Purity
>98.0%(GC)
Packaging
5g
Price
$35
Updated
2024/03/01
TCI Chemical
Product number
C1266
Product name
Ethyl Cyanoformate
Purity
>98.0%(GC)
Packaging
25g
Price
$98
Updated
2024/03/01
Alfa Aesar
Product number
L15777
Product name
Ethyl cyanoformate, 99%
Packaging
5g
Price
$39.1
Updated
2024/03/01
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Ethyl cyanoformate Chemical Properties,Usage,Production

Chemical Properties

Clear Colourless Liquid

Uses

Ethyl cyanoformate is used as reagent in the preparation of N-substituted amindinoformic acid and ethyl-4-quinazoline -2-carboxylate.

Uses

Ethyl Cyanoformate (cas# 623-49-4) is a compound useful in organic synthesis.

Uses

Ethyl cyanoformate can be used as a cyanide source for the cyanation of:

  • Activated olefins in the presence of a titanium catalyst.
  • Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
  • Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.

Application

Ethyl cyanoformate can be used as a cyanide source for the cyanation of:
Activated olefins in the presence of a titanium catalyst.
Carbonyl compounds catalyzed by 4-dimethylaminopyridine (DMAP) to yield corresponding cyanohydrin carbonates under metal-free and solvent-free conditions.
Aldehydes and 2,2,2-trifluoroacetophenone catalyzed by N-heterocyclic carbene (NHC) to yield corresponding cyanohydrins ethyl carbonates.
Ethyl cyanoformate is a general cyanating agent. It can be used in the nucleophilic addition of cyanide to carbonyl compounds, oxidative cyanation of tertiary amines and in the synthesis of β-cyano-substituted acrylates from alkynes.

Purification Methods

Dissolve the cyanoformate in Et2O, dry it over Na2SO4, filter, evaporate and distil it [Malachowsky et al. Chem Ber 70 1016 1937, Adickes et al. J Prakt Chem [2] 133 313 1932, Grundmann et al. Justus Liebigs Ann Chem 577 77 1952]. [Beilstein 2 IV 1862.]

Precautions

Moisture sensitive. Keep the container tightly closed in a dry and well-ventilated place. Incompatible with strong acids, strong bases, strong oxidizing agents and strong reducing agents.

Ethyl cyanoformate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl cyanoformate Suppliers

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View Lastest Price from Ethyl cyanoformate manufacturers

Baoji Guokang Bio-Technology Co., Ltd.
Product
Ethyl cyanoformate 623-49-4
Price
US $157.00/ASSAYS
Min. Order
1KG
Purity
99%
Supply Ability
10 tons
Release date
2021-06-07
Honest Joy Holdings Limited
Product
EthylCarbonocyanidate 623-49-4
Price
US $0.00/KG
Min. Order
1KG
Purity
97.6%
Supply Ability
100 tons
Release date
2022-01-14
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl cyanoformate 623-49-4
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

623-49-4, Ethyl cyanoformateRelated Search:

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