2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide

Product Name: 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
CAS No.: 53995-62-3
Chemical Name: 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide
Synonyms: PFI-90;N'-(Pyridin-2-yl)picolinohydrazide;N'-(Pyridin-2-yl)picolinohydrazide;N'-pyridin-2-ylpyridine-2-carbohydrazide;2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide;antitumor,Inhibitor,PFI 90,differentiation,PAX3-FOXO1,demethylase,PFI-90,apoptosis,histone,Histone Demethylase,myogenic,PFI90,inhibit
CBNumber: CB89028245
Molecular Formula: C11H10N4O
Formula Weight: 214.22
MOL File: 53995-62-3.mol

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2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Property

Melting point:: 128-131 °C
Boiling point:: 359.4±17.0 °C(Predicted)
Density: 1.309±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
form: Solid
pka: 10.14±0.23(Predicted)
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Chemical Properties,Usage,Production

Biological Activity

PFI-90 is a selective inhibitor of histone demethylase (KDM3B) that inhibits PAX3-FOXO1 action. PFI-90 induces apoptosis and myogenic differentiation, resulting in the cell death increased. PFI-90 has the potential for the antitumor activity. (patent WO2021101929A1). PFI-90 shows dose response in RH4, RH30, OSA-CL and TC-32 cells, with IC50s of 812, 3200, 1895 and 1113 nM, respectively[1]. PFI-90 (3 μμ; 24 hours) increases apoptosis in RH4 and SCMC cells[1].

References

[1]. KHAN, Javed, et al. Inhibitors of histone demethylases (pfi-63 and pfi-90) for the treatment of cancer and for the inhibition of histone demethylase in cells. WO2021101929A1.

2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide Suppliers

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53995-62-3, 2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazideRelated Search:

2-Pyridinecarboxylic acid, 2-(2-pyridinyl)hydrazide

PFI-90

N'-(Pyridin-2-yl)picolinohydrazide

antitumor,Inhibitor,PFI 90,differentiation,PAX3-FOXO1,demethylase,PFI-90,apoptosis,histone,Histone Demethylase,myogenic,PFI90,inhibit

N'-(Pyridin-2-yl)picolinohydrazide

N'-pyridin-2-ylpyridine-2-carbohydrazide

53995-62-3