4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

Product Name: 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
CAS No.: 2154342-56-8
Chemical Name: 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl
Synonyms: 3-dione HCl;Poma-PEG2-NH2;Pomalidomide 4'-PEG1-amine;Thalidomide-NH-PEG1-NH2 TFA;Thalidomide-NH-PEG1-NH2 HCl;Pomalidomide-PEG1-C2-amine HCl;6-dioxopiperidin-3-yl)isoindoline-1;Thalidomide-NH-PEG1-NH2 hydrochloride;4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2;Pomalidomide 4'-PEG1-amine hydrochloride
CBNumber: CB89402036
Molecular Formula: C17H21ClN4O5
Formula Weight: 396.83
MOL File: 2154342-56-8.mol

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4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Property

storage temp.: 2-8°C
form: Solid
color: Light yellow to yellow

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Hazard and Precautionary Statements (GHS)

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4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Chemical Properties,Usage,Production

Uses

Thalidomide-NH-PEG1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the Thalidomide based cereblon ligand and a linker used in PROTAC technology[1].

Biological Activity

Pomalidomide 4'-PEG1-amine is a functionalized cereblon ligand for PROTAC? research and development; incorporates an E3 ligase ligand plus a PEG1 linker with terminal amine ready for conjugation to a target protein ligand.

IC 50

Cereblon

storage

Store at -20°C

References

[1] Sato T, et al. Cereblon-Based Small-Molecule Compounds to Control Neural Stem Cell Proliferation in Regenerative Medicine.?Front Cell Dev Biol. 2021;9:629326. Published 2021 Mar 11. DOI:10.3389/fcell.2021.629326
[2] Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. DOI:10.7554/eLife.57277

4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Pomalidomide-NH-PEG1-amine hydrochloride 2154342-56-8
Price: US $0.00/g
Min. Order: 1g
Purity: >99.00%
Supply Ability: 1g
Release date: 2024-04-01

2154342-56-8, 4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HClRelated Search:

4-[(2-(2-Aminoethoxy)ethyl)amino]-2-(2,6-dioxopiperidin-3-yl)isoindoline-1,3-dione HCl

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2154342-56-8