O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
- Product Name
- O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
- CAS No.
- 846549-37-9
- Chemical Name
- O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
- Synonyms
- N3-(PEG)7-COOH;azido-peg-acid (n=8);N-(PEG)-COOH (33 atoms);N3-PEG8-NHCOCH2OCH2COOH;Azido-PEG8-NHCOCH2OCH2COOH;N3-PEG8-CH2CH2NHCOCH2OCH2COOH;N3-(PEG)7-COOH (33 ATOMS) 1 G;N-(PEG)-COOH (33 atoms) Novabiochem;2-((Azido-PEG8-carbamoyl)methoxy)acetic acid;-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7
- CBNumber
- CB8972491
- Molecular Formula
- C22H42N4O12
- Formula Weight
- 554.59
- MOL File
- 846549-37-9.mol
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Property
- storage temp.
- Store at +2°C to +8°C.
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C22H42N4O12/c23-26-25-2-4-31-6-8-33-10-12-35-14-16-37-18-17-36-15-13-34-11-9-32-7-5-30-3-1-24-21(27)19-38-20-22(28)29/h1-20H2,(H,24,27)(H,28,29)
- InChIKey
- WWDNBBVPYDZICO-UHFFFAOYSA-N
- SMILES
- C(CNC(=O)COCC(=O)O)OCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 8.51021
- Product name
- N₃-(PEG)₇-COOH (33 atoms)
- Purity
- Novabiochem?
- Packaging
- 1g
- Price
- $717
- Updated
- 2025/07/31
- Product number
- 8.51021
- Product name
- N₃-(PEG)₇-COOH (33 atoms)
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $35860
- Updated
- 2025/07/31
- Product number
- 8.51021
- Product name
- N₃-(PEG)₇-COOH (33 atoms)
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 100 g
- Price
- $35860
- Updated
- 2025/07/31
- Product number
- 8.51021
- Product name
- N₃-(PEG)₇-COOH (33 atoms)
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 250 g
- Price
- $83690
- Updated
- 2025/07/31
- Product number
- 8.51021
- Product name
- N₃-(PEG)₇-COOH (33 atoms)
- Purity
- Novabiochem<SUP>®</SUP>
- Packaging
- 250 g
- Price
- $83690
- Updated
- 2025/07/31
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Chemical Properties,Usage,Production
Description
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG linker containing an azide group with a terminal carboxylic acid. The hydrophilic PEG spacer increases solubility in aqueous media. The azide group can react with alkyne, BCN, DBCO via Click Chemistry to yield a stable triazole linkage. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Uses
2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
reaction suitability
reaction type: click chemistry
reagent type: cross-linking reagent
IC 50
PEGs
References
[1] An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562 DOI:10.1016/j.ebiom.2018.09.005
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Preparation Products And Raw materials
Raw materials
Preparation Products
O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 Suppliers
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View Lastest Price from O-(2-AZIDOETHYL)-O-(2-(DIGLYCOLYL-AMINO)ETHYL)EG-7 manufacturers
- Product
- 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9
- Price
- US $2.00-6.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-08-06
- Product
- 2-((Azido-PEG8-carbamoyl)methoxy)acetic acid 846549-37-9
- Price
- US $720.00/g
- Min. Order
- 1g
- Purity
- 98
- Supply Ability
- 1 Kg
- Release date
- 2024-02-11