Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
- Product Name
- Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
- CAS No.
- 67475-55-2
- Chemical Name
- Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI)
- Synonyms
- 7475-55-2;4-(Chlorosulphonyl)-2-fluoroanisole;Benzenesulfonyl chloride, 3-fluoro-4-methoxy-;3-Fluoro-4-methoxybenzenesulfonyl chloride 97%;Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI);3-fluoro-4-methoxybenzenesulfonyl chloride(SALTDATA: FREE)
- CBNumber
- CB91068567
- Molecular Formula
- C7H6ClFO3S
- Formula Weight
- 224.64
- MOL File
- 67475-55-2.mol
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) Property
- Melting point:
- 77-81 °C
- Boiling point:
- 314.9±22.0 °C(Predicted)
- Density
- 1.455±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- color
- White
- Sensitive
- Moisture Sensitive
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- HazardClass
- IRRITANT
- HazardClass
- 8
- HS Code
- 29049090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 700983
- Product name
- 3-Fluoro-4-methoxybenzenesulfonyl chloride
- Purity
- 97%
- Packaging
- 1g
- Price
- $39.5
- Updated
- 2023/01/07
- Product number
- F600938
- Product name
- 3-Fluoro-4-methoxybenzenesulfonyl chloride
- Packaging
- 5g
- Price
- $265
- Updated
- 2021/12/16
- Product number
- F600938
- Product name
- 3-Fluoro-4-methoxybenzenesulfonyl chloride
- Packaging
- 1g
- Price
- $65
- Updated
- 2021/12/16
- Product number
- PC5547
- Product name
- 3-Fluoro-4-methoxybenzenesulphonylchloride
- Packaging
- 5g
- Price
- $74
- Updated
- 2021/12/16
- Product number
- 020070
- Product name
- 3-Fluoro-4-methoxybenzenesulfonyl chloride
- Purity
- 95+%
- Packaging
- 5g
- Price
- $74
- Updated
- 2021/12/16
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) Chemical Properties,Usage,Production
Synthesis
321-28-8
67475-55-2
The general procedure for the synthesis of 3-fluoro-4-methoxybenzenesulfonyl chloride from 2-fluoroanisole was as follows: 2-fluoroanisole (33.7 mL, 301 mmol) was dissolved in chloroform (250 mL), stirred and cooled to 0 °C. Subsequently, chlorosulfonic acid (50.0 mL, 752 mmol) was slowly added dropwise. After the dropwise addition, the reaction mixture was stirred at room temperature for 14 hours. After completion of the reaction, the mixture was poured into ice water (700 mL) and the aqueous phase was extracted with chloroform (2 x 200 mL). The organic phases were combined, dried with anhydrous sodium sulfate, filtered and concentrated to afford 3-fluoro-4-methoxybenzenesulfonyl chloride as a white fine solid (58.6 g, 87% yield) with a melting point of 80°C. 1H NMR (400 MHz, DMSO-d6) δ: 7.32 (m, 1H), 7.25 (dd, J = 11.5, 2.0 Hz, 1H), 7.05 (t, J = 8.5 Hz, 2.0 Hz, 1H). J = 8.5 Hz, 1H), 3.78 (s, 3H).
References
[1] Patent: WO2004/50631, 2004, A1. Location in patent: Page 122-123
Benzenesulfonyl chloride, 3-fluoro-4-methoxy- (9CI) Preparation Products And Raw materials
Raw materials
Preparation Products
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