PB28dihydrochloride
- Product Name
- PB28dihydrochloride
- CAS No.
- 172906-90-0
- Chemical Name
- PB28dihydrochloride
- Synonyms
- PB-28;PB28 dihydrochloride >=98% (HPLC), solid;Piperazine,1-cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]-;1-Cyclohexyl-4-[3-(1,2,3,4-tetrahydro-5-methoxy-1-naphthalenyl)propyl]piperazinedihydrochloride
- CBNumber
- CB91074562
- Molecular Formula
- C24H38N2O
- Formula Weight
- 370.57
- MOL File
- 172906-90-0.mol
PB28dihydrochloride Property
- Boiling point:
- 501.4±50.0 °C(Predicted)
- Density
- 1.032±0.06 g/cm3(Predicted)
- storage temp.
- Desiccate at +4°C
- solubility
- H2O: ~10mg/mL at 60°C
- pka
- 8.32±0.70(Predicted)
- form
- solid
- color
- white
- Water Solubility
- H2O: ~10mg/mL at60°C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P9246
- Product name
- PB28 dihydrochloride
- Purity
- ≥98% (HPLC), solid
- Packaging
- 5mg
- Price
- $136
- Updated
- 2025/07/31
- Product number
- P215100
- Product name
- PB28
- Packaging
- 2.5mg
- Price
- $215
- Updated
- 2021/12/16
- Product number
- API0004726
- Product name
- PB-28
- Purity
- 95.00%
- Packaging
- 10MG
- Price
- $665.81
- Updated
- 2021/12/16
- Product number
- API0004726
- Product name
- PB-28
- Purity
- 95.00%
- Packaging
- 50MG
- Price
- $1073.29
- Updated
- 2021/12/16
PB28dihydrochloride Chemical Properties,Usage,Production
Uses
PB 28 is a selective σ2 receptor agonist. It is also an antitumor and cytotoxic agent.
Definition
ChEBI: PB28 is a member of the class of tetralins that is tetralin that is substituted by 3-(4-cyclohexylpiperazin-1-yl)propyl and methoxy groups at positions 1 and 5, respectively. It is a sigma 2 (sigma2) receptor agonist (Ki = 0.68 nM) and exhibits antineoplastic and anti SARS-CoV-2 activities. It has a role as an anticoronaviral agent, an antineoplastic agent, an apoptosis inducer and a sigma-2 receptor agonist. It is an aromatic ether, a member of piperazines and a member of tetralins.
Biological Activity
High affinity σ 2 receptor agonist (K i values are 0.8 and 15.2 nM for σ 2 and σ 1 receptors respectively) that displays minimal affinity at other receptors. Inhibits electrically evoked twitch in guinea pig bladder and ileum (EC 50 values are 2.62 and 3.96 μ M respectively). Displays antiproliferative and cytotoxic effects in SK-N-SH neuroblastoma and C6 glioma cells.
in vivo
PB28 (10.7 mg/mL; intraperitoneal injection; daily; for two weeks; C57BL/6 female mice) treatment inhibits tumor growth in Panc02 tumor burden mice. PB28 also conferres a survival advantage for mice[2].
| Animal Model: | C57BL/6 female mice (10 weeks old) injected with Panc02 cells[2] |
| Dosage: | 10.7 mg/mL |
| Administration: | Intraperitoneal injection; daily; for two weeks |
| Result: | Inhibited tumor growth in Panc02 tumor burden mice. |
PB28dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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