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PMPA(NAALADaseinhibitor)

Product Name
PMPA(NAALADaseinhibitor)
CAS No.
173039-10-6
Chemical Name
PMPA(NAALADaseinhibitor)
Synonyms
2-PMPA;CS-2454;NAALADASEINHIBITOR;PMPA(NAALADaseinhibitor);2-PMPA(NAALADaseinhibitor);Pentanedioic acid, 2-(phosphonomethyl)-;2-(Phosphonomethyl)pentane-1,5-dioicacid;2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA);inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA
CBNumber
CB91075110
Molecular Formula
C6H11O7P
Formula Weight
226.12
MOL File
173039-10-6.mol
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PMPA(NAALADaseinhibitor) Property

Boiling point:
538.8±60.0 °C(Predicted)
Density 
1.658±0.06 g/cm3(Predicted)
storage temp. 
room temp
solubility 
Soluble to 100 mM in sterile
form 
powder
pka
2.06±0.10(Predicted)
color 
white to beige
Water Solubility 
Soluble to 100 mM in water
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Safety

RTECS 
SA0454800
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
SML1612
Product name
2-PMPA
Purity
≥98% (HPLC)
Packaging
5MG
Price
$116.85
Updated
2025/07/31
Sigma-Aldrich
Product number
SML1612
Product name
2-PMPA
Purity
≥98% (HPLC)
Packaging
25MG
Price
$478.8
Updated
2025/07/31
Cayman Chemical
Product number
21916
Product name
2-(Phosphonomethyl)-pentanedioic Acid
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
21916
Product name
2-(Phosphonomethyl)-pentanedioic Acid
Purity
≥95%
Packaging
5mg
Price
$100
Updated
2024/03/01
Cayman Chemical
Product number
21916
Product name
2-(Phosphonomethyl)-pentanedioic Acid
Purity
≥95%
Packaging
10mg
Price
$139
Updated
2024/03/01
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PMPA(NAALADaseinhibitor) Chemical Properties,Usage,Production

Uses

2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.

Biological Activity

Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).

Biochem/physiol Actions

2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).

in vivo

Intraperitoneal administration of 100 mg/kg 2-PMPA results in maximum concentration in plasma of 275 μg/mL at 0.25 h. The half-life, area under the curve, apparent clearance, and volume of distribution are 0.64 h, 210 μg×h/mL, 7.93 mL/min/kg, and 0.44 L/kg, respectively[1]. 2-PMPA at 250 mg/kg, in an anesthetized mouse, after an initial rise, produces a rapid decline and a striking attenuation in BOLD signals in gray matter. The signature of 2-PMPA on brain T2* signals in gray matter at both 167 and 250 mg/kg includes a significant initial rise lasting several minutes[3]. 2-PMPA has neuroprotective activity in an animal model of stroke and anti-allodynic activity in CCI model. Administration of 2-PMPA (50mg/kg) produces a mean peak concentration of 2-PMPA of 29.66±8.1 μM. This concentration is about 100,000 fold more than is needed for inhibition of NAAG peptidase, and indicates very good penetration to the brain. Administration of 50 mg/kg 2-PMPA (i.p.) produces a continuously increasing extracellular NAAG concentration, which startes directly after application[4].

storage

Desiccate at RT

PMPA(NAALADaseinhibitor) Preparation Products And Raw materials

Raw materials

Preparation Products

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PMPA(NAALADaseinhibitor) Suppliers

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173039-10-6, PMPA(NAALADaseinhibitor)Related Search:

3-PHOSPHONOPROPIONIC ACID 5-PHOSPHONOPENTANOIC ACID PMPA(NAALADaseinhibitor)

  • PMPA(NAALADaseinhibitor)
  • 2-(Phosphonomethyl)pentane-1,5-dioicacid
  • 2-PMPA
  • CS-2454
  • 2-PMPA(NAALADaseinhibitor)
  • NAALADASEINHIBITOR
  • Pentanedioic acid, 2-(phosphonomethyl)-
  • 2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA)
  • inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA
  • 173039-10-6