ChemicalBook > CAS DataBase List > 3-Bromo-2-fluoroaniline

3-Bromo-2-fluoroaniline

Product Name
3-Bromo-2-fluoroaniline
CAS No.
58534-95-5
Chemical Name
3-Bromo-2-fluoroaniline
Synonyms
3-Bromo-2-fluorobenzenamine;3-Bromo-2-fluoroaniline;3-Brome-2-fluoroaniline;3-Bromo-2-fluorophenylamine;3-Bromo-2-fluoroaniline 99%;BenzenaMine, 3-broMo-2-fluoro-;3-bromo-2-fluoroaniline hydrochloride;3-Bromo-2-fluoroaniline ISO 9001：2015 REACH
CBNumber
CB91107268
Molecular Formula
C6H5BrFN
Formula Weight
190.01
MOL File
Mol file
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3-Bromo-2-fluoroaniline Property

Boiling point:
228℃
Density 
1.694
Flash point:
91℃
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
2.13±0.10(Predicted)
form 
liquid
color 
Clear, light yellow
InChI
InChI=1S/C6H5BrFN/c7-4-2-1-3-5(9)6(4)8/h1-3H,9H2
InChIKey
HYPQOSVTIONWSN-UHFFFAOYSA-N
SMILES
C1(N)=CC=CC(Br)=C1F
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Safety

Safety Statements 
24/25
RIDADR 
UN2941
HazardClass 
6.1
HS Code 
29214300
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
CDS023142
Product name
3-Bromo-2-fluoroaniline
Packaging
10 mg
Price
$36.7
Updated
2025/07/31
TRC
Product number
B700283
Product name
3-Bromo-2-fluoroaniline
Packaging
1g
Price
$100
Updated
2021/12/16
TRC
Product number
B700283
Product name
3-Bromo-2-fluoroaniline
Packaging
5g
Price
$150
Updated
2021/12/16
Apolloscientific
Product number
PC8089
Product name
3-Bromo-2-fluoroaniline
Purity
98%
Packaging
25g
Price
$153
Updated
2021/12/16
Oakwood
Product number
077980
Product name
3-Bromo-2-fluoroaniline
Purity
99%
Packaging
25g
Price
$195
Updated
2021/12/16
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3-Bromo-2-fluoroaniline Chemical Properties,Usage,Production

Description

3-Bromo-2-fluoroaniline is an aniline derivative with reactive groups (fluorine and bromine atoms). It is widely used in organic synthesis and can be used as a starting material for the synthesis of KRASG12C inhibitors, which have antitumour activity and can be used in the development of anticancer drugs.

Uses

3-Bromo-2-fluoroaniline is used in the preparation of heterotricyclic carboxamides as RIG-1 agonists for treatment cell proliferation disorders.

Synthesis

58534-94-4

58534-95-5

General procedure for the synthesis of 3-bromo-2-fluoroaniline from 2-fluoro-3-bromonitrobenzene: To a mixed solution of 1-bromo-2-fluoro-3-nitrobenzene (13.75 g, 62.76 mmol), acetic acid (26.36 g, 439 mmol), ethanol (150 mL), and water (60 mL) was added, in portions, at room temperature, powdered iron (9.14 g, 163 mmol). The reaction mixture was stirred for 16 h at room temperature and subsequently neutralized with 5N sodium hydroxide solution. The neutralized mixture was extracted with ethyl acetate and the organic layer was sequentially washed with saturated brine, dried over anhydrous sodium sulfate and finally concentrated under reduced pressure. The residue was purified by silica gel fast column chromatography (petroleum ether/ethyl acetate=10:1) to afford the target product 3-bromo-2-fluoroaniline (7.77 g, 65% yield) as a brown oil.

References

[1] Patent: US2011/34450, 2011, A1. Location in patent: Page/Page column 95
[2] Patent: WO2017/15562, 2017, A1. Location in patent: Page/Page column 93-94
[3] Patent: WO2017/87528, 2017, A1. Location in patent: Page/Page column 180; 181
[4] Patent: WO2017/58915, 2017, A1. Location in patent: Page/Page column 102
[5] Patent: US2018/15087, 2018, A1. Location in patent: Paragraph 0318

3-Bromo-2-fluoroaniline Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Bromo-2-fluoroaniline manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
Product
3-Bromo-2-fluoroaniline 58534-95-5
Price
US $2.00-6.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
100kg
Release date
2025-08-06
Shaanxi Dideu New Materials Co. Ltd
Product
3-Bromo-2-fluoroaniline 58534-95-5
Price
US $0.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
10000KGS
Release date
2025-04-29
Hebei Chuanghai Biotechnology Co., Ltd
Product
3-Bromo-2-fluoroaniline 58534-95-5
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-11-01

58534-95-5, 3-Bromo-2-fluoroanilineRelated Search:

4'-Bromoacetanilide 2-Bromoaniline 2,4,6-Tribromoaniline 2-Bromo-5-fluorobenzyl alcohol 2-(Trifluoromethoxy)benzyl bromide 2-BROMO-4-FLUOROBENZYL ALCOHOL 3-Bromo-2-fluoro-phenol Methyl 2-amino-4-bromobenzoate 2-Bromo-5-fluorobenzyl bromide (3-bromo-2-fluorophenyl)methanol 4-Bromo-2-chlorobenzoic acid 3-Bromo-5-nitrobenzoic acid 4-BROMO-3-CHLOROBENZOIC ACID 4-Bromo-2-nitrobenzoic acid 5-AMINO-2-BROMOBENZOIC ACID 3,5-DIBROMO-2-METHOXYBENZOIC ACID

  • 3-Bromo-2-fluoroaniline
  • 3-bromo-2-fluoroaniline hydrochloride
  • 3-Bromo-2-fluoroaniline 99%
  • 3-Bromo-2-fluorophenylamine
  • BenzenaMine, 3-broMo-2-fluoro-
  • 3-Brome-2-fluoroaniline
  • 3-Bromo-2-fluorobenzenamine
  • 3-Bromo-2-fluoroaniline ISO 9001：2015 REACH
  • 58534-95-5
  • 5834-95-5