ChemicalBook > CAS DataBase List > 3-Fluoro-5-bromobenzyl bromide

3-Fluoro-5-bromobenzyl bromide

Product Name: 3-Fluoro-5-bromobenzyl bromide
CAS No.: 216755-57-6
Chemical Name: 3-Fluoro-5-bromobenzyl bromide
Synonyms: 3-Fluoro-5-bromoben bromide;3-Fluoro-5-broMobenl broMide;5-bromo-3-fluorobenzyl bromide;3-Fluoro-5-bromobenzyl bromide;3-Bromo-5-fluorobenzylbromide,95%;3-Fluoride-5-Bromine Bromine Benzyl;1-Bromo-3-(bromomethyl)-5-fluorobenzene;Benzene, 1-bromo-3-(bromomethyl)-5-fluoro-;1-Bromo-3-(bromomethyl)-5-fluorobenzene, alpha,3-Dibromo-5-fluorotoluene
CBNumber: CB91139478
Molecular Formula: C7H5Br2F
Formula Weight: 267.92
MOL File: 216755-57-6.mol

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3-Fluoro-5-bromobenzyl bromide Property

Melting point:: 47 °C
Boiling point:: 251℃
Density: 1.923
Flash point:: 106℃
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
solubility: soluble in Methanol
form: powder to crystal
color: White to Almost white
Water Solubility: Slightly soluble in water (2.9 g/L) (25°C).
Sensitive: Lachrymatory

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Safety

Hazard Codes: C,T
Risk Statements: 25
Safety Statements: 45
RIDADR: UN3261
HazardClass: 8
HS Code: 2916399090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

H318Causes serious eye damage

Precautionary statements

P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: B5338
Product name: 3-Bromo-5-fluorobenzyl Bromide
Packaging: 5G
Price: $90
Updated: 2025/07/31

TCI Chemical

Product number: B5338
Product name: 3-Bromo-5-fluorobenzyl Bromide
Packaging: 25G
Price: $314
Updated: 2025/07/31

TRC

Product number: B961523
Product name: 3-Bromo-5-fluorobenzyl Bromide
Packaging: 10g
Price: $285
Updated: 2021/12/16

AK Scientific

Product number: 1020AB
Product name: 3-Bromo-5-fluorobenzyl Bromide
Packaging: 25g
Price: $289
Updated: 2021/12/16

Apolloscientific

Product number: PC9276
Product name: 3-Bromo-5-fluorobenzyl Bromide
Purity: 98%
Packaging: 5g
Price: $86
Updated: 2021/12/16

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3-Fluoro-5-bromobenzyl bromide Chemical Properties,Usage,Production

Uses

3-Bromo-5-fluorobenzyl bromide is employed as a intermediate for pharmaceutical and chemical research.

Synthesis

216755-56-5

216755-57-6

General procedure for the synthesis of 3-fluoro-5-bromobenzyl bromide from (3-bromo-5-fluorophenyl)methanol: 3-bromo-5-fluorobenzyl alcohol (1.79 g, 8.39 mmol) and triphenylphosphine (3.65 g, 10.10 mmol) were dissolved in dichloromethane (45 mL), followed by addition of carbon tetrabromide (3.34 g, 10.10 mmol). The reaction mixture was stirred at room temperature overnight. After completion of the reaction, the solvent was removed by vacuum evaporation. The residue was treated with diethyl ether (50 mL) and stirred at room temperature to form a white slurry. The slurry was filtered through CeliteTM and the residue was washed with diethyl ether (2 x 50 mL). The filtrate and washings were combined and the crude product was obtained by vacuum evaporation. The crude product was purified by silica gel column chromatography using 2% ethyl acetate/hexane as eluent to afford 3-bromo-5-fluorobenzyl bromide (2.21 g, 98%). The structure of the product was confirmed by 1H NMR, 19F NMR and 13C NMR.1H NMR (400 MHz, CDCl3): δ 7.33 (s, 1H), 7.18 (ddd, JHF 8.2 Hz, JHH = 2.0,2.0 Hz, 1H), 7.05 (ddd, JHF = 9.0 Hz, JHH = 1.8,1.6 Hz. 1H), 4.38 (s, 2H); 19F NMR (377 MHz, CDCl3): δ -110.19 to -110.14 (m, 1F); 13C NMR (101 MHz, CDCl3): δ 162.67 (d, JCF = 252.1 Hz), 141.61 (d, JCF = 8.5 Hz), 128.17 ( d, JCF = 3.1 Hz), 122.94 (d, JCF = 10.0 Hz), 119.39 (d, JCF = 24.6 Hz), 115.34 (d, JCF = 22.3 Hz), 31.31 (d, JCF = 2.3 Hz).

References

[1] Patent: WO2016/54728, 2016, A1. Location in patent: Paragraph 00128
[2] Patent: WO2016/74068, 2016, A1. Location in patent: Paragraph 00122
[3] Patent: CN104447730, 2017, B. Location in patent: Paragraph 0149-0150
[4] Patent: US2007/249607, 2007, A1. Location in patent: Page/Page column 81
[5] Patent: US2002/49204, 2002, A1

3-Fluoro-5-bromobenzyl bromide Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 3-Fluoro-5-bromobenzyl bromide manufacturers

Shaanxi Dideu Medichem Co. Ltd

Product: 3-Fluoro-5-bromobenzyl bromide 216755-57-6
Price: US $0.00-0.00/KG
Min. Order: 10mg
Purity: 99%
Supply Ability: 2000tons
Release date: 2020-01-16

Hangzhou ICH Biofarm Co., Ltd

Product: 3-Fluoro-5-bromobenzyl bromide 216755-57-6
Price: US $0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 2000kg
Release date: 2023-06-09

Career Henan Chemical Co

Product: 3-Fluoro-5-bromobenzyl bromide 216755-57-6
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 100KG
Release date: 2019-12-31

216755-57-6, 3-Fluoro-5-bromobenzyl bromideRelated Search:

2-Bromo-1-(bromomethyl)-4-fluorobenzene 3-BROMO-4-FLUOROBENZYL BROMIDE 2-Bromo-5-fluorobenzyl bromide 2-Chloro-4-fluorobenzyl bromide 2-Fluoro-6-bromobenzyl bromide 2-Fluoro-5-bromobenzyl bromide 2-Fluoro-4-chlorobenzyl bromide 3-CHLORO-4-FLUOROBENZYL BROMIDE 2-Chloro-5-fluorobenzyl bromide 3-Fluoro-4-bromobenzyl bromide 4-Bromo-2-fluorobenzyl bromide 2-Bromo-1-(bromomethyl)-3-fluorobenzene 5-BROMO-2,3-DIFLUOROBENZYL BROMIDE TETRABROMO-4-FLUORO-O-XYLENE 3-Fluoro-5-bromobenzyl bromide

3-Fluoro-5-bromobenzyl bromide

1-Bromo-3-(bromomethyl)-5-fluorobenzene

5-bromo-3-fluorobenzyl bromide

1-Bromo-3-(bromomethyl)-5-fluorobenzene, alpha,3-Dibromo-5-fluorotoluene

3-Fluoro-5-bromoben bromide

3-Fluoro-5-broMobenl broMide

3-Fluoride-5-Bromine Bromine Benzyl

Benzene, 1-bromo-3-(bromomethyl)-5-fluoro-

3-Bromo-5-fluorobenzylbromide,95%

216755-57-6

alkyl bromide| alkyl Fluorine

Fluorine series