CI 934

Product Name: CI 934
CAS No.: 91188-00-0
Chemical Name: CI 934
Synonyms: CI 934;PD-114843;Aids007688;Aids-007688;Quinolone cl-934;Merafloxacin (CI-934);Merafloxacin, 10 mM in DMSO;1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;3-Quinolinecarboxylic acid, 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-
CBNumber: CB91398664
Molecular Formula: C19H23F2N3O3
Formula Weight: 379.4
MOL File: 91188-00-0.mol

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CI 934 Property

Melting point:: 200-220.45 °C
Boiling point:: 545.8±50.0 °C(Predicted)
Density: 1.304±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 11.11 mg/mL (29.28 mM; ultrasonic and adjust pH to 3 with HCl)
form: Solid
pka: 6.44±0.50(Predicted)
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Adipogen Life Sciences

Product number: AG-CR1-3756-M005
Product name: Merafloxacin
Purity: ≥95%
Packaging: 5mg
Price: $80
Updated: 2021/12/16

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CI 934 Chemical Properties,Usage,Production

Uses

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2].

Biological Activity

Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2]. Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC50s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively[1].

References

[1]. Sun Y, et, al. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv. 2020 Oct 21;2020.10.21.349225. [2]. Mandell W, et, al. In vitro activity of CI-934, a new quinolone, compared with that of other quinolones and other antimicrobial agents. Antimicrob Agents Chemother. 1986 May;29(5):852-7.

CI 934 Preparation Products And Raw materials

Raw materials

Preparation Products

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CI 934 Suppliers

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91188-00-0, CI 934Related Search:

CI 934

1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

PD-114843

Aids007688

Aids-007688

Quinolone cl-934

3-Quinolinecarboxylic acid, 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-

Merafloxacin (CI-934)

Merafloxacin,frameshifting,SARS-CoV,bacteria,antibacterial,fluoroquinolone,Inhibitor,CI934,gram-positive,inhibit,programmed,coronaviruses,ribosomal,PRF,gram-negative,SARS coronavirus,CI-934

1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid

Merafloxacin, 10 mM in DMSO

91188-00-0