CI 934
- Product Name
- CI 934
- CAS No.
- 91188-00-0
- Chemical Name
- CI 934
- Synonyms
- CI 934;PD-114843;Aids007688;Aids-007688;Quinolone cl-934;Merafloxacin (CI-934);Merafloxacin, 10 mM in DMSO;1-Ethyl-7-(3-((ethylamino)methyl)pyrrolidin-1-yl)-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid;1-Ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid;3-Quinolinecarboxylic acid, 1-ethyl-7-[3-[(ethylamino)methyl]-1-pyrrolidinyl]-6,8-difluoro-1,4-dihydro-4-oxo-
- CBNumber
- CB91398664
- Molecular Formula
- C19H23F2N3O3
- Formula Weight
- 379.4
- MOL File
- 91188-00-0.mol
CI 934 Property
- Melting point:
- 200-220.45 °C
- Boiling point:
- 545.8±50.0 °C(Predicted)
- Density
- 1.304±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO : 11.11 mg/mL (29.28 mM; ultrasonic and adjust pH to 3 with HCl)
- form
- Solid
- pka
- 6.44±0.50(Predicted)
- color
- White to off-white
N-Bromosuccinimide Price
- Product number
- AG-CR1-3756-M005
- Product name
- Merafloxacin
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $80
- Updated
- 2021/12/16
CI 934 Chemical Properties,Usage,Production
Uses
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2].
Biological Activity
Merafloxacin (CI-934), a fluoroquinolone antibacterial agent, is a selective programmed -1 ribosomal frameshifting (-1 PRF) inhibitor of beta coronaviruses. Merafloxacin exhibits in vitro activity against gram-positive and gram-negative bacteria[1][2]. Merafloxacin (5-80 μM) dose-dependently inhibits programmed -1 ribosomal frameshifting (-1 PRF) of SARS-CoV-2, SARS-CoV, hCoVO-C43, and hCoV-HKU1, with IC50s of 19.6 μM, 19.5 μM, 29.7 μM, and 38.6 μM, respectively[1].
References
[1]. Sun Y, et, al. Restriction of SARS-CoV-2 Replication by Targeting Programmed -1 Ribosomal Frameshifting In Vitro. bioRxiv. 2020 Oct 21;2020.10.21.349225. [2]. Mandell W, et, al. In vitro activity of CI-934, a new quinolone, compared with that of other quinolones and other antimicrobial agents. Antimicrob Agents Chemother. 1986 May;29(5):852-7.
CI 934 Preparation Products And Raw materials
Raw materials
Preparation Products
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