dehydrobruceine B
- Product Name
- dehydrobruceine B
- CAS No.
- 53730-90-8
- Chemical Name
- dehydrobruceine B
- Synonyms
- dehydrobruceine B;15β-Acetoxy-13,20-epoxy-2,11β,12α-trihydroxy-3,16-dioxopicrasa-1,4-dien-21-oic acid methyl ester;Picrasa-1,4-dien-21-oic acid, 15-(acetyloxy)-13,20-epoxy-2,11,12-trihydroxy-3,16-dioxo-, methyl ester, (11β,12α,15β)-
- CBNumber
- CB91483180
- Molecular Formula
- C23H26O11
- Formula Weight
- 478.45
- MOL File
- 53730-90-8.mol
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dehydrobruceine B Property
- Boiling point:
- 721.0±60.0 °C(Predicted)
- Density
- 1.55±0.1 g/cm3(Predicted)
- pka
- 7.92±0.70(Predicted)
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dehydrobruceine B Chemical Properties,Usage,Production
Uses
Dehydrobruceine B, a quassinoid, can be isolated from Brucea javanica. Dehydrobruceine B shows a synergistic effect with Cisplatin (HY-17394) to induce apoptosis via mitochondrial method. Dehydrobruceine B increases apoptosis-inducing factor (AIF) and Bax expression and suppresses Keap1-Nrf2[1].
IC 50
Bax; Bcl-xL; Bcl-2
References
[1] Huang Z, et al. Dehydrobruceine B enhances the cisplatin-induced cytotoxicity through regulation of the mitochondrial apoptotic pathway in lung cancer A549 cells. Biomed Pharmacother. 2017 May;89:623-631. DOI:10.1016/j.biopha.2017.02.055
dehydrobruceine B Preparation Products And Raw materials
Raw materials
Preparation Products
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