Salinomycin

Product Name: Salinomycin
CAS No.: 53003-10-4
Chemical Name: Salinomycin
Synonyms: SALINOMYCIN SODIUM;coxistac;Procoxacin;Salinomycin;Salinomycin;SALINOMYCIN 90%;Antibiotic-61477;Salinomycin, >98%;SALINOMYCIN GRANULE;SalinoMycin 12% 24%
CBNumber: CB9161784
Molecular Formula: C42H70O11
Formula Weight: 751
MOL File: 53003-10-4.mol

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Salinomycin Property

Melting point:: 112.5-113.5 °C(lit.)
Boiling point:: 839.2±65.0 °C(Predicted)
alpha: D25 -63° (c = 1 in ethanol)
Density: 1.18±0.1 g/cm3(Predicted)
Flash point:: >110°(230°F)
storage temp.: Sealed in dry,2-8°C
solubility: insoluble in H2O; ≥142.2 mg/mL in EtOH; ≥91.8 mg/mL in DMSO
form: White solid
pka: 6.4 (DMF)
color: White to light yellow
biological source: Streptomyces albus
optical activity: -6325 (cl, ethanol)
Water Solubility: Soluble in methanol. Insoluble in water
Merck: 13,8415
Stability:: Stable, but may be heat sensitive - keep cool. Incompatible with strong oxidizing agents.
LogP: 5.596 (est)
CAS DataBase Reference: 53003-10-4(CAS DataBase Reference)

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Safety

Hazard Codes: T,Xi
Risk Statements: 25-36/37/38
Safety Statements: 45-36-26
RIDADR: UN 3462 6.1/PG 2
WGK Germany: 3
RTECS: VO8620000
F: 10
HazardClass: 6.1(a)
PackingGroup: II
Hazardous Substances Data: 53003-10-4(Hazardous Substances Data)
Toxicity: LD50 in mice (mg/kg): 18 i.p.; 50 orally (Miyazaki)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H300Fatal if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: S4526
Product name: Salinomycin
Purity: from Streptomyces albus, ≥98% (HPLC)
Packaging: 5mg
Price: $243
Updated: 2025/07/31

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 5mg
Price: $25
Updated: 2024/03/01

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 10mg
Price: $37
Updated: 2024/03/01

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 50mg
Price: $94
Updated: 2024/03/01

Cayman Chemical

Product number: 13579
Product name: Salinomycin
Purity: ≥90%
Packaging: 100mg
Price: $163
Updated: 2024/03/01

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Salinomycin Chemical Properties,Usage,Production

Description

Salinomycin was found in the culture mycelium of Streptomyces albus by Otake et al. of the University of Tokyo in 1973. Like other polyether ionophore antibiotics, it shows activity against gram-positive bacteria, fungi, and Coccidium. Salinomycin has been used as a feed additive to protect poultry against coccidial infections.

Chemical Properties

solid

Uses

antibacterial

Uses

Salinomycin is a polyether ionophore with broad spectrum Gram positive and anti-coccidial activity. Salinomycin has a high affinity for monovalent cations, particularly potassium. Salinomycin is used to control coccidia in animals and for growth promotion in ruminants. Recently, salinomycin has been shown to inhibit cancer stem cells and is >100 times more potent than taxol. While the mechanism of action is unknown, it was noted that among the 60,000 compounds screened, another monovalent ionophore, nigericin, and a chloride channel inhibitor, avermectin, were also active.

Uses

Salinomycin was used as a standard in the development of LC-MS/MS method for detection of residual coccidiostats in egg and muscle samples. It was used to screen out CD44⁺CD24^- mesenchymal-like subpopulation within breast carcinomas.

Definition

ChEBI: Salinomycin is a polyketide and a spiroketal. It has a role as an animal growth promotant and a potassium ionophore.

General Description

Chemical structure: polyether

Biological Activity

salinomycin (sal), which is a polyether ionophore antibiotic from streptomyces albus, has been proven to be able to kill different types of human cancer cells, most likely via interfering with abc drug transporters, the wnt/β-catenin signaling pathway, or other pathways.

Biochem/physiol Actions

Salinomycin produced by Streptomyces albus is a carboxylic polyether ionophore with antibiotic and anti-cancer properties. It induces cell death in some types of cancer cells such as breast, lung, gastric cancer, leukemia and osteosarcoma. Salinomycin inhibits multidrug resistance protein 1 and induces apoptosis by the generation of reactive oxygen species that cause DNA damage and inactivation of Stat3. Use of salinomycin as antibiotic results in lowered spermatozoa count and motility and decreased steroidogenesis in mice.

in vitro

several hepatocellular carcinoma (hcc) cell lines were treated with sal. results showed that sal inhibited proliferation and decreased pcna levels. cell cycle analysis showed that sal caused cell cycle arrest in different phases. sal induced apoptosis as characterized by an increase in the bax/bcl-2 ratio. compared to control, β-catenin expression was down-regulated by sal treatment significantly. the ca2+ concentration in hcc cells was examined by flow cytometry and it was found that higher ca2+ concentrations were observed in sal treatment groups [1].

in vivo

the in vivo anti-tumor effect of sal was verified using the hepatoma orthotopic tumor model and results showed that the liver tumor size in sal-treated groups decreased. immunohistochemistry and tunel staining also demonstrated that sal could in vivo inhibit proliferation and induced apoptosis [1].

IC 50

7.7, 13.7 and 10.4 μm for hepg2, smmc-7721 and bel-7402 cell line, respectively (after 24h treatment)

References

[1] JOHANNES KLOSE. Salinomycin: Anti-tumor activity in a pre-clinical colorectal cancer model.[J]. PLoS ONE, 2019: e0211916. DOI:10.1371/journal.pone.0211916.
[2] DESHENG LU. Salinomycin inhibits Wnt signaling and selectively induces apoptosis in chronic lymphocytic leukemia cells.[J]. Proceedings of the National Academy of Sciences of the United States of America, 2011: 13253-13257. DOI:10.1073/pnas.1110431108.
[3] LONGQIN WANG . Self-assembly driven nano-salinomycin for high-efficiency cancer immunotherapy by reticulum stress mediated stemness suppression[J]. Biomaterials, 2025, 325: Article 123632. DOI:10.1016/j.biomaterials.2025.123632.
[4] FAN WANG. Salinomycin inhibits proliferation and induces apoptosis of human hepatocellular carcinoma cells in vitro and in vivo.[J]. PLoS ONE, 2012: e50638. DOI:10.1371/journal.pone.0050638.

Salinomycin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Salinomycin manufacturers

Wuhan JiyunZen Tech Co., Ltd.

Product: Salinomycin 53003-10-4
Price: US $5.00-0.50/KG
Min. Order: 1KG
Purity: 99% hplc
Supply Ability: 500TONS
Release date: 2025-05-08

Hebei Zhuanglai Chemical Trading Co Ltd

Product: Salinomycin 53003-10-4
Price: US $150.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 500kg
Release date: 2024-11-27

Shaanxi TNJONE Pharmaceutical Co., Ltd

Product: Salinomycin 53003-10-4
Price: US $0.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20tons
Release date: 2024-03-28

53003-10-4, SalinomycinRelated Search:

Ethyl cyanoacetate Ethanol Trinexapac-ethyl Ethyl acetate CHLOROPHOSPHONAZO III Ethyl acrylate ISOXADIFEN-ETHYL Ethylparaben Ethyl propiolate Corydaline Sancycline Salicylanilide Bengenin Sodium stearate 3-ETHYL-4-OCTANONE cis-9-Tricosene CIS-3-NONEN-1-OL Salinomycin, 4-methyl-, (4S)-

SALINOMYCIN SODIUM

coxistac

SALINOMYCIN GRANULE

Salinomycin Premix 12%

SALINOMYCIN FROM STREPTOMYCES ALBUS

SALINOMYCIN 90%

SV sodium salt,2,5 salinomycin hydrate

(2R)-2-((5S)-6-{5-[(10S,12R)-2-((6S,5R)-5-Ethyl-5-hydroxy-6-methylperhydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.5.3]pentadec-13-en-9-yl](1S,2S,3S,5R)-2-hydroxy-1,3-dimethyl-4-oxoheptyl}-5-methylperhydro-2H-pyran-2-yl)butanoic acid

Salinomycin

Antibiotic-61477

SalinoMycin(Procoxacin)

SalinoMycin 12% 24%

Procoxacin

Eustin, AHR 3096, K 364, 61477

Salinomycin Solution, 100ppm

Salinomycin, >98%

Salinomycin USP/EP/BP

SALINOMYCIN SODIUM PREMIX （10%, 12%, 45%）

99% purity Salinomycin

Salinomycin (10mM in DMSO)

(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methyltetrahydro-2H-pyran-2-yl)butanoic acid

(R)-2-((2R,5S,6R)-6-((2S,3S,4S,6R)-6-((2S,5S,7R,9S,10S,12R,15R)-2-((2R,5R,6S)-5-Ethyl-5-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)-15-hydroxy-2,10,12-trimethyl-1,6,8-trioxadispiro[4.1.57.35]pentadec-13-en-9-yl)-3-hydroxy-4-methyl-5-oxooctan-2-yl)-5-methylt

SalinomycinQ: What is Salinomycin Q: What is the CAS Number of Salinomycin Q: What is the storage condition of Salinomycin Q: What are the applications of Salinomycin

Salinomycin in Methanol

Salinomycin in Acetonitrile

Salinomycin

53003-10-4

C42H69NaO11

C42H69O11Na

C42H70O11

Antibiotics N-S

Antibiotics A to Z

Antibiotics

BioChemical

KOKCISAN

Antibacterial

Antibiotics

Antibiotics A to

Antibiotics N-SAntibiotics

Chemical Structure Class

L - ZAntibiotics

Mechanism of Action

Monovalent Ion Channels

Polyethers

Inhibitors

Interferes with Cell Membrane Permeability (Ionophores)Voltage-gated Ion Channels

IonophoresSpectrum of Activity

53003-10-4