Fmoc-Lys(Ddiv)-OH
- Product Name
- Fmoc-Lys(Ddiv)-OH
- CAS No.
- 204777-78-6
- Chemical Name
- Fmoc-Lys(Ddiv)-OH
- Synonyms
- Fmoc-Lys(Ddiv)-OH;Fmoc-Lys(ivDde)-0H;FMOC-LYS(IVDDE)-OH;Fmoc-Lys(iVDdde)-OH;FMOC-L-LYS(IVDDE)-OH;FMOC-LYSINE(IVDDE)-OH;FMOC-LYS(IVDDE)-OH 5 G;FMoc-Lys(Ddiv)-OHFMoc-Ly;FMOC-LYS(IVDDE)-OH USP/EP/BP;Fmoc-Lys(ivDde)-OH Novabiochem
- CBNumber
- CB9168561
- Molecular Formula
- C34H42N2O6
- Formula Weight
- 574.71
- MOL File
- 204777-78-6.mol
Fmoc-Lys(Ddiv)-OH Property
- Boiling point:
- 765.6±60.0 °C(Predicted)
- Density
- 1.183±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Soluble in Chloroform,Dichloromethane,Ethyl Acetate,DMSO,Acetone,etc.
- pka
- 3.88±0.21(Predicted)
- form
- Powder
- color
- White
- InChIKey
- PYCBVLUBTMHNPW-MHZLTWQESA-N
- SMILES
- C(O)(=O)[C@H](CCCCN/C(=C1/C(=O)CC(C)(C)CC/1=O)/CC(C)C)NC(OCC1C2=C(C=CC=C2)C2=C1C=CC=C2)=O
Safety
- WGK Germany
- 3
- F
- 10-21
- HS Code
- 2924 29 70
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 8.52082
- Product name
- Fmoc-Lys(ivDde)-OH
- Purity
- Novabiochem?
- Packaging
- 1g
- Price
- $225
- Updated
- 2024/03/01
- Product number
- 8.52082
- Product name
- Fmoc-Lys(ivDde)-OH
- Purity
- Novabiochem?
- Packaging
- 5G
- Price
- $899
- Updated
- 2024/03/01
- Product number
- 29207
- Product name
- Fmoc-Lys(Ddiv)-OH
- Purity
- ≥96.0% (HPLC)
- Packaging
- 1g
- Price
- $446
- Updated
- 2024/03/01
- Product number
- H66820
- Product name
- Nalpha-Fmoc-Nepsilon-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-L-lysine, 95%
- Packaging
- 1g
- Price
- $181.65
- Updated
- 2024/03/01
- Product number
- H66820
- Product name
- Nalpha-Fmoc-Nepsilon-[1-(4,4-dimethyl-2,6-dioxocyclohexylidene)-3-methylbutyl]-L-lysine, 95%
- Packaging
- 250mg
- Price
- $67.7
- Updated
- 2023/06/20
Fmoc-Lys(Ddiv)-OH Chemical Properties,Usage,Production
Description
Fmoc-lys(IVDDE)-OH is a kind of FMOC (9H-fluoren-9-ylmethoxycarbon) and N-IVDDE (1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl) double protected amino acid (lysine). It is important during peptide manufacturing. It is mainly used for the production of peptides which required to be modified on the Lysine side chain, including peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys side chain. It can also be used for the manufacturing of anionic cell penetrating peptide which is useful for intracellular delivery of therapeutic agents such as proteins and nucleic acids. The IVDDE group can be conveniently removed thorough hydrazine in the presence of acid labile groups.
Chemical Properties
White to pale yellow powder
Uses
ivDde = 1-(4,4-Dimethyl-2,6-dioxo-cyclohexylidene)-3-methyl-butyl The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. Fmoc-Lys(Ddiv)-OH is orthogonally protected lysine. The Ddiv protection is stable to piperidine.
Uses
Fmoc-Lys(ivDde)-OH is especially useful for preparing peptides selectively modified on the Lys sidechain, such as peptides labeled peptides, PEGylated peptides or peptides cyclized through the Lys sidechain. The ivDde protective group possesses higher orthogonality regarding Boc and Fmoc in comparison to Dde. The ivDde group can be selectively removed with hydrazine in the presence of acid labile groups such as t-butyl and trityl based protecting groups.
Advantages
Fmoc-Lys(ivDde)-OH could be used to synthesize hetero-branched peptidesto avoid homodimer generation and construct heterodimers with a high ratio. This agent was used to generate Cellpenetrating peptides (CPP) and candidate peptides in one molecule[1].
References
Wen-Qu, L. I., X. U. Hong-Yan, and L. I. Zhan-Xiong. "Synthesis of End N-Ivdde Protected Amino Acid."Chinese Journal of Synthetic Chemistry 17.2(2009):213-215.
http://www.chempep.com/ChemPep_Products2_Fmoc-Amino-Acid.php?id=101224
Chen, Hui Ting, et al. "Anionic cell penetrating peptide and its use for intracellular delivery." US, US8614194. 2013.
[1] Kozaki L, et al. Disulfide linked hetero dimeric peptide arrays for screening functional peptides
inside cells. Journal of Bioscience and Bioengineering, 2019; 129: 613-618.
Fmoc-Lys(Ddiv)-OH Preparation Products And Raw materials
Raw materials
Preparation Products
Fmoc-Lys(Ddiv)-OH Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58
View Lastest Price from Fmoc-Lys(Ddiv)-OH manufacturers
- Product
- Fmoc-Lys(Ddiv)-OH 204777-78-6
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1T+
- Release date
- 2024-03-05
- Product
- FMOC-LYS(IVDDE)-OH 204777-78-6
- Price
- US $8852.00/KG
- Min. Order
- 1KG
- Purity
- 98.0%
- Supply Ability
- 1T
- Release date
- 2020-06-24
- Product
- FMOC-LYS(IVDDE)-OH 204777-78-6
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15