ChemicalBook > CAS DataBase List > 2-Chloro-3-nitropyridine

2-Chloro-3-nitropyridine

Product Name
2-Chloro-3-nitropyridine
CAS No.
5470-18-8
Chemical Name
2-Chloro-3-nitropyridine
Synonyms
AURORA KA-2997;oro-3-nitropyridine;Chloro-3-nitropyrid;2-Chloro-3-nitropyri;2-Chrolo-3-nitropyridin;2-chloro-3-nitro-pyridin;3-Nitro-2-chloropyridine;2-Chrolo-3-nitropyridine;2-CHLORO-3-NITROPYRIDINE;Pyridine, 2-chloro-3-nitro-
CBNumber
CB9206306
Molecular Formula
C5H3ClN2O2
Formula Weight
158.54
MOL File
5470-18-8.mol
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2-Chloro-3-nitropyridine Property

Melting point:
100-103 °C (lit.)
Boiling point:
260.3±20.0 °C(Predicted)
Density 
1.6616 (rough estimate)
refractive index 
1.454-1.456
Flash point:
185°C
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
Water Solubility 
Insoluble in water
pka
-2.60±0.10(Predicted)
form 
Crystalline Powder
color 
Yellow
BRN 
124482
InChI
InChI=1S/C5H3ClN2O2/c6-5-4(8(9)10)2-1-3-7-5/h1-3H
InChIKey
UUOLETYDNTVQDY-UHFFFAOYSA-N
SMILES
C1(Cl)=NC=CC=C1[N+]([O-])=O
CAS DataBase Reference
5470-18-8(CAS DataBase Reference)
NIST Chemistry Reference
2-Chloro-3-nitropyridine(5470-18-8)
EPA Substance Registry System
Pyridine, 2-chloro-3-nitro- (5470-18-8)
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Safety

Hazard Codes 
Xn,Xi
Risk Statements 
20/22-36/37/38-22
Safety Statements 
22-24/25-37/39-26-36
RIDADR 
UN 2811
WGK Germany 
3
TSCA 
T
HazardClass 
IRRITANT
PackingGroup 
Ⅲ
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
C61607
Product name
2-Chloro-3-nitropyridine
Purity
99%
Packaging
5g
Price
$42.4
Updated
2025/07/31
Sigma-Aldrich
Product number
C61607
Product name
2-Chloro-3-nitropyridine
Purity
99%
Packaging
25g
Price
$68.38
Updated
2025/07/31
TCI Chemical
Product number
C1008
Product name
2-Chloro-3-nitropyridine
Purity
>99.0%(GC)
Packaging
5g
Price
$19
Updated
2025/07/31
TCI Chemical
Product number
C1008
Product name
2-Chloro-3-nitropyridine
Purity
>99.0%(GC)
Packaging
25g
Price
$74
Updated
2025/07/31
TRC
Product number
C597058
Product name
2-Chloro-3-nitropyridine
Packaging
5g
Price
$60
Updated
2021/12/16
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2-Chloro-3-nitropyridine Chemical Properties,Usage,Production

Chemical Properties

yellow crystalline powder

Uses

2-Chloro-3-nitropyridine is often used as a pharmaceutical intermediate.

Reactions

2-Chloro-3-nitropyridine is a nucleophilic compound that reacts with amines to form substituted amines.

Synthesis

59290-85-6

5470-18-8

General procedure for the synthesis of 2-chloro-3-nitropyridine from 3-nitropyridine-2-carboxylic acid: accurately weigh 3-nitropyridine-2-carboxylic acid (50.4 mg, 0.3 mmol), sodium carbonate (64.0 mg, 0.6 mmol), sodium chloride (17.6 mg, 0.3 mmol) and tert-butyl hypochlorite (32 μL, 0.3 mmol) in a 25 mL Schlenk reaction flask. Subsequently, dichloromethane (3 mL) was added as a solvent and the reaction mixture was placed in an oil bath at 25 °C for 20 hours. After completion of the reaction, the solvent was removed by distillation under reduced pressure. The crude product was purified by silica gel column chromatography using petroleum ether/ethyl acetate as eluent to give 2-chloro-3-nitropyridine in 58% yield.

Purification Methods

It forms needles from H2O. Purify it by continuous sublimation over a period of 2 weeks at 50-60o/0.1mm [Barlin J Chem Soc 2150 1964]. The N-oxide has m 100o(from CH2Cl2/Et2O). [Taylor & Driscoll J Org Chem 25 1716 1960, Ochiai & Kaneko Chem Pharm Bull Jpn 8 28 1960, Beilstein 20/5 V 451.]

References

[1] Patent: CN108586334, 2018, A. Location in patent: Paragraph 0060-0062

2-Chloro-3-nitropyridine Preparation Products And Raw materials

Raw materials

Preparation Products

N-isopropyl-2-(piperazin-1-yl)pyridin-3-amine 4-Azaindole 1-(3-Nitorpyridin-2-yl)piperazine 2-(Piperazin-1-yl)pyridin-3-amine 3-Amino-2-[4-butoxycarbonyl(piperazino)]pyridine
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2-Chloro-3-nitropyridine Suppliers

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View Lastest Price from 2-Chloro-3-nitropyridine manufacturers

Shaanxi Dideu New Materials Co. Ltd
Product
2-Chloro-3-nitropyridine 5470-18-8
Price
US $0.00-0.00/KG
Min. Order
1KG
Purity
98.0%
Supply Ability
10000KGS
Release date
2025-05-30
WUHAN FORTUNA CHEMICAL CO., LTD
Product
2-Chloro-3-nitropyridine 5470-18-8
Price
US $0.00/Kg/Bag
Min. Order
1KG
Purity
98%min GC
Supply Ability
100KGS
Release date
2021-07-23
Henan Fengda Chemical Co., Ltd
Product
2-Chloro-3-nitropyridine 5470-18-8
Price
US $6.00-0.90/KG
Min. Order
1KG
Purity
99%
Supply Ability
g-kg-tons, free sample is available
Release date
2024-01-24

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  • Chloropyridines
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