2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Product Name: 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
CAS No.: 871839-91-7
Chemical Name: 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE
Synonyms: 2-ISOPROXYPYRIDINE-5-BORONIC ACID PINACOLATE;2-Isoproxypyridine-4-boronic acid pinacol ester;2-isopropoxypyridine -5-boronic acid pinacolate;6-Isopropoxy-3-pyridylboronic Acid Pinacol Ester;2-isopropoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(propan-2-yloxy)-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine;2-(6-Isopropoxy-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane;2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE;2-propan-2-yloxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine;Pyridine,2-(1-methylethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-
CBNumber: CB9213601
Molecular Formula: C14H22BNO3
Formula Weight: 263.14
MOL File: 871839-91-7.mol

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2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Property

Melting point:: 72-75℃
Boiling point:: 347.6±27.0 °C(Predicted)
Density: 1.03±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: powder to crystal
pka: 4.23±0.24(Predicted)
color: White to Light yellow

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Safety

HS Code: 2933399990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: I1099
Product name: 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging: 200MG
Price: $31
Updated: 2025/07/31

TCI Chemical

Product number: I1099
Product name: 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine
Packaging: 1G
Price: $104
Updated: 2025/07/31

TRC

Product number: I918138
Product name: 2-Isopropoxypyridine-5-boronicacid,pinacolester
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: I918138
Product name: 2-Isopropoxypyridine-5-boronicacid,pinacolester
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Chem-Impex

Product number: 39886
Product name: 2-Isopropoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine,98%(GC)
Purity: 98%(GC)
Packaging: 1G
Price: $98.56
Updated: 2021/12/16

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2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Chemical Properties,Usage,Production

Uses

2-Isopropoxypyridine-5-boronic acid, pinacol ester

Synthesis

870521-31-6

73183-34-3

871839-91-7

Under nitrogen protection, to a stirred 1,4-dioxane (50 ml) of 5-bromo-2-isopropoxypyridine (5 g, 23.14 mmol), potassium acetate (5.68 g, 57.9 mmol), and 4,4,4,4,5,5,5,5-octamethyl-2,2'-bis(1,3,2-dioxaborolane) (8.81 g, 34.7 mmol) PdCl2(dppf)-DCM adduct (1.89 g, 2.314 mmol) was added to the suspension. The reaction mixture was heated at 110°C for 1 hour. After completion of the reaction, water was added to the mixture and extracted with ethyl acetate. The organic layers were combined, washed sequentially with water and brine, dried with Na2SO4 and concentrated under reduced pressure. The crude product was purified by column chromatography to afford 6-isopropoxypyridine-3-boronic acid pinacol ester as an oil (5 g, 82% yield).1H NMR (400 MHz, chloroform-d) δ 8.54 (s, 1H), 7.92 (d, J = 8.3Hz, 1H), 6.76-6.46 (m, 1H), 5.45-5.25 (m, 1H), and 1.37 (d, J = 2.4Hz, 6H), 1.28 (s, 12H).

References

[1] Patent: WO2017/37682, 2017, A1. Location in patent: Page/Page column 71; 72
[2] Patent: WO2005/123675, 2005, A1. Location in patent: Page/Page column 55
[3] Patent: WO2016/161160, 2016, A1. Location in patent: Paragraph 0160
[4] ACS Medicinal Chemistry Letters, 2018, vol. 9, # 7, p. 761 - 767
[5] Patent: WO2009/105500, 2009, A1. Location in patent: Page/Page column 219-220

2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE Suppliers

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View Lastest Price from 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE manufacturers

Career Henan Chemical Co

Product: 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 871839-91-7
Price: US $1.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 200kg
Release date: 2018-12-19

871839-91-7, 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINERelated Search:

3-Pyridylboronic acid Pentaborane 2-ISOPROPOXY-3-(4,4,5,5-TETRAMETHYL-[1,3,2]DIOXABOROLAN-2-YL)-PYRIDINE 2-Methoxy-5-pyridineboronic acid 2-(Tetrahydropyran-4-yloxy)pyridine-5-boronic acid, pinacol ester 2-HYDROXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 6-HYDROXY-3-PYRIDINEBORONIC ACID (6-ETHOXYPYRIDIN-3-YL)BORONIC ACID 2-ISOPROXYPYRIDINE-5-BORONIC ACID 2-ETHOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE 2-METHOXYPYRIDINE-5-BORONIC ACID PINACOL ESTER 2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

2-ISOPROXYPYRIDINE-5-BORONIC ACID PINACOLATE

2-ISOPROPOXY-5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)PYRIDINE

Pyridine,2-(1-methylethoxy)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-

2-isopropoxypyridine -5-boronic acid pinacolate

2-Isoproxypyridine-4-boronic acid pinacol ester

2-(propan-2-yloxy)-5-(tetraMethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-propan-2-yloxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

2-(6-Isopropoxy-3-pyridyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

6-Isopropoxy-3-pyridylboronic Acid Pinacol Ester

2-isopropoxy-5-(tetramethyl-1,3,2-dioxaborolan-2-yl)pyridine

871839-91-7

Boronic Ester