Hygrolidin

Product Name: Hygrolidin
CAS No.: 83329-73-1
Chemical Name: Hygrolidin
Synonyms: 1166C;Hygrolidin;Antibiotic 1166C;2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)
CBNumber: CB92219966
Molecular Formula: C38H58O11
Formula Weight: 690.86
MOL File: 83329-73-1.mol

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Hygrolidin Property

Boiling point:: 821.1±65.0 °C(Predicted)
Density: 1.17±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
form: A solid
pka: 3.28±0.10(Predicted)

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Safety

HS Code: 29419000

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 28116
Product name: Hygrolidin
Packaging: 1mg
Price: $319
Updated: 2024/03/01

Cayman Chemical

Product number: 28116
Product name: Hygrolidin
Packaging: 5mg
Price: $1276
Updated: 2024/03/01

TRC

Product number: H997603
Product name: Hygrolidin
Packaging: 1mg
Price: $375
Updated: 2021/12/16

AK Scientific

Product number: 4622ED
Product name: (E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid
Packaging: 1mg
Price: $545
Updated: 2021/12/16

AK Scientific

Product number: 4622ED
Product name: (E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid
Packaging: 5mg
Price: $1659
Updated: 2021/12/16

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Hygrolidin Chemical Properties,Usage,Production

Description

Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC₅₀s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G₁ and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC₅₀s = 1.1, 72.5, 77, and 24.5 nM, respectively).

Uses

Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against Valsa ceratosperma, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumour cells, and inhibits the growth of solid tumour-derived cell lines such as DLD-1 human colon cancer cells with increased cells in G1 and S phases. Hygrolidin decreases cyclin-dependent kinase (cdk) 4, cyclin D and cyclin B, and increases cyclin E and p21 levels. Hygrolidin-induced p21 inhibits cyclin A-cdk2 complex more strongly than cyclin E-cdk2 complex. It also increases p21 mRNA in DLD-1 cells, but not in normal fibroblasts.

Uses

Hygrolidin is a tumor growth and cdk inhibitor.

IC 50

Macrolide

References

[1] HARUO SETO ?. The structure of a new antibiotic, hygrolidin[J]. Tetrahedron Letters, 1982, 23 26: Pages 2667-2670. DOI: 10.1016/s0040-4039(00)87426-2
[2] MANABU KAWADA . Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases[J]. Biochemical and biophysical research communications, 2002, 298 1: Pages 178-183. DOI: 10.1016/s0006-291x(02)02416-6
[3] F. ANNANG . High-Throughput Screening Platform for Natural Product–Based Drug Discovery Against 3 Neglected Tropical Diseases: Human African Trypanosomiasis, Leishmaniasis, and Chagas Disease[J]. SLAS Discovery, 2015, 20 1: Pages 82-91. DOI: 10.1177/1087057114555846

Hygrolidin Preparation Products And Raw materials

Raw materials

Preparation Products

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Hygrolidin Suppliers

China 22 India 1 United Kingdom 2 United States 5 Global 30

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
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Lynnchem

Tel: 86-(0)29-85992781 17792393971
Email: info@lynnchem.com
Country: China
ProdList: 4587
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Novachemistry

Tel: 44-20819178-90 02081917890
Fax: (0)2080432064
Email: info@novachemistry.com
Country: United Kingdom
ProdList: 4381
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Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
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Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 +86-13028896684;
Email: sales@rrkchem.com
Country: China
ProdList: 57422
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BOC Sciences

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Email: inquiry@bocsci.com
Country: United States
ProdList: 19654
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
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Meng Cheng Technology (Shanghai) Co., LTD

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Country: China
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Zhejiang Huida Biotech Co., LTD

Tel: 0571-89903882 18679456698
Email: mingxinzhu@huidabiotech.com
Country: China
ProdList: 2975
Advantage: 58

83329-73-1, HygrolidinRelated Search:

1166C

Antibiotic 1166C

Hygrolidin

2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)

83329-73-1

Antibiotic