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Hygrolidin

Product Name
Hygrolidin
CAS No.
83329-73-1
Chemical Name
Hygrolidin
Synonyms
1166C;Hygrolidin;Antibiotic 1166C;2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)
CBNumber
CB92219966
Molecular Formula
C38H58O11
Formula Weight
690.86
MOL File
83329-73-1.mol
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Hygrolidin Property

Boiling point:
821.1±65.0 °C(Predicted)
Density 
1.17±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
Soluble in DMSO
form 
A solid
pka
3.28±0.10(Predicted)
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Safety

HS Code 
29419000
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
28116
Product name
Hygrolidin
Packaging
1mg
Price
$319
Updated
2024/03/01
Cayman Chemical
Product number
28116
Product name
Hygrolidin
Packaging
5mg
Price
$1276
Updated
2024/03/01
TRC
Product number
H997603
Product name
Hygrolidin
Packaging
1mg
Price
$375
Updated
2021/12/16
AK Scientific
Product number
4622ED
Product name
(E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid
Packaging
1mg
Price
$545
Updated
2021/12/16
AK Scientific
Product number
4622ED
Product name
(E)-4-[6-Ethyl-2-hydroxy-2-[3-hydroxy-4-[(4Z,6Z,12Z,14Z)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxo-1-oxacyclohexadeca-4,6,12,14-tetraen-2-yl]pentan-2-yl]-5-methyloxan-4-yl]oxy-4-oxobut-2-enoicacid
Packaging
5mg
Price
$1659
Updated
2021/12/16
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Hygrolidin Chemical Properties,Usage,Production

Description

Hygrolidin is a macrocyclic lactone originally isolated from S. hygroscopicus. It inhibits proliferation of a variety of cancer cell lines, including DLD-1 colon cancer, LNCaP prostate cancer, and K562 leukemia cells (IC50s = 2.9, 5.2, and 33 ng/ml, respectively). Hygrolidin induces the expression and levels of p21 in DLD-1 cells, but not WI-38 fibroblasts, and leads to cell accumulation in the G1 and S phases without inducing apoptosis. It has antiparasitic activity against T. cruzi, L. donovani, and T. b. brucei but also induces cytotoxicity in HepG2 cells (IC50s = 1.1, 72.5, 77, and 24.5 nM, respectively).

Uses

Hygrolidin is a 16-membered macrocyclic lactone closely related to the bafilomycins, active against Valsa ceratosperma, the pathogen of apple canker disease. Hygrolidin is active against SV40 tumour cells, and inhibits the growth of solid tumour-derived cell lines such as DLD-1 human colon cancer cells with increased cells in G1 and S phases. Hygrolidin decreases cyclin-dependent kinase (cdk) 4, cyclin D and cyclin B, and increases cyclin E and p21 levels. Hygrolidin-induced p21 inhibits cyclin A-cdk2 complex more strongly than cyclin E-cdk2 complex. It also increases p21 mRNA in DLD-1 cells, but not in normal fibroblasts.

Uses

Hygrolidin is a tumor growth and cdk inhibitor.

IC 50

Macrolide

References

[1] HARUO SETO ?. The structure of a new antibiotic, hygrolidin[J]. Tetrahedron Letters, 1982, 23 26: Pages 2667-2670. DOI: 10.1016/s0040-4039(00)87426-2
[2] MANABU KAWADA . Hygrolidin induces p21 expression and abrogates cell cycle progression at G1 and S phases[J]. Biochemical and biophysical research communications, 2002, 298 1: Pages 178-183. DOI: 10.1016/s0006-291x(02)02416-6
[3] F. ANNANG . High-Throughput Screening Platform for Natural Product–Based Drug Discovery Against 3 Neglected Tropical Diseases: Human African Trypanosomiasis, Leishmaniasis, and Chagas Disease[J]. SLAS Discovery, 2015, 20 1: Pages 82-91. DOI: 10.1177/1087057114555846

Hygrolidin Preparation Products And Raw materials

Raw materials

Preparation Products

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Hygrolidin Suppliers

China 22 India 1 United Kingdom 2 United States 5 Global 30
Novachemistry
Tel
44-20819178-90 02081917890
Fax
(0)2080432064
Email
info@novachemistry.com
Country
United Kingdom
ProdList
4381
Advantage
58
Apollo Scientific Ltd.
Tel
--
Fax
--
Email
sales@apolloscientific.co.uk
Country
United Kingdom
ProdList
6084
Advantage
88

83329-73-1, HygrolidinRelated Search:


  • 1166C
  • Antibiotic 1166C
  • Hygrolidin
  • 2-Butenedioic acid (2E)-, mono[(2R,4R,5S,6R)-6-ethyltetrahydro-2-hydroxy-2-[(1S,2R,3S)-2-hydroxy-3-[(2R,3S,4E,6E,9S,10S,11R,12E,14E)-10-hydroxy-3-methoxy-7,9,11,13,15-pentamethyl-16-oxooxacyclohexadeca-4,6,12,14-tetraen-2-yl]-1-methylbutyl]-5-methyl-2H-pyran-4-yl] ester (9CI)
  • 83329-73-1
  • Antibiotic