DONITRIPTAN

Product Name: DONITRIPTAN
CAS No.: 170912-52-4
Chemical Name: DONITRIPTAN
Synonyms: DONITRIPTAN;DONITRIPTANUM;Donitriptan hydrochloride;Donitriptan, 10 mM in DMSO;4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile;Benzonitrile, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-;1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazinehydrochloride;5-hydroxytryptamine Receptor,Donitriptan,Serotonin Receptor,Inhibitor,inhibit,5-HT Receptor
CBNumber: CB92451001
Molecular Formula: C23H25N5O2
Formula Weight: 403.48
MOL File: 170912-52-4.mol

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DONITRIPTAN Property

Boiling point:: 727.1±60.0 °C(Predicted)
Density: 1.32±0.1 g/cm3(Predicted)
storage temp.: Desiccate at RT
solubility: Soluble in DMSO
pka: 16.72±0.30(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Usbiological

Product number: 255184
Product name: Donitriptan hydrochloride
Packaging: 10mg
Price: $409
Updated: 2021/12/16

ChemScene

Product number: CS-0025002
Product name: Donitriptan
Packaging: 25mg
Price: $550
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000403
Product name: DONITRIPTAN
Purity: 95.00%
Packaging: 10MG
Price: $721.59
Updated: 2021/12/16

ChemScene

Product number: CS-0025002
Product name: Donitriptan
Packaging: 50mg
Price: $900
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: INB0000403
Product name: DONITRIPTAN
Purity: 95.00%
Packaging: 50MG
Price: $1327.97
Updated: 2021/12/16

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DONITRIPTAN Chemical Properties,Usage,Production

Uses

A novel 5-hydroxytryptamine (5-HT) derivative with potent, selective, and unique high intrinsic activity at 5-HT1B/1D receptors in models relevant to migraine. An antimigraine agent.

Biological Activity

Brain penetrant 5-HT 1B/1D agonist (pK i values are 9.3 and 9.4 for 5-HT 1D and 5-HT 1B respectively). Inhibits capsaicin-induced external carotid vasodilation and produces selective carotid vasoconstriction in various animal species. Displays antimigraine activity.

IC 50

5-HT_1B Receptor: 9.4 (pKi); 5-HT_1D Receptor: 9.3 (pKi)

DONITRIPTAN Preparation Products And Raw materials

Raw materials

Preparation Products

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DONITRIPTAN Suppliers

China 24 United Kingdom 1 United States 3 Global 28

3B Pharmachem (Wuhan) International Co.,Ltd.

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Proteintech China

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170912-52-4, DONITRIPTANRelated Search:

DONITRIPTAN

1-[[[3-(2-Aminoethyl)-1H-indol-5-yl]oxy]acetyl]-4-(4-cyanophenyl)-piperazinehydrochloride

Donitriptan hydrochloride

DONITRIPTANUM

4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]piperazin-1-yl]benzonitrile

Benzonitrile, 4-[4-[2-[[3-(2-aminoethyl)-1H-indol-5-yl]oxy]acetyl]-1-piperazinyl]-

5-hydroxytryptamine Receptor,Donitriptan,Serotonin Receptor,Inhibitor,inhibit,5-HT Receptor

Donitriptan, 10 mM in DMSO

170912-52-4