2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
- Product Name
- 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
- CAS No.
- 265312-55-8
- Chemical Name
- 2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE
- Synonyms
- RYUVIDINE;Cdk4 Inhibitor III;2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione;2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE;2-methyl-5-[(4-methylphenyl)amino]benzothiazole-4,7-dione;4,7-Benzothiazoledione, 2-methyl-5-[(4-methylphenyl)amino]-
- CBNumber
- CB92453429
- Molecular Formula
- C15H12N2O2S
- Formula Weight
- 284.33
- MOL File
- 265312-55-8.mol
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Property
- Boiling point:
- 463.8±45.0 °C(Predicted)
- Density
- 1.416±0.06 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- Soluble to 20 mM in DMSO and to 5 mM in ethanol
- form
- Black-purple solid
- pka
- -1.63±0.20(Predicted)
- color
- Brown to black
N-Bromosuccinimide Price
- Product number
- 219478
- Product name
- Cdk4 Inhibitor III - CAS 265312-55-8 - Calbiochem
- Packaging
- 5mg
- Price
- $245
- Updated
- 2024/03/01
- Product number
- 16614
- Product name
- Ryuvidine
- Purity
- ≥95%
- Packaging
- 1mg
- Price
- $33
- Updated
- 2024/03/01
- Product number
- 16614
- Product name
- Ryuvidine
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $96
- Updated
- 2024/03/01
- Product number
- 16614
- Product name
- Ryuvidine
- Purity
- ≥95%
- Packaging
- 10mg
- Price
- $160
- Updated
- 2024/03/01
- Product number
- 16614
- Product name
- Ryuvidine
- Purity
- ≥95%
- Packaging
- 25mg
- Price
- $317
- Updated
- 2024/03/01
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Chemical Properties,Usage,Production
Uses
Ryuvidine is an antifungal agent used against pathogenic fungi.
Definition
ChEBI: 2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione is an aminotoluene.
General Description
A cell-permeable dioxobenzothiazole compound that acts a selective Cdk4 inhibitor (IC50 = 6.0 μM for Cdk4/D1 and >200 μM for Cdk2/A). Exhibit better cytotoxic potential against cancer cells (IC50 = 0.61, 1.08, 0.30, and 1.21 μg/ml against A 549, Col 1, HL-60, and HepG2 tumor cells, respectively) than Cisplatin (Cat. No. 232120).
Biological Activity
Cyclin-dependent kinase (cdk) 4 inhibitor (IC 50 = 6.0 μ M at cdk4/cyclin D1) that displays > 33-fold selectivity over cdk2 (IC 50 > 200 μ M at cdk2/cyclin A). Cytotoxic against a range of human cancer cells (IC 50 values are 0.30, 0.61, 1.08 and 1.21 μ g/mL for HL-60, A549, Col 1 and HepG2 cells respectively).
Biochem/physiol Actions
Cell permeable: yes
storage
Store at +4°C
2-METHYL-5-[(4-METHYLPHENYL)AMINO]-4,7-BENZOTHIAZOLEDIONE Preparation Products And Raw materials
Raw materials
Preparation Products
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