2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID
- Product Name
- 2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID
- CAS No.
- 952681-82-2
- Chemical Name
- 2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID
- Synonyms
- Reaxys ID: 15583751;spiro[chroman-2,4'-piperidine]-4-yl);2-(1'-tert-butoxycarbonylspiro[chromane-2,4'-piperidine]-4-yl)acetic acid;2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid;2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid;2-[1'-[(2-Methylpropan-2-yl)oxycarbonyl]spiro[3,4-dihydrochromene-2,4'-piperidine]-4-yl]acetic acid;Spiro[2H-1-benzopyran-2,4'-piperidine]-4-acetic acid, 1'-[(1,1-diMethylethoxy)carbonyl]-3,4-dihydro-
- CBNumber
- CB92468821
- Molecular Formula
- C20H27NO5
- Formula Weight
- 361.43
- MOL File
- 952681-82-2.mol
2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Property
- Boiling point:
- 516.4±50.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.54±0.10(Predicted)
N-Bromosuccinimide Price
- Product number
- 074548
- Product name
- 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $693
- Updated
- 2021/12/16
- Product number
- W9732
- Product name
- 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)aceticacid
- Packaging
- 1g
- Price
- $709
- Updated
- 2021/12/16
- Product number
- 074548
- Product name
- 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)acetic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $1498
- Updated
- 2021/12/16
- Product number
- CHM0125163
- Product name
- 2-(1'-(TERT-BUTOXYCARBONYL)SPIRO(CHROMAN-2,4'-PIPERIDINE)-4-YL)ACETIC ACID
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $1566.18
- Updated
- 2021/12/16
- Product number
- W9732
- Product name
- 2-(1'-(tert-Butoxycarbonyl)spiro[chroman-2,4'-piperidine]-4-yl)aceticacid
- Packaging
- 100mg
- Price
- $215
- Updated
- 2021/12/16
2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Chemical Properties,Usage,Production
Synthesis
952681-81-1
952681-82-2
Preparation of 5.7: Tert-butyl 4-(2-ethoxy-2-oxoethyl)spiro[chromane-2,4'-piperidine]-1'-carboxylate (5.6, 2.0 g, 5.1 mmol) was dissolved in a solvent mixture of methanol (30 mL), tetrahydrofuran (30 mL) and water (30 mL). To this solution was added lithium hydroxide monohydrate (1.35 g, 32 mmol). The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated under vacuum to remove the organic solvent. The aqueous phase was washed with ether to remove non-polar impurities. Subsequently, the aqueous layer was acidified with 1N HCl to pH about 4 and extracted with dichloromethane. The organic extracts were combined, dried over anhydrous sodium sulfate, filtered and concentrated in vacuum to afford the target product 2-(1'-(tert-butoxycarbonyl)spiro[chroman-2,4'-piperidin]-4-yl)acetic acid (5.7). Yield: 100%. 1H NMR (400 MHz, DMSO-d6) δ: 7.26 (m, 1H), 7.10 (m, 1H), 6.86 (m, 1H), 6.90 (m, 1H), 3.75 (m, 1H), 3.63 (m, 1H), 3.22 (m, 2H), 2.93 (m, 2H), 2.32 (dd, 1H) , 2.0 (m, 1H), 2.68-2.52 (m, 4H), 1.40 (s + m, 10H).
References
[1] Patent: WO2007/118151, 2007, A2. Location in patent: Page/Page column 60; 89; 90
2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-(1'-(TERT-BUTOXYCARBONYL)SPIRO[CHROMAN-2,4'-PIPERIDINE]-4-YL)ACETIC ACID Suppliers
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