N-(4-Cyanophenyl)guanidine

Product Name: N-(4-Cyanophenyl)guanidine
CAS No.: 5637-42-3
Chemical Name: N-(4-Cyanophenyl)guanidine
Synonyms: Etravirine Impurity 14;4-Guanidinobenzonitrile;4-Cyanophenyl Guanidine;N-(4-Cyanophenyl)guanidine;1-(4-cyanophenyl)guanidine;Guanidine, N-(4-cyanophenyl)-;N-(4-Cyanophenyl)guanidine,97%
CBNumber: CB92484667
Molecular Formula: C8H8N4
Formula Weight: 160.18
MOL File: 5637-42-3.mol

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N-(4-Cyanophenyl)guanidine Property

Melting point:: 155-162°C
Boiling point:: 316.6±44.0 °C(Predicted)
Density: 1.25±0.1 g/cm3(Predicted)
vapor pressure: 0-0Pa at 20-25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO, Methanol
form: Solid
pka: 9.91±0.10(Predicted)
color: Off-White
InChI: InChI=1S/C8H8N4/c9-5-6-1-3-7(4-2-6)12-8(10)11/h1-4H,(H4,10,11,12)
InChIKey: BTDGLZSKNFJBER-UHFFFAOYSA-N
SMILES: N(C1=CC=C(C#N)C=C1)C(=N)N
LogP: -2.2-0.4 at 20℃ and pH7.1-11

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Safety

HS Code: 2926.90.4801

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: C3387
Product name: 1-(4-Cyanophenyl)guanidine
Purity: >99.0%(HPLC)(N)
Packaging: 1g
Price: $27
Updated: 2025/07/31

TCI Chemical

Product number: C3387
Product name: 1-(4-Cyanophenyl)guanidine
Purity: >99.0%(HPLC)(N)
Packaging: 5g
Price: $57
Updated: 2025/07/31

TRC

Product number: C982120
Product name: N-(4-Cyanophenyl)guanidine
Packaging: 1g
Price: $135
Updated: 2021/12/16

TRC

Product number: C982120
Product name: N-(4-Cyanophenyl)guanidine
Packaging: 500mg
Price: $85
Updated: 2021/12/16

TRC

Product number: C982120
Product name: N-(4-Cyanophenyl)guanidine
Packaging: 5g
Price: $545
Updated: 2021/12/16

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N-(4-Cyanophenyl)guanidine Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

An intermediate in the preparation of Etravirine

Synthesis

420-04-2

873-74-5

5637-42-3

The general procedure for the synthesis of N-(4-cyanophenyl)guanidine from cyanamide and p-aminobenzonitrile is as follows: P-aminobenzonitrile (100 g), ethanol (500 ml), concentrated nitric acid (36 ml), and a 50% aqueous ammoniacal nitrile solution (54 ml) were mixed and heated to reflux. The reflux reaction was maintained for 16 hours. Upon completion of the reaction, the reaction mixture was cooled to 0 °C, followed by the slow addition of methyl tert-butyl ether (500 mL) at 0 to 5 °C. The mixture was continued to be stirred at 0 to 5 °C for 5 h. The precipitated solid was separated by filtration to give 59 g of guanidine nitrate. Guanidine nitrate (59 g) was dissolved in water (590 mL) and 1M sodium hydroxide solution (325 mL) was added. The precipitated solid was separated by filtration again and dried to give 33 g of 1-(4-cyanophenyl)guanidine.

References

[1] European Journal of Medicinal Chemistry, 2010, vol. 45, # 1, p. 244 - 255
[2] Patent: WO2012/1695, 2012, A1. Location in patent: Page/Page column 10
[3] Patent: US2013/96148, 2013, A1. Location in patent: Paragraph 0085; 0086
[4] Patent: US2015/336900, 2015, A1. Location in patent: Paragraph 0027; 0028

N-(4-Cyanophenyl)guanidine Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(4-Cyanophenyl)guanidine Suppliers

Americas 1 Canada 1 China 89 Europe 1 India 3 Japan 1 United Kingdom 1 United States 10 Global 107

TCI Chemicals (India) Pvt. Ltd.

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Email: sales-in@tcichemicals.com
Country: India
ProdList: 6768
Advantage: 58

SynZeal Research Pvt Ltd

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Email: standards@synzeal.com
Country: India
ProdList: 6514
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A.J Chemicals

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Email: sales@ajchem.in
Country: India
ProdList: 6100
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View Lastest Price from N-(4-Cyanophenyl)guanidine manufacturers

Henan Fengda Chemical Co., Ltd

Product: N-(4-Cyanophenyl)guanidine 5637-42-3
Price: US $5.00-0.10/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-16

Career Henan Chemical Co

Product: 1-(4-Cyanophenyl)guanidine 5637-42-3
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 100KG
Release date: 2018-12-25

5637-42-3, N-(4-Cyanophenyl)guanidineRelated Search:

N-(4-Cyanophenyl)guanidine

4-Cyanophenyl Guanidine

4-Guanidinobenzonitrile

1-(4-cyanophenyl)guanidine

Guanidine, N-(4-cyanophenyl)-

N-(4-Cyanophenyl)guanidine,97%

Etravirine Impurity 14

5637-42-3

Intermediate of Etravirine

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals