ChemicalBook > CAS DataBase List > VU 0357017 hydrochloride

VU 0357017 hydrochloride

Product Name
VU 0357017 hydrochloride
CAS No.
1135242-13-5
Chemical Name
VU 0357017 hydrochloride
Synonyms
CS-2319;VU0357017;CID 25010775;SID 56353039;VU0357017 HCI;ML071 hydrochloride;VU 0357017 hydrochloride;VU0357017 monohydrochloride;Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride;VU0-357017;VU 0357017;CID-25010775; VU-0357017 HYDROCHLORIDE; VU 0357017 HYDROCHLORIDE
CBNumber
CB92546794
Molecular Formula
C18H28ClN3O3
Formula Weight
369.9
MOL File
1135242-13-5.mol
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VU 0357017 hydrochloride Property

storage temp. 
Inert atmosphere,2-8°C
solubility 
DMSO: ≥10mg/mL
form 
powder
color 
white to off-white
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Safety

Hazard Codes 
N
Risk Statements 
52/53
Safety Statements 
61
WGK Germany 
2
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
V4640
Product name
VU0357017 monohydrochloride
Purity
≥98% (HPLC)
Packaging
5mg
Price
$134
Updated
2024/03/01
Sigma-Aldrich
Product number
V4640
Product name
VU0357017 monohydrochloride
Purity
≥98% (HPLC)
Packaging
25mg
Price
$465
Updated
2022/05/15
Cayman Chemical
Product number
11939
Product name
VU0357017 (hydrochloride)
Purity
≥98%
Packaging
1mg
Price
$33
Updated
2024/03/01
Cayman Chemical
Product number
11939
Product name
VU0357017 (hydrochloride)
Purity
≥98%
Packaging
5mg
Price
$90
Updated
2024/03/01
Cayman Chemical
Product number
11939
Product name
VU0357017 (hydrochloride)
Purity
≥98%
Packaging
10mg
Price
$164
Updated
2024/03/01
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VU 0357017 hydrochloride Chemical Properties,Usage,Production

Uses

VU0357017 is a subtype-selective M1 muscarinic acetylcholine allosteric agonist. VU0357017 has a potency of 200 nM and Achmax of 81% and had no activity at M2-M5 up to the highest concentrations tested and also had little or no detectable antagonist activity at any other mAChR subtype at concentrations over 2 orders of magnitude higher than those required to activate M1 or activity at a large panel of GPCRs, ion channels, and transporters. In contrast, TBPB inhibited responses to ACh at each of the other mAChR subtypes. VU0357017 was active in reversing cognitive deficits induced by Scopolamine (S200000) in a preclinical rodent model.

Uses

VU 0357017 Hydrochloride is a cholinergic M1 receptor antagonist and a cholinomimetic agent used for the treatment of behavioral and/or mental disorders.

storage

+4°C

VU 0357017 hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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VU 0357017 hydrochloride Suppliers

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1135242-13-5, VU 0357017 hydrochlorideRelated Search:

N-[3-Oxo-3-[4-(4-pyridinyl)-1-piperazinyl]propyl]-2,1,3-benzothiadiazole-4-sulfonamide VU 0285683 VU0155041 VU0134992(hydrochloride) VU6005649 VU 591 hydrochloride VU0810464 VU0483605 N-(4-Chloro-3-methoxyphenyl)-2-pyridinecarboxamide 1-(4-Methoxybenzyl)-5-trifluoromethoxyisatin VU 6008667 (1R,2R)-N-([S]-1-{4-[5-broMo-2-oxo-2,3-dihydro-1H-benzo(d)iMidazol-1-yl]piperidin-1-yl}propan-2-yl)-2-phenylcyclopropanecarboxaMide 5-Amino-3,4-dimethyl-thieno[2,3-c]pyridazine-6-carboxylic acid 4-trifluoromethanesulfonyl-benzylamide 3-methylsulfanyl-7,8-dihydro-6H-cyclopenta[4,5]thieno[1,2-c]pyrimidin-1-amine VU 0360172 VU 0365114 VU 0357121 VU 0360223

  • VU 0357017 hydrochloride
  • VU0-357017;VU 0357017;CID-25010775; VU-0357017 HYDROCHLORIDE; VU 0357017 HYDROCHLORIDE
  • CS-2319
  • 4-[[2-[(2-Methylbenzoyl)aMino]ethyl]aMino]-1-piperidinecarboxylic Acid Ethyl Ester Hydrochloride
  • 4-[[2-[(2-Methylbenzoyl)amino]ethyl]amino]-1-piperidinecarboxylic acid ethyl ester monohydrochloride
  • CID 25010775
  • Ethyl 4-(2-(2-methylbenzamido)ethylamino)piperidine-1-carboxylate hydrochloride
  • ML071 hydrochloride
  • SID 56353039
  • VU0357017 monohydrochloride
  • VU0357017
  • VU0357017 HCI
  • Muscarinic acetylcholine receptor,CID 25010775,VU 0357017,muscarinic,Inhibitor,inhibit,VU-0357017 hydrochloride,VU0357017 hydrochloride,VU0357017,mAChR,VU-0357017,CID25010775,acetylcholine,Alzheimer’s,schizophrenia
  • 1135242-13-5
  • C18H27N3O3HCl
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Pharmaceuticals
  • Positive allosteric modulator of muscarinic M1 receptors.
  • Amines