GRANISETRON IMPURITY B

Product Name: GRANISETRON IMPURITY B
CAS No.: 76272-56-5
Chemical Name: GRANISETRON IMPURITY B
Synonyms: EMANA;Granisetron EP impurity E;Granisetron EP Impurity E HCl;Endo-3-Amine-9-Methyl-Azabicyc;Granisetron IMpurity E (free base);Granisetron USP Related Compound E;Granisetron Hydrochloride Impurity E;Granisetron EP Impurity E Acetic acid;9-Methyl-9-azabicyclo[3.3.1]nonylamine;Granisetron Hydrochloride EP Impurity E
CBNumber: CB9254802
Molecular Formula: C9H18N2
Formula Weight: 154.26
MOL File: 76272-56-5.mol

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GRANISETRON IMPURITY B Property

Boiling point:: 115-119°C (18 mmHg)
Density: 0.968±0.06 g/cm3(Predicted)
storage temp.: Keep in dark place,Inert atmosphere,2-8°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Oil
pka: 11.09±0.40(Predicted)
color: Colourless to Dark Yellow
Stability:: Hygroscopic
InChI: InChI=1/C9H18N2/c1-11-8-3-2-4-9(11)6-7(10)5-8/h7-9H,2-6,10H2,1H3/t7-,8+,9-
InChIKey: HTZWHTQVHWHSHN-AYMMMOKONA-N
SMILES: CN1[C@H]2CCC[C@@H]1C[C@H](N)C2 |&1:2,6,8,r|
CAS DataBase Reference: 76272-56-5(CAS DataBase Reference)

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Safety

HS Code: 2921490090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: Y0000395
Product name: Granisetron impurity E
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: 15 mg
Price: $201
Updated: 2025/07/31

Sigma-Aldrich

Product number: Y0000395
Product name: Granisetron impurity E
Purity: European Pharmacopoeia (EP) Reference Standard
Packaging: Y0000395
Price: $197
Updated: 2024/03/01

TRC

Product number: M288600
Product name: endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine
Packaging: 50mg
Price: $55
Updated: 2021/12/16

Matrix Scientific

Product number: 074391
Product name: Endo-3-Amine-9-methyl-9-azabicyclo[3,3,1]nonane
Purity: 95+%
Packaging: 1g
Price: $22
Updated: 2021/12/16

AK Scientific

Product number: K306
Product name: Endo-3-amino-9-methyl-9-azabicyclo[3.3.1]nonane
Packaging: 1g
Price: $22
Updated: 2021/12/16

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GRANISETRON IMPURITY B Chemical Properties,Usage,Production

Chemical Properties

Pale Yellow Oil

Uses

Granisetron impurity E. An intermediate of Granisetron.

Synthesis

6164-67-6

76272-41-8

9-Methyl-9-azabicyclo[3,3,1]nonan-3-one oxime (10 g, 0.06 mol) was used as a raw material and dissolved in methanol (70 mL) and 0.88 ammonia. The hydrogenation reaction was carried out at 50 °C and 50 psi (344.8 kPa) hydrogen pressure for 16 h using 5% rhodium/carbon catalyst (1 g dry weight). Upon completion of the reaction, the mixture was cooled to room temperature and the catalyst was removed by filtration. The catalyst bed was washed with methanol and the methanol solution was subsequently evaporated under reduced pressure to afford endo-3-amino-9-methyl-9-azabicyclo[3,3,1]nonane as an oil (8.6 g, 93% yield), which solidified to a waxy solid (8.6 g, 93%) upon standing. EI analysis by GC/MS (JEOL DX303) showed the molecular ion peak m/z 154 (M+).

References

[1] Patent: US5856489, 1999, A

GRANISETRON IMPURITY B Preparation Products And Raw materials

Raw materials

Preparation Products

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GRANISETRON IMPURITY B Suppliers

Canada 1 China 217 Europe 2 Germany 2 India 12 United Kingdom 5 United States 29 Global 268

Beijing Xinze Pharmaceutical Technology Co., Ltd.

Tel: 010-61393740 13121768631
Email: weihong_1979@163.com
Country: China
ProdList: 51
Advantage: 58

Suizhou Jiake Biological Engineering Co., Ltd.

Tel: 0722-3632989 18008664499
Fax: 0722-3255139
Email: 2286801987@qq.com
Country: China
ProdList: 103
Advantage: 58

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Energy Chemical

Tel: 021-021-58432009 400-005-6266
Fax: 021-58436166
Email: sales8178@energy-chemical.com
Country: China
ProdList: 44801
Advantage: 61

Wuhan Chemwish Technology Co., Ltd

Tel: 86-027-67849912
Fax: 86-027-87531808
Email: sales@chemwish.com
Country: China
ProdList: 35896
Advantage: 56

JinYan Chemicals(ShangHai) Co.,Ltd.

Tel: 13817811078
Fax: 86-021-50426522,50426273
Email: sales@jingyan-chemical.com
Country: China
ProdList: 9976
Advantage: 60

Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
Fax: 021-64823266
Email: chenyj@titansci.com
Country: China
ProdList: 14101
Advantage: 59

Chemsky（shanghai）International Co.,Ltd.

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 32321
Advantage: 50

XiaoGan ShenYuan ChemPharm co,ltd

Tel: 15527768836
Email: 1791901229@qq.com
Country: China
ProdList: 6950
Advantage: 52

Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
Country: China
ProdList: 11705
Advantage: 57

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View Lastest Price from GRANISETRON IMPURITY B manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD

Product: GRANISETRON IMPURITY B 76272-56-5
Price: US $0.00/Kg/Bag
Min. Order: 1KG
Purity: 98%min GC
Supply Ability: 10KGS
Release date: 2021-07-21

Career Henan Chemical Co

Product: Endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane 76272-56-5
Price: US $7.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100KG
Release date: 2018-12-17

76272-56-5, GRANISETRON IMPURITY BRelated Search:

N,N-Dimethyl-1,4-phenylenediamine Kresoxim-methyl Basic Violet 1 METSULFURON METHYL Octamethylcyclotetrasilazane N-NONANE N-Methyl-2-pyrrolidone Hexamethyldisilazane Methylparaben Amantadine Methyl acrylate Methyl salicylate Methanol Tolyltriazole Lithium bis(trimethylsilyl)amide Sodium bis(trimethylsilyl)amide Tribenuron methyl Tris(hydroxymethyl)aminomethane

Granisetron IMpurity E (free base)

(1R)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-aMine

endo-3-AMino-9-Methyl-9-azabicyclo[3,3,1]nonane(endo/exo ca 5/1)

Endo-3-aMin-9-Methyl-9-azabicyclo[3,3,1] nonane

(3-endo)-9-Methyl-9-Azabicyclo[3.3.1]nonan-3-aMine

Endo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane Endo-9-methyl-9-azabicyclo[3,3,1]nonan-3-amine

(1R,3r,5S)-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine

<i>endo</i>-3-Amino-9-methyl-9-azabicyclo[3,3,1]nonane(endo/exo ca 5/1)

ndo-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane

Granisetron EP impurity E

endo‐1‐Amino‐9‐methyl‐9‐azabicyclo[3.3.1]nonane

9-methyl-9-azabicyclo[3.3.1]nonan-5-amine

ENDO-3-AMINE-9-METHYL-9-AZABICYCLO[3,3,1]NONAN

ENDO-3-AMINE-9-METHYL-9-AZABICYCLO[3,3,1]NONANE

ENDO-3-AMINE-9-METHYL-AZABICYCLO[3.3.1] NONANE

ENDO-3-AMINO-9-METHYL-9-AZABICYCLO[3.3.1]NONANE

ENDO-9-METHYL-9-AZA-BICYCLO[3.3.1]NON-3-YLAMINE

ENDO-9-METHYL-9-AZABICYCLO3,3,1-NONAN-3-AMINE

ENDO-9-METHYL-9-AZABICYCLO[3,3,1] NONANE-3-AMINE

EMANA

Endo-9-Methyl-9-Azabicyclo-3,3,1-Nonan-3-Amine(ForGranisetronHcl)

b-3-Amino-9-methyl-9-azabicyclo(3.3.1)-nonane, Granisetron Impurity E (free base)

Endo-3-Amine-9-Methyl-Azabicyc

Endo-9-methyl-9-azabicyclo[3,3,1] nonan-3-amine 76272-56-5

ENDO-9-METHYL-9-AZABICYCLO[3,3,1]-NONAN-3- AMINE / EMANA

9-Methyl-9-azabicyclo[3.3.1]nonylamine

1-AMINO-9-METHYL-9-AZABICYCLO[3,3,1]-NONANE

9-METHYL-9-AZA-BICYCLO[3,3,1]NON-3-YL-AMINE

endo-9-Methyl-9-azabicyclo[3.3.1]-3-nonylamine

EMANA(Endo-9-methyl-9-azabicyclo[3,3,1]-nonan-3-amine)

do-3-amine-9-methyl-9-azabicyclo[3,3,1]nonane

endo-9-Methyl-9-azabicyclo[3.3.1]nonan-3-amine (Granisetron Impurity E)

9-Azabicyclo[3.3.1]nonan-3-amine, 9-methyl-, (3-endo)-

Endo-9-Methy -9-Azabicyclo[3,31]Nonan-3-Amine

-3-Amino-9-methyl-9-azabicyclo(3.3.1)-nonane, Granisetron Impurity E (free base)

Granisetron EP Impurity E Acetic acid

Granisetron EP Impurity E HCl

ENDO-9-METHYL-9-AZABICYCLO [3,3,1]-NONAN-3-AMIN

Granisetron USP Related Compound E

Granisetron Hydrochloride Impurity E

Endo-9-methyl-9-azabicycolo [3.3.1] nonan-3-amine

Granisetron Hydrochloride EP Impurity E

Introverted 3-amino-9-methyl-9-azabicyclic [3,3,1] nonane

9-Methyl-9-Azabicyclo[3,3,1]Nonane-3Amine

rel-(1R,3r,5S)-9-methyl-9-azabicyclo[3.3.1]nonan-3-amine

76272-56-5

Amines

Chiral Reagents

Impurities

Intermediates & Fine Chemicals

(intermediate of granisetron)

Amines and Anilines

Heterocycles

Pharmaceuticals